(S)-2-allylamino-4-methylsulfanylbutyric acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-allylamino-4-methylsulfanylbutyric acid
• 英文别名: AMSB；(2S)-4-methylsulfanyl-2-(prop-2-enylamino)butanoic acid
• 化学式: C₈H₁₅NO₂S
• 分子量: 189.279
• InChiKey: ICHPRNNVJZNMNM-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-2-allylamino-4-methylsulfanylbutyric acid 、 Fmoc-O-叔丁基-L-谷氨酸 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Fmoc-Glu(O-t-Bu)-N(All)-Met-OH
  参考文献：
  名称：

  通过基于氢键替代物的α螺旋抑制HIV-1融合。

  摘要：

  DOI：

  10.1002/anie.200704227
• 作为产物：
  描述：

  N-Allylmethionine methyl ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 (S)-2-allylamino-4-methylsulfanylbutyric acid
  参考文献：
  名称：

  通过基于氢键替代物的α螺旋抑制HIV-1融合。

  摘要：

  DOI：

  10.1002/anie.200704227

文献信息

• Organic salts and their use as reagents in electrochemical reactions
  申请人：Callens Roland

  公开号：US20060049061A1

  公开（公告）日：2006-03-09

  Use of an organic compound salt of general formula A-XY   (I) wherein A means an organic residue, X means a charged group and Y means a counter-ion, as a reagent in an electrochemical reaction and organic compound salt corresponding to the formula R1R2ZC-T-Q-XY wherein X is a charged group, Y is a counter-ion, Z is a group capable of being substituted, R1 and R2 mean organic residues, T means a group containing a hetero atom selected among N-R4, O and S, and Q means a connecting group linking the hetero atom and the charged group.

  使用通式A-XY的有机化合物盐，其中A表示有机残基，X表示带电团，Y表示反离子，在电化学反应中作为试剂，以及符合以下公式的有机化合物盐R1R2ZC-T-Q-XY，其中X为带电团，Y为反离子，Z为可被取代的基团，R1和R2表示有机残基，T表示包含在N-R4，O和S中选择的杂原子的基团，Q表示连接杂原子和带电团的连接基团。
• Synthesis, molecular modeling and biological evaluation of novel 2-allyl amino 4-methyl sulfanyl butyric acid as α-amylase and α-glucosidase inhibitor
  作者：Kannan Balan、Perumal Perumal、Narayanan Sundarabaalaji、Thayumanavan Palvannan

  DOI：10.1016/j.molstruc.2014.09.086

  日期：2015.2

  In the present study 2-allyl amino 4-methyl sulfanyl butyric acid (AMSB) was synthesized in good yield. AMSB was characterized by Fourier transforms infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR) (H-1 and C-13) and Liquid chromatography mass spectrometry (LCMS). The radical scavenging activity and reducing power assay of AMSB was assessed using 1-1-diphenyl 2-picryl hydrazyl (DPPH), 2,2'-azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) (ABTS) and ferric ion reducing antioxidant power assay (FRAP) and was found to be 44.1, 34.71 and 41.7 mu g/ml respectively. The compound showed effective inhibition against alpha-amylase and alpha-glucosidase. AMSB was identified to be a reversible mixed noncompetitive inhibitor of alpha-amylase and alpha-glucosidase. The molecular docking study was carried out to evaluate the specific groove binding properties and affords valuable information of AMSB binding mode in the active site of alpha-glucosidase the study may lead to the which leads to the rational design of new class of antidiabetic drugs targeting alpha-glucosidase based on AMSB in near future. (C) 2014 Elsevier B.V. All rights reserved.
• ORGANIC SALTS AND THEIR USE AS REAGENTS IN ELECTROCHEMICAL REACTIONS
  申请人：Solvay SA

  公开号：EP1540037A1

  公开（公告）日：2005-06-15
• US7767073B2
  申请人：——

  公开号：US7767073B2

  公开（公告）日：2010-08-03
• [EN] ORGANIC SALTS AND THEIR USE AS REAGENTS IN ELECTROCHEMICAL REACTIONS<br/>[FR] SELS ORGANIQUES ET LEUR UTILISATION EN TANT QUE REACTIFS DANS DES REACTIONS ELECTROCHIMIQUES
  申请人：SOLVAY

  公开号：WO2004024991A1

  公开（公告）日：2004-03-25

  Use of an organic compound salt of general formula (I) : A-X Y wherein A means an organic residue, X means a charged group and Y means a counter-ion, as a reagent in an electrochemical reaction and organic compound salt corresponding to the formula R1R2ZC-T-Q-X Y wherein X is a charged group, Y is a counter-ion, Z is a group capable of being substituted, R1 and R2 mean organic residues, T means a group containing a hetero atom selected among N-R4, O and S, and Q means a connecting group linking the hetero atom and the charged group.