6'sialyllactose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6'sialyllactose
• 英文别名: 3-deoxy-Non2ulo5NAc-onic(?2-6)Gal(b1-4)Glc；(2R,4S,5R,6R)-5-acetamido-4-hydroxy-6-(1,2,3-trihydroxypropyl)-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]oxane-2-carboxylic acid
• 化学式: C₂₃H₃₉NO₁₉
• 分子量: 633.558
• InChiKey: TYALNJQZQRNQNQ-FLNYRALQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.8
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  335
• 氢给体数：
  13
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  Lactose 、 在 NaOAc buffer 作用下， 以 水 为溶剂， 反应 5.0h， 以2.5%的产率得到6'sialyllactose
  参考文献：
  名称：

  寡糖合成中的区域选择性转糖基化：各种来源的β-半乳糖苷酶和唾液酸酶的比较。

  摘要：

  N-乙酰-乳糖胺（β-D-Galp-（1-> 4）-D-Glc pNAc）是利用对硝基苯基β- D-吡喃半乳糖苷为供体。同样，使用各种来源的唾液酸酶，将α-（2-→8）-连接的唾液酸二聚体或唾液酸的对硝基苯基糖苷中的唾液酸基转糖基化为N-乙酰基-乳糖胺。当使用来自产气荚膜梭菌，脲节杆菌或霍乱弧菌的唾液酸酶时，区域选择性地获得α-（2-→6）-连接的唾液酸N-乙酰基-乳糖胺。相反，当使用来自新城疫病毒的唾液酸酶时，区域选择性地获得α-（2-→3）-连接的异构体。

  DOI：

  10.1016/0008-6215(94)84201-9

文献信息

• Composition comprising Siallylactose for use in enhancing learning skills and memory function
  申请人：NESTEC S.A.

  公开号：US11528928B2

  公开（公告）日：2022-12-20

  This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3′-Siallylactose (3′-SL) and 6′-Siallylactose (6′-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

  本发明涉及一种营养组合物的用途，该营养组合物包含增强哺乳动物认知发展和学习技能的硅烷基化低聚糖。该营养组合物包含3′-烯丙基低聚糖（3′-SL）和6′-烯丙基低聚糖（6′-SL），其重量比在10:1和1:10之间，专门用于通过增加所述个体大脑中的硅铝酸（Neu5Ac）浓度来提高其学习技能和/或增强其记忆功能。
• COMPOSITION COMPRISING SIALLYLLACTOSE FOR USE IN ENHANCING LEARNING SKILLS AND MEMORY FUNCTION
  申请人：NESTEC S.A.

  公开号：US20180064152A1

  公开（公告）日：2018-03-08

  This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3′-Siallylactose (3′-SL) and 6′-Siallylactose (6′-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.
• A NUTRITIONAL COMPOSITION FOR USE TO ENHANCE ATTENTION AND/OR REDUCE IMPULSIVITY
  申请人：SOCIETE DES PRODUiTS NESTLE S.A.

  公开号：US20200121702A1

  公开（公告）日：2020-04-23

  Use of a sialyllactose, or a nutritional composition comprising a sialyllactose, to enhance attention and/or to decrease impulsivity in a subject.
• COMPOSITIONS COMPRISING SIALYLATED OLIGOSACCHARIDES FOR USE IN INFANTS OR YOUNG CHILDREN TO PREVENT LATER IN LIFE OBESITY OR RELATED COMORBIDITIES AND PROMOTE A HEALTHY GROWTH
  申请人：NESTEC S.A.

  公开号：US20210205340A1

  公开（公告）日：2021-07-08

  The present invention relates to a nutritional composition comprising at least one sialylated oligosaccharide, for use in reducing and/or avoiding excessive fat mass accumulation, in preventing the associated later in life health disorders like later in life obesity and related comorbidities, in reducing and/or controlling food intake and/or in promoting a healthy growth in an infant or a young child.
• COMPOSITIONS COMPRISING HUMAN MILK OLIGOSACCHARIDES FOR USE IN INFANTS OR YOUNG CHILDREN TO PREVENT OR TREAT A HEALTH DISORDER BY INCREASING GLP-1 SECRETION
  申请人：NESTEC S.A.

  公开号：US20210205341A1

  公开（公告）日：2021-07-08

  The present invention relates to a nutritional composition comprising at least one human milk oligosaccharide for use in preventing and/or treating a health disorder in an infant or young child by increasing GLP-1 in said infant or young child.