glycyl-L-phenylalanine benzyl ester hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glycyl-L-phenylalanine benzyl ester hydrochloride
• 英文别名: H-Gly-L-Phe-OBzl.HCl；H-Gly-Phe-OBzl*HCl；benzyl (2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoate;hydrochloride
• 化学式: C₁₈H₂₀N₂O₃*ClH
• 分子量: 348.829
• InChiKey: FPKCCDXOOANAJY-NTISSMGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  glycyl-L-phenylalanine benzyl ester hydrochloride 在 N-甲基吗啉 、 盐酸 、 氯甲酸乙酯 作用下， 以 1,4-二氧六环 为溶剂， 反应 9.5h， 生成 Z-Arg(NO2)-Gly-Pro-Pro-Gly-L-Phe-OBzl
  参考文献：
  名称：

  Shinoda, Ichizo; Nosho, Yasuharu; Otagiri, Ken, Agricultural and Biological Chemistry, 1986, vol. 50, # 7, p. 1785 - 1790

  摘要：

  DOI：
• 作为产物：
  描述：

  L-苯丙氨酸苄酯对甲苯磺酸盐 在 N-甲基吗啉 、 盐酸 、 氯甲酸乙酯 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 glycyl-L-phenylalanine benzyl ester hydrochloride
  参考文献：
  名称：

  Nosho, Jasuharu; Otagiri, Ken; Shinoda, Ichizo, Agricultural and Biological Chemistry, 1985, vol. 49, # 6, p. 1829 - 1838

  摘要：

  DOI：

文献信息

• Methionine.sup.5 -enkephalin sulfoxides and sulfones
  申请人：G. D. Searle & Co.

  公开号：US04144228A1

  公开（公告）日：1979-03-13

  Methionine.sup.5 -enkephalin sulfoxides and sulfones having agonist activity at opiate receptors are disclosed herein. These sulfoxides and sulfones are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

  本文披露了在鸟氨酸.sup.5-内啡肽的亚硫酸酯和亚砜中具有鸦片受体激动剂活性的化合物。这些亚硫酸酯和亚砜可用作镇痛剂、不成瘾的麻醉拮抗剂和抗腹泻剂。
• Synthesis and biological activity of new glycyrrhizic acid conjugates with amino acids and dipeptides
  作者：L. A. Baltina、R. M. Kondratenko、L. A. Baltina、N. Z. Baschenko、O. A. Pl’yasunova

  DOI：10.1134/s1068162009040141

  日期：2009.7

  New glycyrrhizic acid (GA) conjugates were synthesized with the use of tert-butyl esters of amino acids or benzyl esters of dipeptides; they contained two residues of L-amino acids (Met, Phe, Pro, and Ile or dipeptides Gly-Leu and Gly-Phe). Activation of GA carboxy groups was carried out with the help of N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, or N-hydroxybenzotriazole with dicyclohexylcarbodiimide. A proline-containing GA derivative is a low-toxic substance; it raises the level of agglutinins by 3.7 times in the blood of mice and 3 times that of hemolysins compared with the control. Dipeptide GA derivatives possess an expressed anti-HIV-1 activity in cultures of MT-4 cells and are 90-70 times less cytotoxic than azidothymidine. The selectivity index of the compounds exceeds those of GA by 110 and 34 times, respectively.
• Synthesis and characterization by 13C-CP-MAS- and high resolution 1H-, 13C-NMR of new ureido sugars, derivatives of methyl 2-amino-2-deoxy-β-d-glucopyranose and dipeptides
  作者：Andrzej Temeriusz、Bogusława Piekarska-Bartoszewicz、Iwona Wawer

  DOI：10.1016/s0008-6215(97)00236-x

  日期：1997.11

  Dipeptide ethyl and benzyl esters were used as amination agents in reaction with methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(4-nitrophenoxycarbonylamino)-beta-D-glucopyranoside(1). Ten new ureido sugars, derivatives of GlyAla, AlaGly, AlaAla, GlyVal, ValGly, LeuGly, PheGly, GlyPhe, and AlaPhe; were obtained. The new ureido sugars were studied by means of H-1- and C-13-NMR spectroscopy in solution, and C-13-CP-MAS-NMR in the solid-state. (C) 1997 Elsevier Science Ltd. All rights reserved.
• US4144228A
  申请人：——

  公开号：US4144228A

  公开（公告）日：1979-03-13