salinosporamide H

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: salinosporamide H
• 英文别名: (1R,4S,5S)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-4-ethyl-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• 化学式: C₁₅H₂₁NO₄
• 分子量: 279.336
• InChiKey: SCJZQKFFYIGMCI-XWKQNIGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  starch 在 strain CNB₄₇₆ iron(III) sulfate 、 氧气 、 calcium carbonate 、 sodium bromide 、 potassium bromide 、 peptone 、 yeast extract 作用下， 以 水 为溶剂， 反应 144.0h， 生成 [3H]-Salinosporamide B 、 NPI-2053 、 salinosporamide H
  参考文献：
  名称：

  [3.2.0] Heterocyclic compounds and methods of using the same

  摘要：

  本发明涉及具有抗癌，抗炎和抗微生物特性的I-VI式化合物及其衍生物和类似物，以及包括其中一种或多种化合物及其衍生物或类似物的组合物。还公开了包含这些化合物的药物组合物以及使用公开的化合物或药物组合物治疗癌症，炎症和微生物感染的方法。

  公开号：

  US20050288352A1

文献信息

• Salt formulations for the fermentation of marine microorganisms
  申请人：Triphase Research and Development I Corp.

  公开号：US10011814B2

  公开（公告）日：2018-07-03

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.

  公开了用于海洋微生物发酵的生长培养基。培养基包括特定浓度的钾、钙、锶、硼酸盐和氟化物。另外，生长培养基还包括特定浓度的钴或特定浓度的维生素 B12。还公开了通过海洋微生物发酵生产某些所需化合物的方法。
• Methods of using [3.2.0] heterocyclic compounds and analogs thereof
  申请人：Palladino Michael

  公开号：US20070004676A1

  公开（公告）日：2007-01-04

  Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.
• [3.2.0] HETEROCYCLIC COMPOUNDS AND METHODS OF USING THE SAME
  申请人：Potts Christine Barbara

  公开号：US20080070969A1

  公开（公告）日：2008-03-20

  Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
• SALT FORMULATIONS FOR THE FERMENTATION OF MARINE MICROORGANISMS
  申请人：Lam Kin Sing

  公开号：US20080160590A1

  公开（公告）日：2008-07-03

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B 12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.
• METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF FOR TREATING INFECTIOUS DISEASES
  申请人：Palladino Michael

  公开号：US20080280968A1

  公开（公告）日：2008-11-13

  Disclosed are methods of treating infectious diseases comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.