forsythoneoside A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: forsythoneoside A
• 化学式: C₅₆H₆₂O₃₁
• 分子量: 1231.09
• InChiKey: YOJRRFWDZWDERW-KPERRZHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  87.0
• 可旋转键数：
  15.0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  503.72
• 氢给体数：
  18.0
• 氢受体数：
  31.0

反应信息

• 作为反应物：
  描述：

  forsythoneoside A 在 盐酸 作用下， 以 水 为溶剂， 反应 3.0h， 生成 L-鼠李糖 、 葡萄糖
  参考文献：
  名称：

  Forsythoneosides A–D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa

  摘要：

  Forsythoneosides A-D (1-4), four unusual adducts of a flavonoid unit fused to a phenylethanoid glycoside through a pyran ring or carbon-carbon bond, and four new phenylethanoid glycosides (5-8) were isolated from the fruits of Forsythia suspensa, together with nine known compounds. The structures of 1-8, including their absolute configurations, were elucidated by spectroscopic data as well as experimental and calculated electronic circular dichroism analysis. Compounds 2 and 4 inhibited PC12 cell damage induced by rotenone, and increased cell viability from 53.9 +/- 7.1% to 70.1 +/- 4.0% and 67.9 +/- 5.2% at 0.1 mu M, respectively.

  DOI：

  10.1021/acs.jnatprod.5b00372