methyl 5-chloro-5-methyl-4-nitrosohexanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 5-chloro-5-methyl-4-nitrosohexanoate
• 英文别名: methyl 5-chloro-4-nitroso-5-methylhexanoate
• 化学式: C₈H₁₄ClNO₃
• 分子量: 207.657
• InChiKey: OBPBRBJADWMMJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-<(3-aminopropyl)amino>-3-methyl-2-butanone oxime 、 methyl 5-chloro-5-methyl-4-nitrosohexanoate 以 二氯甲烷 为溶剂， 反应 3.0h， 以40%的产率得到1-carbomethoxy-3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime
  参考文献：
  名称：

  Synthesis of Functionalized 3,3,9,9-Tetramethyl-4,8-Diazaundecane-2,10-Dione Dioximes (Propylene Amine Oximes, PnAOs)

  摘要：

  The syntheses of several new derivatives of PnAO and their chloronitroso precursors are described. The PnAOs were prepared by an improvement of the reported general procedure. An unexpected product, an isooxalone, was formed while attempting to prepare 1-carbomethoxyl-PnAO.

  DOI：

  10.1080/00397919508011412
• 作为产物：
  描述：

  methyl 5-methyl-hex-4-enoate 在 盐酸 、 亚硝酸异戊酯 作用下， 反应 0.5h， 以41%的产率得到methyl 5-chloro-5-methyl-4-nitrosohexanoate
  参考文献：
  名称：

  Synthesis of Functionalized 3,3,9,9-Tetramethyl-4,8-Diazaundecane-2,10-Dione Dioximes (Propylene Amine Oximes, PnAOs)

  摘要：

  The syntheses of several new derivatives of PnAO and their chloronitroso precursors are described. The PnAOs were prepared by an improvement of the reported general procedure. An unexpected product, an isooxalone, was formed while attempting to prepare 1-carbomethoxyl-PnAO.

  DOI：

  10.1080/00397919508011412

文献信息

• Diagnostic imaging methods using rhenium and technetium complexes
  申请人：Bracco International B.V.

  公开号：US05688487A1

  公开（公告）日：1997-11-18

  Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

  新颖的方法、过程和与缺氧定位基团结合的金属配合物被揭示，所述金属优选为铼或锝的放射性核素；一种缺氧定位基团；以及一种络合配体，其中所述配体和所述放射性核素的结合具有大于蔗糖的细胞膜渗透性。
• Rhenium and technetium complexes containing a hypoxia-localizing moiety
  申请人：——

  公开号：US20020054853A1

  公开（公告）日：2002-05-09

  Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

  本发明公开了一种新的方法、过程和金属配合物，其附着于一种缺氧定位基团上，该基团包含一种金属，优选为锝或铼的放射性同位素；一种缺氧定位基团；和一种络合配体，其中所述配体和所述放射性同位素的组合具有细胞膜渗透性大于蔗糖的特性。
• RHENIUM AND TECHNETIUM COMPLEXES CONTAINING A HYPOXIA-LOCALIZING MOIETY
  申请人：——

  公开号：US20040010127A1

  公开（公告）日：2004-01-15

  Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

  本发明涉及一种新的方法、工艺和金属配合物，所述金属配合物附着于含有金属的低氧定位基团上，优选为锝或铼的放射性核素；所述低氧定位基团；以及络合配体，其中所述配体和所述放射性核素的结合具有细胞膜渗透性大于蔗糖。
• Rhenium and technetium complexes containing a hypoxia localizing moiety
  申请人：Bracco International B.V.

  公开号：US05808091A1

  公开（公告）日：1998-09-15

  Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

  本发明涉及一种与缺氧定位基团结合的金属络合物，包括金属，优选为锝或铼的放射性核素；缺氧定位基团；以及络合配体的新方法、新工艺和金属络合物，其中所述配体和所述放射性核素的组合具有细胞膜渗透性大于蔗糖的特点。
• Ramalingam K., Zeng W., Nanjappan P., Nowotnik D. P., Synth. Commun, 25 (1995) N 5, S 743-752
  作者：Ramalingam K., Zeng W., Nanjappan P., Nowotnik D. P.

  DOI：——

  日期：——