bisnaphthalimidopropylspermine tetrahydrobromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: bisnaphthalimidopropylspermine tetrahydrobromide
• 英文别名: 2-[3-[3-[4-[3-[3-(1,3-Dioxobenzo[de]isoquinolin-2-yl)propylamino]propylamino]butylamino]propylamino]propyl]benzo[de]isoquinoline-1,3-dione;hydrobromide
• 化学式: 4BrH*C₄₀H₄₈N₆O₄
• 分子量: 1000.51
• InChiKey: QZXKAVHAVUXMDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.16
• 重原子数：
  51
• 可旋转键数：
  21
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(3-hydroxypropyl)-1,8-naphthalimide 在 氢溴酸 、 caesium carbonate 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 bisnaphthalimidopropylspermine tetrahydrobromide
  参考文献：
  名称：

  The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives

  摘要：

  Bis-naphthalimidopropyl putrescine (BNIPPut), spermidine (BNIPSpd), spermine (BNIPSpm) and oxa-putrescine (BNIPOPut) were synthesised and their growth-inhibitory properties characterised. All these compounds except for BNIPOPut, showed high in vitro cytotoxic activity (with mean GI(50) values between 0.5 and 8.45 mu M) and selectivity against cancer cells derived from nine different human tumours. The increased content of nitrogen atoms in the linker chain of BNIPSpd and BNIPSpm significantly improved their aqueous dissolution properties with a marginal decrease in their cytotoxic activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00293-6

文献信息

• The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives
  作者：Paul Kong Thoo Lin、Valentin A. Pavlov

  DOI：10.1016/s0960-894x(00)00293-6

  日期：2000.7

  Bis-naphthalimidopropyl putrescine (BNIPPut), spermidine (BNIPSpd), spermine (BNIPSpm) and oxa-putrescine (BNIPOPut) were synthesised and their growth-inhibitory properties characterised. All these compounds except for BNIPOPut, showed high in vitro cytotoxic activity (with mean GI(50) values between 0.5 and 8.45 mu M) and selectivity against cancer cells derived from nine different human tumours. The increased content of nitrogen atoms in the linker chain of BNIPSpd and BNIPSpm significantly improved their aqueous dissolution properties with a marginal decrease in their cytotoxic activity. (C) 2000 Elsevier Science Ltd. All rights reserved.