2-keto-3-deoxygluconate | 71564-62-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-keto-3-deoxygluconate
• 英文别名: 3-deoxy-L-threo-hex-2-ulosonic acid；(4S,5S)-4,5,6-trihydroxy-2-oxohexanoic acid
• CAS: 71564-62-0
• 化学式: C₆H₁₀O₆
• 分子量: 178.142
• InChiKey: WPAMZTWLKIDIOP-UCORVYFPSA-N

物化性质

• 沸点：
  467.5±45.0 °C(Predicted)
• 密度：
  1.582±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-keto-3-deoxygluconate 在 disodium hydrogenphosphate 、 柠檬酸 作用下， 反应 27.0h， 以1%的产率得到5-羟甲基-2-呋喃甲酸
  参考文献：
  名称：

  [EN] SYNTHESIS OF SUBSTITUTED FURANS
  [FR] SYNTHÈSE DE FURANES SUBSTITUÉS

  摘要：

  公开号：

  WO2021016220A3
• 作为产物：
  描述：

  4-deoxy-L-erythro-5-hexoseulose uronate 在 potassium chloride 、 alginate lyase rSjRed 、 sodium phosphate 、 2-巯基乙醇 、 还原型辅酶II(NADPH)四钠盐 作用下， 反应 24.0h， 生成 2-keto-3-deoxygluconate
  参考文献：
  名称：

  Functional identification of the 4-deoxy-L-erythro-5-hexoseulose uronate reductase from a brown alga, Saccharina japonica

  摘要：

  DOI：

  10.1016/j.bbrc.2021.01.090

文献信息

• Engineering stereocontrol into an aldolase-catalysed reaction
  作者：Henry J. Lamble、Michael J. Danson、David W. Hough、Steven D. Bull

  DOI：10.1039/b413255f

  日期：——

  A novel thermostable aldolase has been developed for synthetic application, and substrate engineering has been used to induce stereocontrol into aldol reactions of this naturally-promiscuous enzyme.

  针对合成应用，开发了一种新型热稳定醛缩酶，并采用了底物工程手段，在自然多底物酶的醛缩反应中引入立体控制。
• CONVERSION OF HEXURONIC ACID TO HEXARIC ACID
  申请人：Boer Harry

  公开号：US20120045804A1

  公开（公告）日：2012-02-23

  The present invention relates to a method and microbial host strain for converting a hexuronic acid to a hexaric acid. In particular, the invention relates to the con-version of D-galacturonic acid to meso-galactaric acid (mucic acid). The invention also concerns an isolated nucleotide sequence. According to the present method a microbial host strain genetically modified to express uronate dehydrogenase enzyme (EC 1.1.1.203) is contacted with a biomaterial comprising hexuronic acid and the con-version products are recovered. By using the recombinant microorganisms of the present invention it is possible to treat biomaterials comprising hexuronic acids and thereby decrease the amount of hexuronic acids released to the environment.

  本发明涉及一种将六羟基酸转化为六环酸的方法和微生物宿主菌株。具体而言，本发明涉及将D-半乳糖酸转化为中间-半乳糖酸（粘液酸）的转化。本发明还涉及一种分离的核苷酸序列。根据本方法，将经过基因修饰以表达尿酸脱氢酶酶（EC 1.1.1.203）的微生物宿主菌株与含有六羟基酸的生物材料接触，并回收转化产物。通过使用本发明的重组微生物，可以处理含有六羟基酸的生物材料，从而减少释放到环境中的六羟基酸的数量。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Cell-free and minimized metabolic reaction cascades for the production of chemicals
  申请人：Clariant Produkte (Deutschland) GmbH

  公开号：EP2700714A1

  公开（公告）日：2014-02-26

  Provided are enzymatic processes for the production of chemicals from carbon sources. In particular, a process for the production of a target chemical is disclosed using a cell-free enzyme system that converts carbohydrate sources to the intermediate pyruvate and subsequently the intermediate pyruvate to the target chemical.

  本文提供了利用碳源生产化学品的酶法工艺。特别是公开了一种利用无细胞酶系统生产目标化学品的工艺，该系统可将碳水化合物源转化为中间产物丙酮酸，然后再将中间产物丙酮酸转化为目标化学品。
• A METHOD OF INCREASING DROUGHT TOLERANCE IN A PLANT
  申请人：Brookhaven Science Associates, LLC

  公开号：EP3000873A1

  公开（公告）日：2016-03-30

  The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp, 638, to the plant.

  本发明涉及一种新型肠杆菌，即肠杆菌 638，以及其用途，例如，与未施用本发明方法或组合物的相同条件下生长的对照或野生型植物相比，本发明涉及一种方法，用于提高植物的生长、增加植物的生物量、提高植物的果实和/或种子产量、提高植物的耐病性和/或抗性，以及提高植物的耐旱性和/或抗性。这些方法包括向植物施用有效量的组合物，其中包括肠杆菌 638 的分离培养物。