N-benzhydrylpyridin-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzhydrylpyridin-4-amine
• 英文别名: N-(diphenylmethyl)-4-pyridinamine
• 化学式: C₁₈H₁₆N₂
• 分子量: 260.338
• InChiKey: JPBWQRWOVPEEAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氨基吡啶 、 二苯甲醇 在 cesiumhydroxide monohydrate 作用下， 反应 24.0h， 以85%的产率得到N-benzhydrylpyridin-4-amine
  参考文献：
  名称：

  Efficient and practical catalyst-free-like dehydrative N-alkylation of amines and sulfinamides with alcohols initiated by aerobic oxidation of alcohols under air

  摘要：

  We developed simple and practical N-alkylation reactions of amines and sulfinamides with primary and secondary alcohols by using only catalytic amounts of air as the initiator without adding any external catalysts. This method has advantages of simple conditions, easy operation, and comparatively wider scope of substrates, providing an efficient and green catalyst-free-like alcohol-based dehydrative N-alkylation method. Mechanistic studies revealed that air initiated the reactions by aerobic oxidation of the alcohols to the key initiating aldehydes or ketones in the presence of bases. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.11.016

文献信息

• Amino pyridine derivatives
  申请人：John Wyeth & Brother Limited

  公开号：US04180670A1

  公开（公告）日：1979-12-25

  Novel 4-pyridinamine derivatives having the formula ##STR1## [where R.sup.1 and R.sup.2 are aryl or heteroaryl (optionally linked together by a lower alkylene bridge) or one of R.sup.1 and R.sup.2 is aryl or heteroaryl and the other of R.sup.1 and R.sup.2 is lower alkyl or ar(lower)alkyl, R.sup.3 and R.sup.4 are each hydrogen or lower alkyl and n is 0 or 1] and their non-toxic acid addition salts are described. They show CNS activity and may be used as antidepressant drugs. Some also show stimulant activity. Novel intermediates having the formula ##STR2## are also described.

  描述了具有以下结构的新型4-吡啶胺衍生物 [其中R.sup.1和R.sup.2是芳基或杂环芳基（可选择通过较低的烷基桥连接在一起），或者R.sup.1和R.sup.2中的一个是芳基或杂环芳基，另一个是较低烷基或芳基（较低）烷基，R.sup.3和R.sup.4分别是氢或较低烷基，n为0或1]，以及它们的无毒酸盐。它们显示中枢神经系统活性，可用作抗抑郁药物。其中一些还显示兴奋活性。还描述了具有以下结构的新型中间体。
• US4180670A
  申请人：——

  公开号：US4180670A

  公开（公告）日：1979-12-25
• Efficient and practical catalyst-free-like dehydrative N-alkylation of amines and sulfinamides with alcohols initiated by aerobic oxidation of alcohols under air
  作者：Xiaohui Li、Shuangyan Li、Qiang Li、Xu Dong、Yang Li、Xiaochun Yu、Qing Xu

  DOI：10.1016/j.tet.2015.11.016

  日期：2016.1

  We developed simple and practical N-alkylation reactions of amines and sulfinamides with primary and secondary alcohols by using only catalytic amounts of air as the initiator without adding any external catalysts. This method has advantages of simple conditions, easy operation, and comparatively wider scope of substrates, providing an efficient and green catalyst-free-like alcohol-based dehydrative N-alkylation method. Mechanistic studies revealed that air initiated the reactions by aerobic oxidation of the alcohols to the key initiating aldehydes or ketones in the presence of bases. (C) 2015 Elsevier Ltd. All rights reserved.