8,4'-di-O-methylquercetin-3'-O-β-galactosyl-3-O-β-glucopyranoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8,4'-di-O-methylquercetin-3'-O-β-galactosyl-3-O-β-glucopyranoside
• 化学式: C₂₉H₃₄O₁₇
• 分子量: 654.579
• InChiKey: ONPJDJNOWVWWBC-GKRFZUMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.46
• 重原子数：
  46.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  267.66
• 氢给体数：
  9.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  8,4'-di-O-methylquercetin-3'-O-β-galactosyl-3-O-β-glucopyranoside 、 L-半胱氨酸甲酯盐酸盐 、 邻甲苯异硫氰酸酯 在 盐酸 、 水 、 吡啶 作用下， 以 吡啶 为溶剂， 反应 3.0h， 生成 methyl (4R)-3-[(2-methylphenyl)carbamothioyl]-2-[(1R,2S,3R,4R)-1,2,3,4,5-pentahydroxypentyl]-1,3-thiazolidine-4-carboxylate 、
  参考文献：
  名称：

  A new constituent against rheumatoid arthritis from the flower buds of Lonicera japonica

  摘要：

  In this study, two new compounds named as 8,4'-di-O-methylquercetin-3'-O-beta-galactosyl-3-O-beta-glucopyranoside (1) and 6-formyl-5-hydroxyl-4-ethyl-2-hydroxymethyl-1H-indene (2), were isolated from the flower buds of Lonicera japonica. Structures of compound 1 and 2 were determined by spectroscopic methods. Additionally, compound 1 showed therapeutic effects against rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) mice through significantly reducing the inflammatory responses in the joint tissues. These results suggested that compound 1 exerted potent chondroprotective and anti-inflammatory effects against RA.

  DOI：

  10.1016/j.phytol.2018.11.019

文献信息

• A new constituent against rheumatoid arthritis from the flower buds of Lonicera japonica
  作者：Yu Xiao、Bing Li、Jun Liu

  DOI：10.1016/j.phytol.2018.11.019

  日期：2019.2

  In this study, two new compounds named as 8,4'-di-O-methylquercetin-3'-O-beta-galactosyl-3-O-beta-glucopyranoside (1) and 6-formyl-5-hydroxyl-4-ethyl-2-hydroxymethyl-1H-indene (2), were isolated from the flower buds of Lonicera japonica. Structures of compound 1 and 2 were determined by spectroscopic methods. Additionally, compound 1 showed therapeutic effects against rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) mice through significantly reducing the inflammatory responses in the joint tissues. These results suggested that compound 1 exerted potent chondroprotective and anti-inflammatory effects against RA.