(N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide
• 英文别名: 4-bromo-N-[methyl-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]carbamothioyl]benzamide
• 化学式: C₁₅H₁₉BrN₂O₆S
• 分子量: 435.296
• InChiKey: JHGZCARTUJTTFD-WJVRHOARSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide 、 copper(II) sulfate 以 乙醇 、 水 、 异丙醇 为溶剂， 以70%的产率得到[Cu((N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide)2]SO4
  参考文献：
  名称：

  Synthesis and antibacterial activity of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide chelate complex with copper(II) sulfate

  摘要：

  Reactions of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide with copper(II) sulfate in the ratios 1: 1 and 2: 1 affords the corresponding chelate complexes of the metal. Their structure was proved by high resolution mass spectrometry. The complex of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide with copper(II) sulfate (ratio 1:1) exhibits pronounced antibacterial activity.

  DOI：

  10.1134/s1070363211060168

文献信息

• Synthesis and antibacterial activity of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide chelate complex with copper(II) sulfate
  作者：A. I. Il’in、I. V. Kulakov、N. V. Leonova、S. S. Kasymbekova、O. V. Shchukina、D. V. Barinov

  DOI：10.1134/s1070363211060168

  日期：2011.6

  Reactions of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide with copper(II) sulfate in the ratios 1: 1 and 2: 1 affords the corresponding chelate complexes of the metal. Their structure was proved by high resolution mass spectrometry. The complex of (N-1-methylglucosaminocarbonothioyl)-4-bromobenzamide with copper(II) sulfate (ratio 1:1) exhibits pronounced antibacterial activity.