β-(phenyltelluro)propionitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: β-(phenyltelluro)propionitrile
• 英文别名: 3-phenyltellanylpropanenitrile
• 化学式: C₉H₉NTe
• 分子量: 258.777
• InChiKey: PDZOUHZFTFAEET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.35
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  β-(phenyltelluro)propionitrile 在 sodium azide 、 zinc dibromide 作用下， 以 水 为溶剂， 反应 24.0h， 以74%的产率得到5-(2-phenyltellanylethyl)-2H-tetrazole
  参考文献：
  名称：

  Synthesis of novel selenium and tellurium-containing tetrazoles: a class of chalcogen compounds with antifungal activity

  摘要：

  We describe herein the synthesis and antifungal activity of new 5-arylchalcogenoalkyl-1H-tetrazoles 4. Arylchalcogenoalkyl-1H-tetrazoles 4 have been synthesized in high yields by reaction of arylchalcogenolate anions with chloronitriles 2, and subsequent [2+3] cycloaddition of resulting arylchalcogenoalkylnitriles 3 with sodium azide by zinc catalysis in aqueous solution. The obtained compound 4a was screened for antifungal activity and presented inhibitory property against seven fungal strains. This protocol is an efficient method to produce new selenium-nitrogen compounds with antifungal activity. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.04.040
• 作为产物：
  描述：

  联苯二碲 、 丙烯腈 在 三氢化钐 、 氯化锆(IV) 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以63%的产率得到β-(phenyltelluro)propionitrile
  参考文献：
  名称：

  Sm / ZrCl4 系统对二碲化物中 Te-Te 键的还原裂解：一种合成 β-碲酯（和腈）的新方法

  摘要：

  摘要 二芳基二碲化物可以通过由钐和四氯化锆在四氢呋喃中组成的体系方便地还原，生成芳基碲酸钐。这种新的碲酸盐阴离子物质与 α, β-不饱和酯（和腈）顺利反应，以良好的产率得到 β-碲酯（和腈）。

  DOI：

  10.1080/00397910008087320

文献信息

• An Effective Synthesis of β- Selenium and β- Tellurium Carbonyl Compounds Via Reaction of Diaryldiselenides Or Diarylditellurides with α,β- Unsaturated Carbonyl Compounds Induced by Low-Valent Titanium
  作者：Long-Hu Zhou、Yong-Min Zhang

  DOI：10.1080/00397919908085796

  日期：1999.2

  Abstract P-Selenium and β-tellurium carbonyl compounds have been prepared in good yield by reaction of diaryldiselenides or diarylditelluride with α,β-unsaturated carbonyl compounds induced by TiC14 / Sm /THF system under mild reaction conditions.

  摘要 在温和的反应条件下，二芳基二硒化物或二芳基二碲化物与α,β-不饱和羰基化合物在TiCl4/Sm/THF体系诱导下反应，制备了P-硒和β-碲羰基化合物，收率良好。
• Direct Michael addition to electron-deficient alkenes using diorganyl dichalcogenides (Te/S) and NaBH4/PEG-400
  作者：Gelson Perin、Elton L. Borges、Thiago J. Peglow、Eder J. Lenardão

  DOI：10.1016/j.tetlet.2014.08.101

  日期：2014.10

  Nucleophilic species of tellurium and sulfur were generated in situ from the reaction of the respective diorganyl dichalcogenides with NaBH4 in PEG-400 as solvent and selectively added to electron-deficient alkenes. Chalcogenolate anions were directly added at mild conditions by this simple procedure and in all cases furnished the respective Michael adducts in short reaction times and good yields. (C) 2014 Elsevier Ltd. All rights reserved.
• Li, Xue; Zhang, Songlin; Wang, Yulu, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 7, p. 1771 - 1773
  作者：Li, Xue、Zhang, Songlin、Wang, Yulu、Zhang, Yongmin

  DOI：——

  日期：——
• Tian, Fengshou; Zhang, Songlin; Wang, Yulu, Journal of Chemical Research - Part S, 2003, # 6, p. 360 - 361
  作者：Tian, Fengshou、Zhang, Songlin、Wang, Yulu

  DOI：——

  日期：——
• OHE, KOUICHI;TAKAHASHI, HIDETAKA;UEMURA, SAKAE;SUGITA, NOBUYUKI, J. CHEM. SOC. JAP., CHEM. AND IND. CHEM.,(1987) N 7, 1469-1474
  作者：OHE, KOUICHI、TAKAHASHI, HIDETAKA、UEMURA, SAKAE、SUGITA, NOBUYUKI

  DOI：——

  日期：——