tetra N-benzoyl-kanamycin A

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tetra N-benzoyl-kanamycin A
• 英文别名: (1S)-N,N'-dibenzoyl-O⁴-(3-benzoylamino-3-deoxy-α-D-glucopyranosyl)-O⁶-(6-benzoylamino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-streptamine；(1S)-N,N'-Dibenzoyl-O⁴-(3-benzoylamino-3-desoxy-α-D-glucopyranosyl)-O⁶-(6-benzoylamino-6-desoxy-α-D-glucopyranosyl)-2-desoxy-streptamin；N-[[(2R,3S,4S,5R,6R)-6-[(1R,2R,3S,4R,6S)-4,6-dibenzamido-3-[(2S,3R,4S,5S,6R)-4-benzamido-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl]benzamide
• 化学式: C₄₆H₅₂N₄O₁₅
• 分子量: 900.937
• InChiKey: UXCQCWDQDWWSQA-NZUPULHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  65
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  295
• 氢给体数：
  11
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 水 、 苯甲酰氯 作用下， 生成 tetra N-benzoyl-kanamycin A
  参考文献：
  名称：

  Ogawa et al., Journal of the Agricultural Chemical Society of Japan, 1959, vol. 23, p. 289,305

  摘要：

  DOI：

文献信息

• Selective Inhibition of Bacterial and Human Topoisomerases by <i>N</i>-Arylacyl <i>O</i>-Sulfonated Aminoglycoside Derivatives
  作者：Amanda M. Fenner、Lisa M. Oppegard、Hiroshi Hiasa、Robert J. Kerns

  DOI：10.1021/ml3004507

  日期：2013.5.9

  Numerous therapeutic applications have been proposed for molecules that bind heparin-binding proteins. Development of such compounds has primarily focused on optimizing the degree and orientation of anionic groups on a scaffold, but utility of these polyanions has been diminished by their typically large size and nonspecific interactions with many proteins. In this study, N-arylacyl O-sulfonated aminoglycosides were synthesized and evaluated for their ability to selectively inhibit structurally similar bacterial and human topoisomerases. It is demonstrated that the structure of the aminoglycoside and of the N-arylacyl moiety imparts selective inhibition of different topoisomerases and alters the mechanism. The results here outline a strategy that will be applicable to identifying small, structurally defined oligosaccharides that bind heparin-binding proteins with a high degree of selectivity.
• Ogawa et al., Journal of the Agricultural Chemical Society of Japan, 1959, vol. 23, p. 289,305
  作者：Ogawa et al.

  DOI：——

  日期：——