sisomicin sulphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sisomicin sulphate
• 英文别名: sisomicin sulfate；(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
• 化学式: C₁₉H₃₇N₅O₇*H₂O₄S
• 分子量: 545.612
• InChiKey: JVTNJDPXUPRGIE-ZQTXFFGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  297
• 氢给体数：
  10
• 氢受体数：
  16

文献信息

• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。
• Phenyl derivative
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US10117861B2

  公开（公告）日：2018-11-06

  The compound of the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P2-mediated diseases such as diseases resulting from vascular constriction, fibrosis, and respiratory diseases.

  式 (I-1) 的化合物： 其中所有符号的含义与说明书中所述的相同，具有两个环状基团，特别是特定取代位置上的苯氧基，因此具有较高的人体 S1P2 拮抗活性。因此，该化合物可用作 S1P2 介导的疾病（如血管收缩、纤维化和呼吸系统疾病引起的疾病）的治疗剂。
• Antibiotic coating of implants
  申请人：Kuhn Klaus-Dieter

  公开号：US20060171986A1

  公开（公告）日：2006-08-03

  An antibiotic coating of implants is described, which is characterized in that the coating comprises at least one saturated, organic, hydrophobic, low molecular matrix former whose melting point is in the temperature range of 45° C. to 100° C., in which a low molecular, hydrophobic additive is dissolved and that an antibiotic/antibiotics is/are suspended in the mixture of matrix former and additive and/or in which an antibiotic/antibiotics miscible with a mixture of matrix former and additive is/are dissolved.

  描述了一种植入物抗生素涂层，其特征在于该涂层包括至少一种饱和的、有机的、疏水的、低分子基质前体，其熔点温度范围为 45°C 至 100°C，在基质前体中溶解有低分子疏水添加剂，抗生素/抗生素悬浮在基质前体和添加剂的混合物中，和/或在基质前体和添加剂的混合物中溶解有抗生素/抗生素。
• [EN] A METHOD FOR PROMOTING TISSUE REPAIR<br/>[FR] PROCEDE VISANT A PROMOUVOIR LA REPARATION TISSULAIRE
  申请人：DUMEX-ALPHARMA A/S

  公开号：WO1998022114A1

  公开（公告）日：1998-05-28

  (EN) A combination of a first compound of an oligo- or polysaccharide containing aminosugar units and a second compound of a sulfated mono-, di- or oligosaccharide as an agent for the enhancement of the healing of wounds in collagen containing tissues, including skin and bone and in mucosa. The first compound may be, e.g., chitosan, chitosans obtained by deacetylated of chitin to various degrees of deacetylation, chitosan derivatives, glycosaminoglycans including chondroitin, chondroitin sulfate, hyaluronic acid, dermatan sulfate and keratan sulfate; aminated dextrans including DEAE-dextran; aminated starch, aminated glycogen, aminated cellulose, aminated pectin, heparin, and salts, complexes, derivatives and mixtures thereof, and the second compound may be a disaccharide such as, e.g., sucrose, a sucrose derivative or a complex or a salt thereof, wherein the disaccharide is at least tetrasulfated. A very interesting combination is a combination of chitosan as the first compound and sucrose octasulfate as the second compound. Also disclosed is the use of such compounds as medicaments, pharmaceutical compositions containing such combinations and a method for the preparation of such combinations.(FR) L'invention concerne la combinaison d'un premier composé d'un oligo- ou polysaccharide, contenant des unités aminosucre, et d'un second composé d'un mono-, di- ou oligosaccharide sulfaté en tant qu'agent de promotion de la cicatrisation de blessures dans des tissus contenant du collagène, notamment la peau et les os, et dans les muqueuses. Le premier composé peut être, par exemple, du chitosane, des chitosanes obtenus par désacétylation de la chitine à divers degrés de désacétylation, des dérivés de chitosane, des glycosaminoglycanes comprenant la chondroïtine, le sulfate de chondroïtine, l'acide hyaluronique, le sulfate de dermatane et le sulfate de kératane, des dextranes aminés comprenant le dextrane-DEAE, l'amidon aminé, le glycogène aminé, la cellulose aminée, la pectine aminée, l'héparine et des sels, complexes, dérivés et mélanges de ceux-ci, et le second composé peut être un disaccharide tel que, par exemple, du sucrose, un dérivé de sucrose ou un complexe ou sel de celui-ci, le disaccharide étant au moins tétrasulfaté. On réalise une combinaison très intéressante avec du chitosane, en tant que premier composé, et de l'octasulfate de sucrose, en tant que second composé. L'invention concerne également l'utilisation de tels composés en tant que médicaments, des compositions pharmaceutiques contenant de telles combinaisons ainsi qu'un procédé de préparation de ces combinaisons.

  本发明涉及一种组合物，该组合物包括含有氨基糖单元的寡或多糖的第一化合物和一种含硫酸单、双或多糖的第二化合物，用作胶原蛋白含量组织中伤口愈合促进剂，包括皮肤和骨组织以及黏膜。第一化合物可以是壳聚糖、不同脱乙酰度的壳聚糖及其衍生物、氨基糖胺类，如玻尿酸、硫酸软骨素、透明质酸、皮肤硫酸软骨素和角质素；氨基葡聚糖，如DEAE-葡聚糖；氨基淀粉、氨基树胶、氨基纤维素、氨基果胶、肝素及它们的盐、复合物或衍生物及其混合物。第二化合物可以是一种四硫酸化的双糖，例如蔗糖、蔗糖衍生物或其复盐或盐。非常有趣的一种组合是壳聚糖作为第一化合物和蔗糖八硫酸酯作为第二化合物。此外，本发明还涉及这些化合物用作药物的用途、含此类组合物的药学制剂以及制备此类组合物的方法。
• PHENYL DERIVATIVE
  申请人：ONO Pharmaceutical Co., Ltd.

  公开号：EP2980072B1

  公开（公告）日：2018-04-25