D-galactose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-galactose
• 英文别名: D-glactose；(2R,3S,4S,5R)-2,3,4,5-tetrahydroxyheptanal
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: ICRUBGXMNLFOTH-JRTVQGFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-O-β-D-galactopyranosyl (20S,24R)-3β,16β,25,29-tetrahydroxy-20,24-epoxycycloartane-29-O-β-D-glucopyranoside 在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 葡萄糖 、 D-galactose 、
  参考文献：
  名称：

  Cytotoxic triterpenoid saponins from Thalictrum atriplex

  摘要：

  Two new cycloartane glycosides, cycloatriosides A and B (1-2), and a new oleanolic acid glycoside, thaliatrioside A (3), along with7known triterpenoids (4-10) were isolated fromThalictrum atriplex. The structures of the new compounds were established as 3-O-beta-D-galactopyranosyl (20S, 24 R)-3 beta,16 beta,25,29-tetrahydroxy-20,24-epoxycycloartane-29-O-beta-D-glucopyranoside (1), 3-O-beta-D-glucopyranosyl-(1 -> 2)-alpha-arabinopyranosyl-3 beta,22 xi,30-trihydroxycycloart-24-en-21-oic acid alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranoside (2) and 3-O-[alpha-L-rhamnopyranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl]-oleanolic acid 28-O-beta-D-glucopyranosyl ester (3) on the basis of extensive NMR and HR-ESI-MS analyses, along with acid hydrolysis. Their cytotoxic activities against human lung cancer cells A549 and human breast cancer cells MDA-MB-231 were evaluated using MTT method. Compound9showed cytotoxicity against MDA-MB-231 cell line with the IC(50)value of 72.53 +/- 1.08 mu M.

  DOI：

  10.1080/14786419.2020.1834550

文献信息

• Steroidal Saponin from Polygonatum verticillatum
  作者：L. N. Gvazava、A. V. Skhirtladze

  DOI：10.1007/s10600-016-1859-1

  日期：2016.11

  New steroidal glycoside 1 was isolated by fractionation of total extracted compounds from rhizomes of Polygonatum verticillatum (Convallariaceae). Chemical transformations, physical constants, and spectral data characterized its structure as (25S)-spirost-5-en-3β-ol 3-O-β-D-glucopyranosyl-(1→3)-[β-Dfucopyranosyl-(1→2)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside.

  新型甾体苷1是从轮叶黄精（黄精科）的根茎中提取的总化合物的分级分离中获得的。通过化学转化、物理常数和光谱数据，其结构被鉴定为（25S）-螺甾-5-烯-3β-醇 3-O-β-D-吡喃葡萄糖基-(1→3)-[β-D-吡喃岩藻糖基-(1→2)]-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷。
• INSULIN DERIVATIVES FOR DIABETES TREATMENT
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150320837A1

  公开（公告）日：2015-11-12

  Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

  本文提供了一种“智能”递送治疗、预防或诊断药物的化合物、组合物和方法，例如通过葡萄糖感应胰岛素衍生物的葡萄糖介导递送胰岛素。胰岛素衍生物在体内结合血清白蛋白或聚集。在高血糖情况下，葡萄糖与葡萄糖感应元素的络合改变胰岛素衍生物的性质，导致其有效解离以释放胰岛素。这些化合物、组合物和方法提供了一种递送策略，用于自我调节和长期的糖尿病管理。
• US9867869B2
  申请人：——

  公开号：US9867869B2

  公开（公告）日：2018-01-16
• [EN] INSULIN DERIVATIVES FOR DIABETES TREATMENT<br/>[FR] DÉRIVÉS D'INSULINE POUR LE TRAITEMENT DU DIABÈTE
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014093696A2

  公开（公告）日：2014-06-19

  Compounds, compositions, and methods for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
• Cytotoxic triterpenoid saponins from <i>Thalictrum atriplex</i>
  作者：FanCheng Meng、XiaoDong Wei、Yan Sun、QingHong Zeng、Guowei Wang、XiaoZhong Lan、ZhiHua Liao、Min Chen

  DOI：10.1080/14786419.2020.1834550

  日期：2021.12.17

  Two new cycloartane glycosides, cycloatriosides A and B (1-2), and a new oleanolic acid glycoside, thaliatrioside A (3), along with7known triterpenoids (4-10) were isolated fromThalictrum atriplex. The structures of the new compounds were established as 3-O-beta-D-galactopyranosyl (20S, 24 R)-3 beta,16 beta,25,29-tetrahydroxy-20,24-epoxycycloartane-29-O-beta-D-glucopyranoside (1), 3-O-beta-D-glucopyranosyl-(1 -> 2)-alpha-arabinopyranosyl-3 beta,22 xi,30-trihydroxycycloart-24-en-21-oic acid alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranoside (2) and 3-O-[alpha-L-rhamnopyranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl]-oleanolic acid 28-O-beta-D-glucopyranosyl ester (3) on the basis of extensive NMR and HR-ESI-MS analyses, along with acid hydrolysis. Their cytotoxic activities against human lung cancer cells A549 and human breast cancer cells MDA-MB-231 were evaluated using MTT method. Compound9showed cytotoxicity against MDA-MB-231 cell line with the IC(50)value of 72.53 +/- 1.08 mu M.