adipic Acid Hydrate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: adipic Acid Hydrate
• 英文别名: hexanedioic acid;hydrate
• 化学式: C₆H₁₀O₄*H₂O
• 分子量: 164.158
• InChiKey: UDAADYHCNRLOMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium sulbactam 、 benzyl chloromethyl adipate 在 四丁基溴化铵 作用下， 以 水 、 乙酸乙酯 、 丙酮 为溶剂， 生成 adipic Acid Hydrate
  参考文献：
  名称：

  Bis-esters of dicarboxylic acids with amoxicillin and certain

  摘要：

  1,4-环己二羧酸和烷二羧酸的抗菌双酯，其中酯基来源于不同的醇类；一种醇为羟甲基青霉素酸1,1-二氧化物，或其6-β-羟甲基或6-α-氨基甲基衍生物；另一种为6-[D-(2-氨基-2-(对羟基苯基)乙酰基)]青霉素酸（阿莫西林）；及其药用可接受盐；一种使用所述酯及其盐的方法，以及其制备方法。

  公开号：

  US04462934A1

文献信息

• 1,1-Alkanediol dicarboxylate linked antibacterial agents
  申请人：Pfizer, Inc.

  公开号：US04457924A1

  公开（公告）日：1984-07-03

  Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula ##STR1## where A is the residue of certain dicarboxyic acids, R.sup.3 is H or (C.sub.1 -C.sub.3), n is zero or 1 such that when n is zero R is P or B and R.sup.1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R.sup.1 is P and the other is B, and P is ##STR2## where R.sup.2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.

  有用的抗菌剂，其中通过1,1-烷二醇二羧酸酯连接了青霉素和/或β-内酰胺酶抑制剂，其化学公式为##STR1##，其中A是某些二羧酸的残基，R.sup.3是H或(C.sub.1-C.sub.3)，n是0或1，当n为0时，R是P或B，R.sup.1是某些酯的残基，H或其盐；当n为1时，R和R.sup.1中的一个为P，另一个为B，P为##STR2##，其中R.sup.2是H或某些酰基团，B是β-内酰胺酶抑制羧酸的残基；其使用方法、药物组合物及其生产中有用的中间体。
• Hydroalcoholic gel compositions for use with dispensers
  申请人：Gojo Industries, Inc.

  公开号：EP2460560A1

  公开（公告）日：2012-06-06

  A hydroalcoholic gel composition includes greater than about 40 weight percent of an alcohol, based upon the total weight of the alcoholic composition, a polyacrylate thickener, and an ester plug-preventing agent. The composition is suitable for use in dispensers, and exhibits reduced mis-directed output when the dispenser is actuated.

  一种水醇凝胶组合物包括大于约 40 重量百分比的酒精（基于酒精组合物的总重量）、聚丙烯酸酯增稠剂和酯类防堵剂。该组合物适用于分配器，在分配器启动时可减少误导输出。
• Anti-irritants
  申请人：Croda, Inc.

  公开号：US20030114520A1

  公开（公告）日：2003-06-19

  Alkoxylated esters of dicarboxylic or tricarboxylic acids have an anti-irritating activity measured as a reduction in intracellular leakage of sodium fluorescein of 15% or more at 1:50 dilution or 40% or more at 1:100 dilution from a test composition containing 5% of the alkoxylated ester. These alkoxylated esters are useful in cosmetic and personal care products, especially in products such as baby shampoos, hand dishwashing liquids and bubble bath preparations. A method of reducing irritation provides for application of an irritant with the alkoxylated esters to the subject in a personal care or cosmetic product.

  二羧酸或三羧酸的烷氧基化酯具有抗刺激性，具体表现为含 5%烷氧基化酯的测试组合物在 1:50 稀释时，荧光素钠的细胞内渗漏减少 15% 或更多，或在 1:100 稀释时减少 40% 或更多。这些烷氧基化酯可用于化妆品和个人护理产品，尤其是婴儿洗发水、洗手液和泡泡浴露等产品。一种减少刺激性的方法是在个人护理或化妆品中将含有烷氧基化酯的刺激性物质涂抹在受试者身上。
• Emulsion base for skin care compositions
  申请人：SaNogueira P. James

  公开号：US20050152931A1

  公开（公告）日：2005-07-14

  The present invention is directed to an emulsion base for formulating cosmetic and dermatological compositions. The emulsion base has particular surfactant and/or emulsifier ratios such that a wide range of compositions with varying forms and additional components can be formulated without changing the ratio or amount of the primary and/or co-surfactant/emulsifier in the emulsion base or the amount of the emulsion base in the final composition. The emulsion base can be used in a system of formulating cosmetic and dermatological compositions.

  本发明涉及一种用于配制化妆品和皮肤科组合物的乳液基质。该乳液基质具有特定的表面活性剂和/或乳化剂比例，因此可以配制出多种具有不同形式和附加成分的组合物，而无需改变乳液基质中主表面活性剂和/或辅助表面活性剂/乳化剂的比例或用量，也无需改变最终组合物中乳液基质的用量。乳液基质可用于配制化妆品和皮肤科组合物。
• Cosmetic compositions containing fluorescent colorants for natural skin appearance
  申请人：Elder T. Stewart

  公开号：US20060078518A1

  公开（公告）日：2006-04-13

  Cosmetic or personal care compositions which comprise at least one fluorescent colorant other than white and at least one non-fluorescent colorant, are useful in preparing colored cosmetic or personal care preparations providing an enhanced skin appearance.

  化妆品或个人护理组合物包含至少一种除白色以外的荧光着色剂和至少一种非荧光着色剂，可用于制备有色化妆品或个人护理制剂，提供更好的皮肤外观。