pleoniol A

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pleoniol A
• 英文别名: Pleoniol A；(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)-3,4,6-trimethyl-5-(3-methylbut-2-enoxy)phenoxy]oxane-3,4,5-triol
• 化学式: C₂₁H₃₂O₈
• 分子量: 412.48
• InChiKey: KZOUGFUYAKXPGM-YKGACUOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  29.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  128.84
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  pleoniol A 在 盐酸 作用下， 以 水 为溶剂， 反应 6.0h， 生成 葡萄糖
  参考文献：
  名称：

  Induced production of zinniol analogues by co-cultivation of two endophytic fungi in the same ecological niche

  摘要：

  Three zinniol analogues, pleoniols A-C (1-3), together with a known compound (4), were isolated from a mixed fermentation of two endophytic fungi, Pleosporales sp. F46 and Acremonium pilosum F47, both of which are found the pedicel of the medicinal plant Mahonia fortunei. High-performance liquid chromatography analysis showed that none of compounds 1-4 were detected when either one of the two fungi was cultured alone. The structures of compounds 1-4, including the absolute configurations, were deduced based on the interpretation of HRMS, NMR, and optical rotation data. Compounds 1-3 exhibited no antimicrobial efficacies against four Gram-positive or Gram-negative bacteria and two plant pathogenic fungi. Moreover, they demonstrated no obvious cytotoxic activities against four cancer cell lines, A549, MDA-MB-231, CT-26 and MCF-7. Our work indicates that the coculture of endophytes in the same ecological niche is an effective approach for promoting interspecies interaction and enriching chemical diversity.

  DOI：

  10.1016/j.phytol.2019.12.007

文献信息

• Induced production of zinniol analogues by co-cultivation of two endophytic fungi in the same ecological niche
  作者：Zi-Ru Wang、Hong-Xia Yang、Xiao-Ping Peng、Gang Li、Hong-Xiang Lou

  DOI：10.1016/j.phytol.2019.12.007

  日期：2020.2

  Three zinniol analogues, pleoniols A-C (1-3), together with a known compound (4), were isolated from a mixed fermentation of two endophytic fungi, Pleosporales sp. F46 and Acremonium pilosum F47, both of which are found the pedicel of the medicinal plant Mahonia fortunei. High-performance liquid chromatography analysis showed that none of compounds 1-4 were detected when either one of the two fungi was cultured alone. The structures of compounds 1-4, including the absolute configurations, were deduced based on the interpretation of HRMS, NMR, and optical rotation data. Compounds 1-3 exhibited no antimicrobial efficacies against four Gram-positive or Gram-negative bacteria and two plant pathogenic fungi. Moreover, they demonstrated no obvious cytotoxic activities against four cancer cell lines, A549, MDA-MB-231, CT-26 and MCF-7. Our work indicates that the coculture of endophytes in the same ecological niche is an effective approach for promoting interspecies interaction and enriching chemical diversity.