[EN] S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES<br/>[FR] COMPOSÉS DE S-NITROSOMERCAPTO ET DÉRIVÉS APPARENTÉS
申请人:GALLEON PHARMACEUTICALS INC
公开号:WO2009151744A1
公开(公告)日:2009-12-17
The present invention is directed to mercapto-based and S- nitrosomercapto-based SNO compounds and their derivatives, and their use in treating a lack of normal breathing control, including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions.
Analgesic Compounds, Compositions, and Uses Thereof
申请人:Mannion James C.
公开号:US20110224269A1
公开(公告)日:2011-09-15
The invention relates to compounds, compositions, and methods for diminishing pain in a subject in need thereof comprising administering the compounds and compositions herein described.
这项发明涉及化合物、组合物和方法,用于减轻需要的受试者的疼痛,包括给予所述的化合物和组合物。
Sulfur(VI) fluoride compounds and methods for the preparation thereof
申请人:The Scripps Research Institute
公开号:US10117840B2
公开(公告)日:2018-11-06
This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.
[EN] INTRANASAL PHARMACEUTICAL COMPOSITIONS OF CGRP INHIBITORS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES INTRANASALES D'INHIBITEURS DE CGRP
申请人:BIOHAVEN PHARM HOLDING CO LTD
公开号:WO2021127070A1
公开(公告)日:2021-06-24
Provided is pharmaceutical composition for intranasal delivery, wherein the pharmaceutical composition includes a therapeutically active ingredient including a CGRP inhibitor. Also provided is a method for delivering a CGRP inhibitor to a subject, wherein the method includes intranasally administering to the subject a composition including a therapeutically active component including a CGRP inhibitor.
Nitric Oxide Releasing Prodrugs of Therapeutic Agents
申请人:SATYAM Apparao
公开号:US20110263526A1
公开(公告)日:2011-10-27
The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.