O-(6-aminohexyl)hydroxylamine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-(6-aminohexyl)hydroxylamine
• 英文别名: 1-Aminooxy-6-aminohexane
• 化学式: C₆H₁₆N₂O
• mdl: MFCD19212173
• 分子量: 132.206
• InChiKey: RNCIIUJIRBNSGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  米非司酮 、 O-(6-aminohexyl)hydroxylamine 以 乙醇 为溶剂， 反应 2.0h， 生成 11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one syn-O-(6-aminohexyl)oxime 、 11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one anti-O-(6-aminohexyl)oxime
  参考文献：
  名称：

  A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling

  摘要：

  We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

  DOI：

  10.1021/ja051294x

文献信息

• LOW-VOC ADDITIVES FOR EXTENDING WET EDGE AND OPEN TIMES OF COATINGS
  申请人：EASTMAN CHEMICAL COMPANY

  公开号：EP2082002A1

  公开（公告）日：2009-07-29
• [EN] LOW-VOC ADDITIVES FOR EXTENDING WET EDGE AND OPEN TIMES OF COATINGS<br/>[FR] Additifs à faible teneur en cov pour rallonger les durées limites de reprise et les délais de collage des revêtements
  申请人：EASTMAN CHEM CO

  公开号：WO2008048438A1

  公开（公告）日：2008-04-24

  [EN] A low VOC coating additive employing a water-dispersible rosin, a high glass transition temperature water-dispersible polymer, and optionally an amphiphilic component. The additive can be added to a coating to improve the performance characteristics of the coating, such as wiped wet edge time, open time, block resistance, gloss, scrub resistance, tack-free time, dry-to-touch time, and yellowing.
  [FR] La présente invention concerne un additif pour revêtement à faible teneur en COV utilisant une colophane dispersible dans l'eau, un polymère dispersible dans l'eau à température de transition vitreuse élevée et facultativement un composant amphiphile. L'additif peut être ajouté à un revêtement pour améliorer les caractéristiques de performance du revêtement, telles que le temps limite de reprise, le délai de collage, la résistance à l'adhérence, le brillant, la résistance au frottement, le temps de séchage pour être non collant, le temps pour devenir sec au toucher et le jaunissement.
• [EN] METHODS AND COMPOSITIONS FOR IMPROVED LABELING OF TARGETING PEPTIDES<br/>[FR] PROCÉDÉS ET COMPOSITIONS DE MARQUAGE AMÉLIORÉ DE PEPTIDES DE CIBLAGE
  申请人：IMMUNOMEDICS INC

  公开号：WO2016077061A2

  公开（公告）日：2016-05-19

  The present application discloses compositions and methods of synthesis and use of labeled targeting peptides, such as octreotide, octreotate, or other somatostatin analogs or derivatives. The targeting peptide may be labeled with a therapeutic or diagnostic isotope, such as 61Cu, 62Cu, 64Cu, 67Cu, 18F, 19F, 66Ga, 67Ga, 68Ga, 72Ga, 111In, 177Lu, 44Sc, 47Sc, 86Y, 88Y, 90Y, 45Ti or 89Zr, preferably 18F or 19F. More preferably, the targeting peptide is NOTA-octreotate, NOTA-MPAA-octreotate, pyridine-NOTA-octreotate or triazole-NOTA-octreotate. The labeled targeting peptides may be used for detection, diagnosis, imaging and/or treatment of sst2+ tumors, such as neuroendocrine tumors.