(E)-N-[(4β-D-glucopyranosyloxy)-3-methoxyphenylmethyl]-8-methylnon-6-enamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-N-[(4β-D-glucopyranosyloxy)-3-methoxyphenylmethyl]-8-methylnon-6-enamide
• 英文别名: capsaicin 4-O-β-D-glucopyranoside；capsaicin-β-D-glucopyranoside；capsaicin-1-O-glucopyranoside；capsaicin-β-D-gucopyranoside；Capsaicin beta-D-Glucopyranoside；(E)-N-[[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]-8-methylnon-6-enamide
• 化学式: C₂₄H₃₇NO₈
• 分子量: 467.56
• InChiKey: HEYWYCJIIXVRPS-FDOPSVQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (E)-N-[(4β-D-glucopyranosyloxy)-3-methoxyphenylmethyl]-8-methylnon-6-enamide 反应 16.0h， 生成 D-葡萄糖 、 辣椒碱
  参考文献：
  名称：

  Kometani, Takashi; Tanimoto, Hidenori; Nishimura, Takahisa, Bioscience, Biotechnology and Biochemistry, 1993, vol. 57, # 12, p. 2192 - 2193

  摘要：

  DOI：
• 作为产物：
  描述：

  辣椒碱 在 2,4-二氯苯氧乙酸 、 6-糠氨基嘌呤 作用下， 反应 48.0h， 生成 (E)-N-[(4β-D-glucopyranosyloxy)-3-methoxyphenylmethyl]-8-methylnon-6-enamide
  参考文献：
  名称：

  Kometani, Takashi; Tanimoto, Hidenori; Nishimura, Takahisa, Bioscience, Biotechnology and Biochemistry, 1993, vol. 57, # 12, p. 2192 - 2193

  摘要：

  DOI：

文献信息

• Nanoparticle delivery system for targeted anti-obesity treatment
  申请人：UNIVERSITY OF WYOMING

  公开号：US10456467B2

  公开（公告）日：2019-10-29

  A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.

  本文描述了一种包括 TRPV1 激动剂的磁性纳米粒子以及制备和使用方法。磁响应药物可包括具有磁性纳米粒子 (MNPs) 和 TRPV1 蛋白激动剂的核心区域。此外，还可在核心区域周围形成由聚合物组成的外部涂层。磁响应药物可施用给受体，并通过外部磁场导向目标区域。
• Cannabinoid glycoside prodrugs and methods of synthesis
  申请人：Graphium Biosciences, Inc.

  公开号：US11207414B2

  公开（公告）日：2021-12-28

  The present invention relates to cannabinoid glycoside prodrugs suitable for site- and tissue-specific delivery of cannabinoid molecules. The present invention also relates to methods of forming the cannabinoid glycoside prodrugs through glycosyltransferase mediated glycosylation of cannabinoid molecules.

  本发明涉及适用于大麻素分子部位和组织特异性递送的大麻素苷原药。本发明还涉及通过糖基转移酶介导的大麻素分子糖基化形成大麻素苷原药的方法。
• NANOPARTICLE DELIVERY SYSTEM FOR TARGETED ANTI-OBESITY TREATMENT
  申请人：UNIVERSITY OF WYOMING

  公开号：US20160228548A1

  公开（公告）日：2016-08-11

  A magnetic nanoparticles including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.
• CANNABINOID GLYCOSIDE PRODRUGS AND METHODS OF SYNTHESIS
  申请人：Graphium Biosciences, Inc.

  公开号：US20220168428A1

  公开（公告）日：2022-06-02

  The present invention relates to cannabinoid glycoside prodrugs suitable for site- and tissue-specific delivery of cannabinoid molecules. The present invention also relates to methods of forming the cannabinoid glycoside prodrugs through glycosyltransferase mediated glycosylation of cannabinoid molecules.
• US9782481B2
  申请人：——

  公开号：US9782481B2

  公开（公告）日：2017-10-10