2-propyl α-L-cladinoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-propyl α-L-cladinoside
• 英文别名: (2S,3S,4R,6R)-4-methoxy-2,4-dimethyl-6-propan-2-yloxyoxan-3-ol
• 化学式: C₁₁H₂₂O₄
• 分子量: 218.293
• InChiKey: MSKKCPVKKQDKLI-ZRUFSTJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异丙醇 、 红霉素 在 硫酸 作用下， 反应 41.0h， 生成 2-propyl α-L-cladinoside 、 2-propyl β-L-cladinoside
  参考文献：
  名称：

  Synthesis of new, potent avermectin-like insecticidal agents

  摘要：

  4'-Modified avermectin derivatives were designed and synthesized. Some of the new synthetic compounds showed excellent in vivo bioactivity against cabbage larvae when compared to commercially available avermectin B-1a. In this synthesis, uncommon thioglycosyl sugar donors, prepared from the hydrolysis of natural antibiotics, proved compatible with sugar-macrolide synthesis in the presence of N-iodosuccinimide (NIS) or I-2 in N-methylpyrrolidone at room temperature. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.carres.2005.04.019

文献信息

• 6,11-3c-bicyclic 8a-azalide derivatives
  申请人：Bartizal Kenneth F.

  公开号：US20090149398A1

  公开（公告）日：2009-06-11

  Compounds of Formula (I), and pharmaceutically acceptable salts, esters, and prodrugs thereof: (I) are disclosed, wherein A, B, D, L, X, Y, Z and R 2′ , are described herein. The compounds exhibit antibacterial properties. The compounds of Formula (I) can be employed to treat or prevent bacterial infections as compounds per se or in the form of pharmaceutically acceptable salts, esters, or prodrugs. The compounds and their salts, esters, and prodrugs can also be employed as ingredients in pharmaceutical compositions, optionally in combination with other antibacterial agents, for the treatment of bacterial infections. Processes for making the compounds are also disclosed.

  公式（I）的化合物，及其药学上可接受的盐、酯和前药：在此披露，其中A、B、D、L、X、Y、Z和R2'在此描述。这些化合物具有抗菌特性。公式（I）的化合物可用于治疗或预防细菌感染，作为化合物本身或作为药学上可接受的盐、酯或前药的形式。这些化合物及其盐、酯和前药还可作为药物组成中的成分，可选择地与其他抗菌剂组合，用于治疗细菌感染。还披露了制备这些化合物的方法。
• 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS
  申请人：Sugimoto Tomohiro

  公开号：US20110237784A1

  公开（公告）日：2011-09-29

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，并且对于Hemophilus influenzae，或者对红霉素产生耐药性的细菌（例如耐药性肺炎球菌和链球菌）具有有效性。
• US8293715B2
  申请人：——

  公开号：US8293715B2

  公开（公告）日：2012-10-23
• Synthesis of new, potent avermectin-like insecticidal agents
  作者：Lijun Wei、Guohua Wei、Houcheng Zhang、Peng G. Wang、Yuguo Du

  DOI：10.1016/j.carres.2005.04.019

  日期：2005.7

  4'-Modified avermectin derivatives were designed and synthesized. Some of the new synthetic compounds showed excellent in vivo bioactivity against cabbage larvae when compared to commercially available avermectin B-1a. In this synthesis, uncommon thioglycosyl sugar donors, prepared from the hydrolysis of natural antibiotics, proved compatible with sugar-macrolide synthesis in the presence of N-iodosuccinimide (NIS) or I-2 in N-methylpyrrolidone at room temperature. (c) 2005 Published by Elsevier Ltd.