4-hydroxyisoleucine γ-lactone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-hydroxyisoleucine γ-lactone
• 英文别名: 4-hydroxyisoleucinelactone；(3S,4R)-3-amino-4,5-dimethyloxolan-2-one
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: DXLUNIWVHZZSPK-DSDZBIDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydroxyisoleucine γ-lactone 在 lithium hydroxide 、 水 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 2.0h， 生成 (4S)-4-羟基异亮氨酸
  参考文献：
  名称：

  WO2006/117696

  摘要：

  公开号：
• 作为产物：
  描述：

  L-异亮氨酸 在 potassium tetrachloroplatinate 、 copper dichloride 作用下， 以 水 为溶剂， 反应 10.0h， 生成 反式-3-甲基-L-脯氨酸 、 4-hydroxyisoleucine γ-lactone 、 (3S,4S)-3-amino-4-ethyloxolan-2-one
  参考文献：
  名称：

  水中氨基酸的选择性功能化：通过催化CH键活化的合成方法。

  摘要：

  DOI：

  10.1021/ja016280f

文献信息

• Methods for enhancing the transport of glucose into muscle
  申请人：Lee S. Steve

  公开号：US20050226948A1

  公开（公告）日：2005-10-13

  The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

  本发明涉及生物活性化合物的新型组合物，包括 4-羟基异亮氨酸和一种或多种选自氨基酸、生物碱、苷、挥发油、皂甙、苷元、甘露聚糖、黄酮类、脂肪酸、维生素和维生素原、矿物质和碳水化合物组的化合物。优选地，生物活性化合物的新型组合物包括 4-羟基异亮氨酸和一种或多种选自精氨酸、天门冬氨酸、苏氨酸、丝氨酸、谷氨酸、脯氨酸、甘氨酸、丙氨酸、半胱氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、色氨酸、苯丙氨酸、鸟氨酸、脯氨酸、赖氨酸、组氨酸和γ-氨基丁酸的氨基酸。生物活性化合物的成分最好包括百分之十到百分之七十的 4-羟基异亮氨酸和百分之二十到百分之四十的其他氨基酸。本发明新型组合物的生物活性化合物可以从葫芦巴种子中提取、分离和/或萃取。从葫芦巴种子中提取生物活性化合物的优选方法包括以下步骤：(1) 提供多个葫芦巴种子；(2) 制备葫芦巴种子；(3) 从葫芦巴种子中提取生物活性化合物的新型组合物，包括初步提取步骤和二次提取步骤。研究发现，生物活性化合物组合物有助于恢复人类和动物健康的能量平衡，帮助控制体重，并通过帮助人体更有效地利用现有（即内源性）胰岛素来平衡血糖水平。
• Methods for enhancing the transport of glucose for balancing blood sugar levels
  申请人：Lee S. Steve

  公开号：US20050233013A1

  公开（公告）日：2005-10-20

  The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

  本发明涉及生物活性化合物的新型组合物，包括 4-羟基异亮氨酸和一种或多种选自氨基酸、生物碱、苷、挥发油、皂甙、苷元、甘露聚糖、黄酮类、脂肪酸、维生素和维生素原、矿物质和碳水化合物组的化合物。优选地，生物活性化合物的新型组合物包括 4-羟基异亮氨酸和一种或多种选自精氨酸、天门冬氨酸、苏氨酸、丝氨酸、谷氨酸、脯氨酸、甘氨酸、丙氨酸、半胱氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、色氨酸、苯丙氨酸、鸟氨酸、脯氨酸、赖氨酸、组氨酸和γ-氨基丁酸的氨基酸。生物活性化合物的成分最好包括百分之十到百分之七十的 4-羟基异亮氨酸和百分之二十到百分之四十的其他氨基酸。本发明新型组合物的生物活性化合物可以从葫芦巴种子中提取、分离和/或萃取。从葫芦巴种子中提取生物活性化合物的优选方法包括以下步骤：(1) 提供多个葫芦巴种子；(2) 制备葫芦巴种子；(3) 从葫芦巴种子中提取生物活性化合物的新型组合物，包括初步提取步骤和二次提取步骤。研究发现，生物活性化合物组合物有助于恢复人类和动物健康的能量平衡，帮助控制体重，并通过帮助人体更有效地利用现有（即内源性）胰岛素来平衡血糖水平。
• Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed
  申请人：Lee S. Steve

  公开号：US20050238738A1

  公开（公告）日：2005-10-27

  The present invention is directed to novel compositions of bio-active compounds comprising 4-hydroxyisoleucine and one or more compounds selected from the group of amino acids, alkaloids, glycosides, volatile oils, saponins, sapogenins, mannans, flavonoids, fatty acids, vitamins and provitamins, minerals, and carbohydrates. Preferably, the novel compositions of bio-active compounds include 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, proline, lysine, histidine, and gamma-aminobutyrate. The composition of bio-active compounds preferably include between about ten percent and about seventy percent of 4-hydroxyisoleucine and between about twenty percent and about forty percent of other amino acids. The bio-active compounds of the novel composition of the present invention may be derived, isolated, and/or extracted from Fenugreek seeds. A preferred method for extracting the bio-active compounds from Fenugreek seeds includes the steps of: (1) providing a plurality of Fenugreek seeds; (2) preparing the Fenugreek seeds; and (3) extracting a novel composition of bio-active compounds from the Fenugreek seeds, which include a preliminary extraction step and a secondary extraction step. The compositions of bio-active compounds have been found to be helpful in restoring healthy energy balance in humans and animals, aiding in weight management efforts, and for balancing blood sugar levels by way of assisting the body to make more efficient use of existing (i.e., endogenous) insulin.

  本发明涉及生物活性化合物的新型组合物，包括 4-羟基异亮氨酸和一种或多种选自氨基酸、生物碱、苷、挥发油、皂甙、苷元、甘露聚糖、黄酮类、脂肪酸、维生素和维生素原、矿物质和碳水化合物组的化合物。优选地，生物活性化合物的新型组合物包括 4-羟基异亮氨酸和一种或多种选自精氨酸、天门冬氨酸、苏氨酸、丝氨酸、谷氨酸、脯氨酸、甘氨酸、丙氨酸、半胱氨酸、缬氨酸、蛋氨酸、异亮氨酸、亮氨酸、色氨酸、苯丙氨酸、鸟氨酸、脯氨酸、赖氨酸、组氨酸和γ-氨基丁酸的氨基酸。生物活性化合物的成分最好包括百分之十到百分之七十的 4-羟基异亮氨酸和百分之二十到百分之四十的其他氨基酸。本发明新型组合物的生物活性化合物可以从葫芦巴种子中提取、分离和/或萃取。从葫芦巴种子中提取生物活性化合物的优选方法包括以下步骤：(1) 提供多个葫芦巴种子；(2) 制备葫芦巴种子；(3) 从葫芦巴种子中提取生物活性化合物的新型组合物，包括初步提取步骤和二次提取步骤。研究发现，生物活性化合物组合物有助于恢复人类和动物健康的能量平衡，帮助控制体重，并通过帮助人体更有效地利用现有（即内源性）胰岛素来平衡血糖水平。
• COMPOSITIONS AND METHODS USING TRIGONELLINE TO PRODUCE INTRACELLULAR NAD+
  申请人：Société des Produits Nestlé S.A.

  公开号：EP3993645A1

  公开（公告）日：2022-05-11
• COMPOSITIONS AND METHODS USING TRIGONELLINE TO PRODUCE INTRACELLULAR NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) FOR TREATING OR PREVENTING PHYSIOLOGICAL DISORDERS OR STATES
  申请人：Société des Produits Nestlé S.A.

  公开号：EP3993770A1

  公开（公告）日：2022-05-11