1-(3-chlorophenyl)-2,4,5-triphenyl-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3-chlorophenyl)-2,4,5-triphenyl-1H-imidazole
• 英文别名: 1-(3-Chlorophenyl)-2,4,5-triphenylimidazole；1-(3-chlorophenyl)-2,4,5-triphenylimidazole
• 化学式: C₂₇H₁₉ClN₂
• 分子量: 406.914
• InChiKey: KRPHRYLMOZAVDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Desyl-3-chlor-anilin 在 氨 作用下， 生成 1-(3-chlorophenyl)-2,4,5-triphenyl-1H-imidazole
  参考文献：
  名称：

  Bailey; McCombie, Journal of the Chemical Society, 1912, vol. 101, p. 2276

  摘要：

  DOI：

文献信息

• An Efficient, Solvent Free One Pot Synthesis of Tetra substitue dimidazoles Catalyzed by Nanocrystalline γ-alumina
  作者：Pallavi Shelke、Anjali Rajbhoj、Madhav Nimase、Gangaram Tikone、Bhaskar Zaware、Shridhar Jadhav

  DOI：10.13005/ojc/320427

  日期：2016.8.25

  spectrophotometer and high- resolution transmission electron microscopy These synthesized γ-Al 2 O 3 NPs were tested used as a catalyst for one pot synthesis of tetraaryl imidazole derivatives from the cyclodehydration and condensation of benzil, aromatic aldehyde, anilines and ammonium acetate under solvent free condition. This method has various advantages like convenient work-up procedure, environmentally

  通过电化学还原法成功地合成了γ-氧化铝纳米粒子（γ-Al2 O 3 NPs）。溴化四丙基铵的水溶液用作电解质和稳定剂。为了防止自发团聚并控制纳米颗粒的尺寸，对各种参数（例如电流密度，电极之间的距离和电解质浓度）进行了优化。由此合成的γ-Al2O3NPs通过复杂的分析技术进行了表征，包括X射线衍射，扫描电子显微镜，能量色散分光光度计和高分辨率透射电子显微镜。这些合成的γ-Al2 O 3 NPs被用作一锅催化剂。由苯甲醚，芳族醛的环脱水和缩合反应合成四芳基咪唑衍生物 无溶剂条件下的苯胺和乙酸铵。该方法具有多种优点，如后处理方便，对环境无害，反应时间短以及产率高。纳米晶γ-Al2 O 3催化剂具有易于获得，多次循环利用，非常简单的分离和生态友好的特点。
• Green Synthesis of 1,2,4,5-Tetrasubstituted and 2,4,5-Trisubstituted Imidazole Derivatives Involving One-pot Multicomponent Reaction
  作者：Ravi Bansal、Pradeep K. Soni、Anand K. Halve

  DOI：10.1002/jhet.3160

  日期：2018.6

  Sodium lauryl sulfate has been found convenient, versatile, and eco‐friendly catalyst for the synthesis of 1,2,4,5‐tetrasubstituted and 2,4,5‐trisubstituted imidazole derivatives by one‐pot multicomponent reactions at 80°C using water as solvent. This protocol afforded advantages, that is, the metal‐free reaction, purification of products by non‐chromatographic method, and excellent yields.

  月桂基硫酸钠被发现是一种方便，通用且环保的催化剂，可通过在80°C的条件下用水多锅法合成1,2,4,5-四取代和2,4,5-三取代的咪唑衍生物作为溶剂。该方案具有以下优点：无金属反应，通过非色谱法纯化产物和极佳的收率。
• Boehmite nanoparticles, an efficient green catalyst for the multi-component synthesis of highly substituted imidazoles
  作者：Ali Keivanloo、Mohammad Bakherad、Elahe Imanifar、Mahdi Mirzaee

  DOI：10.1016/j.apcata.2013.07.027

  日期：2013.10

  Boehmite nanoparticles (AlOOH NPs) was found to be a highly active and green catalyst for the synthesis of highly substituted imidazoles under solvent-free conditions. This one-pot procedure is very simple, and affords good to excellent yields. Furthermore, the catalyst shows good thermal stability and recyclability. The catalyst was recycled for five runs without an appreciable loss in its catalytic

  发现勃姆石纳米颗粒（AlOOH NPs）是在无溶剂条件下合成高度取代的咪唑的高活性绿色催化剂。这种一锅法的操作非常简单，并且收率良好。此外，该催化剂显示出良好的热稳定性和可循环性。将该催化剂循环使用五次，其催化活性没有明显损失。
• Catalyst‐free one‐pot synthesis of 2,4,5‐tri‐ and 1,2,4,5‐tetrasubstituted imidazoles
  作者：Priyanka V. Bandivadekar、Ganesh U. Chaturbhuj

  DOI：10.1002/jhet.4771

  日期：2024.3

  emphasizes catalyst-free 2,4,5-tri- and 1,2,4,5-tetra substituted imidazole synthesis using diversified aldehydes with benzil, ammonium acetate, or amines. Ammonium acetate plays a vital role as a reactant catalyst by dissociating into acetic acid to afford imine and diamine formation to ascertain the 2,4,5-tri- and 1,2,4,5-tetra substituted imidazoles. The key advantages of the current approach are efficient

  目前的工作重点是使用多种醛与苯偶酰、乙酸铵或胺进行无催化剂的 2,4,5-三取代和 1,2,4,5-四取代咪唑合成。乙酸铵作为反应物催化剂发挥着至关重要的作用，它可分解成乙酸，形成亚胺和二胺，从而确定 2,4,5-三取代和 1,2,4,5-四取代咪唑。目前方法的主要优点是高效、绿色、环保、简便，在80°C的温度下，在较短的反应时间内具有中等至优异的产率。乙醇：水作为溶剂使反应过程更加环保。总体而言，所描述的方法为有效和可持续合成取代咪唑提供了一条有前途的途径，其在医药、农用化学品和材料科学等各个领域具有广泛的应用。
• One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles in Ionic Liquid
  作者：Yu Wan、Gui-xiang Liu、Ling-ling Zhao、Hai-ying Wang、Shu-ying Huang、Liang-feng Chen、Hui Wu

  DOI：10.1002/jhet.1751

  日期：2014.5

  The four‐component condensation of benzil, aromatic aldehyde, primary amine, and ammonium acetate catalyzed by TFA in ionic liquid [Bpy]BF4 at 80°C provided 1,2,4,5‐tetrasubstituted imidazoles in moderate to high yields.