n-decyl t-butyl ether

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: n-decyl t-butyl ether
• 英文别名: 1-tert-butoxydecane；1-[(2-Methylpropan-2-yl)oxy]decane
• 化学式: C₁₄H₃₀O
• 分子量: 214.392
• InChiKey: JQJBQVRTSMGDJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (1-tert-Butoxy-decane-1-sulfonyl)-benzene 在 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 以97%的产率得到n-decyl t-butyl ether
  参考文献：
  名称：

  Julia, Marc; Uguen, Daniel; Zhang, Da, Australian Journal of Chemistry, 1995, vol. 48, # 2, p. 279 - 290

  摘要：

  DOI：

文献信息

• Zeolites Catalyze the Nazarov Reaction and the tert-Butylation of Alcohols by Stabilization of Carboxonium Intermediates
  作者：Antonio Leyva-Pérez、María Tejeda-Serrano、Sergio Sanz-Navarro、Finn Blake

  DOI：10.1055/s-0039-1690896

  日期：2020.7

  Zeolites are the most used catalysts worldwide in petrochemistry processes, with particular ability to stabilize carbocations. However, the use of zeolites in organic synthesis is still scarce. We show here that representative carboxonium-mediated organic reactions, such as the Nazarov cyclization and the tert-butylation of alcohols with tert-butyl acetate, typically performed with very strong acid

  沸石是全球范围内石化工艺中最常用的催化剂，具有稳定碳正离子的特殊能力。然而，在有机合成中仍很少使用沸石。我们在这里展示的是代表carboxonium介导的有机反应，如环化纳扎罗夫和叔醇与-butylation叔丁基乙酸酯，典型地在溶液中非常强的酸催化剂如三氟甲磺酸进行的，可以通过用简单的沸石催化高收率和选择性。铝硅酸盐骨架稳定了中间的碳氢化合物种类，并超越了溶液中对超酸质子的需求。
• Convenient preparations of t-butyl esters and ethers from t-butanol
  作者：Stephen W. Wright、David L. Hageman、Ann S. Wright、Lester D. McClure

  DOI：10.1016/s0040-4039(97)01792-9

  日期：1997.10

  A one-pot preparation of t-butyl esters and ethers is described that proceeds from the carboxylic acid or alcohol and t-butanol using only anhydrous magnesium sulfate and catalytic sulfuric acid as additional reagents. The method affords t-butyl esters and ethers in good yields and is applicable to a variety of substrates.

  描述了一种一锅法制备的叔丁基酯和醚，其仅使用无水硫酸镁和催化硫酸作为另外的试剂而由羧酸或醇和叔丁醇制得。该方法以良好的产率提供叔丁基酯和醚，并且适用于多种底物。
• COMPOUNDS EXHIBITING THROMBOPOIETIN RECEPTOR AGONISM
  申请人：Takayama Masami

  公开号：US20090318513A1

  公开（公告）日：2009-12-24

  A compound represented by the general formula (I): wherein R 1 is a hydrogen atom, a halogen atom, or the like; R 2 , R 3 , and R 4 are each independently a hydrogen atom, a halogen atom, C1-C15 alkyl optionally substituted with one or more C1-C12 alkyloxy or the like, or the like; R 5 is a hydrogen atom or the like; R 6 and R 7 are a hydrogen atom or the like; R 8 is C1-C3 alkyl or the like; R 9 is a hydrogen atom or the like), a prodrug, a pharmaceutically acceptable salt, or solvate thereof.

  一种由通式（I）表示的化合物：其中R1是氢原子、卤素原子或类似物；R2、R3和R4各自独立地是氢原子、卤素原子、C1-C15烷基（可选地用一个或多个C1-C12烷氧基或类似物取代）或类似物；R5是氢原子或类似物；R6和R7是氢原子或类似物；R8是C1-C3烷基或类似物；R9是氢原子或类似物。该化合物为一种前药、药物可接受的盐或其溶剂。
• Compounds exhibiting thrombopoietin receptor agonism
  申请人：Takayama Masami

  公开号：US20070043087A1

  公开（公告）日：2007-02-22

  A compound represented by the general formula (I): wherein R 1 is a hydrogen atom, a halogen atom, or the like; R 2 , R 3 , and R 4 are each independently a hydrogen atom, a halogen atom, C1-C15 alkyl optionally substituted with one or more C1-C12 alkyloxy or the like, or the like; R 5 is a hydrogen atom or the like; R 6 and R 7 are a hydrogen atom or the like; R 8 is C1-C3 alkyl or the like; R 9 is a hydrogen atom or the like), a prodrug, a pharmaceutically acceptable salt, or solvate thereof.

  化合物的一般式(I)表示的复合物，其中R1是氢原子、卤素原子或类似物；R2、R3和R4各自独立地是氢原子、卤素原子、C1-C15烷基（可选地用一个或多个C1-C12烷氧基或类似物取代）或类似物；R5是氢原子或类似物；R6和R7是氢原子或类似物；R8是C1-C3烷基或类似物；R9是氢原子或类似物。这是一个前药、药物可接受的盐或其溶剂。
• A Simple and Powerful tert-Butylation of Carboxylic Acids and Alcohols
  作者：Kosuke Namba、Chie Ogasa、Kimika Kayano

  DOI：10.1055/a-2161-9689

  日期：2024.1

  A simple and safe tert-butylation reaction was developed. Treatment of various free amino acids with 1.1 equivalents of bis(trifluoromethanesulfonyl)imide in tert-butyl acetate directly afforded tert-butyl esters with free amino groups quickly and in good yields. In addition, various carboxylic acids and alcohols without amino groups were converted into tert-butyl esters and ethers, respectively, in

  开发了一种简单且安全的叔丁基化反应。用1.1当量的双(三氟甲磺酰基)亚胺的乙酸叔丁酯溶液处理各种游离氨基酸，可以快速且高收率地直接得到具有游离氨基的叔丁酯。此外，在少量催化量的双(三氟甲磺酰基)亚胺存在下，各种不含氨基的羧酸和醇分别以高产率转化为叔丁基酯和醚。与传统方法相比，游离氨基酸、羧酸和醇的所有叔丁基化反应进行得更快并且产率更高。