1-methoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-methoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid
• 化学式: C₁₀H₁₉NO₃
• 分子量: 201.266
• InChiKey: KKJMEPPIFCANFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-methoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid 在 吡啶 、 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Ciprofloxacin-nitroxide hybrids with potential for biofilm control

  摘要：

  As bacterial biofilms display extreme tolerance to conventional antibiotic treatments, it has become imperative to develop new antibacterial strategies with alternative mechanisms of action. Herein, we report the synthesis of a series of ciprofloxacin-nitroxide conjugates and their corresponding methoxyamine derivatives in high yield. This was achieved by linking various nitroxides or methoxy-amines to the secondary amine of the piperazine ring of ciprofloxacin using amide bond coupling. Biological evaluation of the prepared compounds on preformed P. aeruginosa biofilms in flow cells revealed substantial dispersal with ciprofloxacin-nitroxide hybrid 25, and virtually complete killing and removal (94%) of established biofilms in the presence of ciprofloxacin-nitroxide hybrid 27. Compounds 25-28 were shown to be non-toxic in both human embryonic kidney 293 (HEK 293) cells and human muscle rhabdomyosarcoma (RD) cells at concentrations up to 40 mu M. Significantly, these hybrids demonstrate the potential of antimicrobial-nitroxide agents to overcome the resistance of biofilms to antimicrobials via stimulation of biofilm dispersal or through direct cell killing. Crown Copyright (C) 2017 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.06.058
• 作为产物：
  描述：

  3-羧基-PROXYL 、 二甲基亚砜 在 ferrous(II) sulfate heptahydrate 、 双氧水 作用下， 以 水 为溶剂， 反应 0.17h， 以91%的产率得到1-methoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid
  参考文献：
  名称：

  Ciprofloxacin-nitroxide hybrids with potential for biofilm control

  摘要：

  As bacterial biofilms display extreme tolerance to conventional antibiotic treatments, it has become imperative to develop new antibacterial strategies with alternative mechanisms of action. Herein, we report the synthesis of a series of ciprofloxacin-nitroxide conjugates and their corresponding methoxyamine derivatives in high yield. This was achieved by linking various nitroxides or methoxy-amines to the secondary amine of the piperazine ring of ciprofloxacin using amide bond coupling. Biological evaluation of the prepared compounds on preformed P. aeruginosa biofilms in flow cells revealed substantial dispersal with ciprofloxacin-nitroxide hybrid 25, and virtually complete killing and removal (94%) of established biofilms in the presence of ciprofloxacin-nitroxide hybrid 27. Compounds 25-28 were shown to be non-toxic in both human embryonic kidney 293 (HEK 293) cells and human muscle rhabdomyosarcoma (RD) cells at concentrations up to 40 mu M. Significantly, these hybrids demonstrate the potential of antimicrobial-nitroxide agents to overcome the resistance of biofilms to antimicrobials via stimulation of biofilm dispersal or through direct cell killing. Crown Copyright (C) 2017 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.06.058

文献信息

• Modified butyl rubber composition
  申请人：The Yokohama Rubber Co., Ltd.

  公开号：EP1777237A1

  公开（公告）日：2007-04-25

  A modified butyl rubber composition including a modified butyl rubber obtained by reacting a compound (a) having, in its molecule, a nitroxide free radical stable at an ordinary temperature in the presence of oxygen, a radical initiator (b), and a bifunctional or higher radical polymerizable monomer (c) or a modified butyl rubber composition containing a modified butyl rubber, obtained by reacting a compound (a) having, in its molecule, a nitroxide free radical stable at ordinary temperature in the presence of oxygen and a radical initiator (b), into which a bi- or more-functional radical polymerizable monomer (c) is compounded.

  一种改性丁基橡胶组合物，包括一种改性丁基橡胶，该改性丁基橡胶是通过使一种化合物（a）反应而得，该化合物（a）的分子中含有一种在常温下有氧条件下稳定的亚硝基自由基、一种自由基引发剂（b）和一种双官能团或更高官能团可聚合单体（c），或一种含有改性丁基橡胶的改性丁基橡胶组合物、将分子中含有在常温下有氧条件下稳定的亚硝基自由基的化合物（a）和自由基引发剂（b）与双官能团或更高官能团可聚合单体（c）复配反应而得。
• SILICON-CONTAINING RESIN COMPOSITION
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：EP3705534A1

  公开（公告）日：2020-09-09

  Provided are a silicon-containing resin composition with which it is possible to form a silica-based coating film in which generation of cracks is minimized, a method for forming a silica-based coating film using the silicon-containing resin composition, and a crack-free silica-based coating film formed using the silicon-containing resin composition. A silicon-containing resin composition including (A) a silicon-containing resin and (S) a solvent, wherein one or more selected from siloxane resins and polysilanes is used as the (A) silicon-containing resin, and the (S) solvent contains a cycloalkyl acetate having a specific structure. Cyclohexyl acetate is preferably used as the cycloalkyl acetate.

  本发明提供了一种含硅树脂组合物，使用该组合物可形成硅基涂膜，其中裂纹的产生减至最小；还提供了一种使用该含硅树脂组合物形成硅基涂膜的方法，以及一种使用该含硅树脂组合物形成的无裂纹硅基涂膜。含硅树脂组合物包括（A）含硅树脂和（S）溶剂，其中（A）含硅树脂使用硅氧烷树脂和聚硅烷中的一种或多种，（S）溶剂包含具有特定结构的环烷基乙酸酯。环烷基乙酸酯最好使用环己基乙酸酯。
• Compounds for the treatment of pathologies associated with aging and degenerative disorders
  申请人：Niedernhofer Laura J.

  公开号：US20120004263A1

  公开（公告）日：2012-01-05

  The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. “Inhibiting a sign of aging or degenerative disorder” means reducing the risk of occurrence, delaying the onset, slowing the progression, and/or reducing the severity and/or manifestation, of a sign of aging or degenerative disorder, and includes, but is not limited to, preventing the occurrence, development or progression of a sign of aging or degenerative disorder.
• RADICAL ORBITAL SWITCHING
  申请人：THE AUSTRALIAN NATIONAL UNIVERSITY

  公开号：US20160075732A1

  公开（公告）日：2016-03-17

  Described herein are distonic radical anion species of formula (I): RAD-L-NEG; wherein RAD is a group comprising a radical; NEG is a group comprising an anion, which is capable of bonding to a proton or other cation; L is a linker that links NEG to RAD; and the radical of RAD is not π-conjugated to the anion of NEG.
• [EN] RADICAL ORBITAL SWITCHING<br/>[FR] COMMUTATION ORBITALE RADICALAIRE
  申请人：UNIV AUSTRALIAN

  公开号：WO2014121327A1

  公开（公告）日：2014-08-14

  Described herein are distonic radical anion species of formula (I): RAD-L-NEG; wherein RAD is a group comprising a radical; NEG is a group comprising an anion, which is capable of bonding to a proton or other cation; L is a linker that links NEG to RAD; and the radical of RAD is not π-conjugated to the anion of NEG.