trans-2-hexenyl 5-aminolevulinate hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-2-hexenyl 5-aminolevulinate hydrochloride
• 英文别名: [(E)-hex-2-enyl] 5-amino-4-oxopentanoate;hydrochloride
• 化学式: C₁₁H₁₉NO₃*ClH
• 分子量: 249.738
• InChiKey: UIMYUTFWSKEOKR-FXRZFVDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.62
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  69.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  反式-2-已烯-1-醇 在 N,N-二甲基甲酰胺 氯化亚砜 作用下， 反应 13.5h， 以47%的产率得到trans-2-hexenyl 5-aminolevulinate hydrochloride
  参考文献：
  名称：

  WO2008/2087

  摘要：

  公开号：

文献信息

• Unsaturated Alkyl Esters of 5-Aminolevulinic Acid, their Preparation and their Use
  申请人：Oh Jonghoon

  公开号：US20090176881A1

  公开（公告）日：2009-07-09

  Disclosed are unsaturated alkyl esters of 5-aminovulinic acid of the following chemical formula 1, or pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof. [Chemical Formula I] NH 2 —CH 2 —CO—CH 2 —CH 2 —CO—O—R wherein, R is a group selected from a group consisting of 2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, cis-2-pentenyl, cis-3-hexenyl, cis-4-hexenyl, and trans-2-hexenyl. Also, a pharmaceutical composition comprising the unsaturated alkyl ester of 5-aminovulinic acid or a salt thereof as an active ingredient is provided. This pharmaceutical composition is easily absorbed transdermally and is of low cytotoxicity. Featuring no amino-protecting processes, the method guarantees high production yields.

  本发明揭示了以下化学式1的5-氨基丙酮酸不饱和烷基酯或其药学上可接受的盐，以及其制备方法和用途。[化学式I] NH2-CH2-CO-CH2-CH2-CO-O-R，其中R是选择自2-丙烯基，3-丁烯基，4-戊烯基，5-己烯基，顺式-2-戊烯基，顺式-3-己烯基，顺式-4-己烯基和反式-2-己烯基的基团中的一种。此外，还提供了一种含有5-氨基丙酮酸不饱和烷基酯或其盐作为活性成分的制药组合物。该制药组合物易于经皮吸收，细胞毒性低。该方法不需要氨保护过程，保证高产率。
• UNSATURATED ALKYL ESTERS OF 5-AMINOLEVULINIC ACID, THEIR PREPARATION AND THEIR USE
  申请人：Industry Foundation of Chonnam National University

  公开号：EP2032526B1

  公开（公告）日：2012-10-10
• US8198325B2
  申请人：——

  公开号：US8198325B2

  公开（公告）日：2012-06-12
• [EN] UNSATURATED ALKYL ESTERS OF 5-AMINOLEVULINIC ACID, THEIR PREPARATION AND THEIR USE<br/>[FR] ESTERS ALKYLIQUES INSATURÉS DE L'ACIDE 5-AMINOLÉVULINIQUE, PRÉPARATION ET UTILISATION CORRESPONDANTES
  申请人：UNIV NAT CHONNAM IND FOUND

  公开号：WO2008002087A1

  公开（公告）日：2008-01-03

  [EN] Disclosed are unsaturated alkyl esters of 5- aminovulinic acid of the following chemical formula 1, or pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof. [Chemical Formula I] NH₂-CH₂-CO-CH₂-CH₂-CO-O-R wherein, R is a group selected from a group consisting of 2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, cis-2-pentenyl, cis-3-hexenyl, cis-4-hexenyl, and trans-2-hexenyl. Also, a pharmaceutical composition comprising the unsaturated alkyl ester of 5-aminovulinic acid or a salt thereof as an active ingredient is provided. This pharmaceutical composition is easily absorbed transdermally and is of low cytotoxicity. Featuring no amino -protecting processes, the method guarantees high production yields.
  [FR] Cette invention concerne des esters alkyliques insaturés de l'acide 5-aminovulinique représentés par la formule chimique suivante, ou des sels pharmaceutiquement acceptables de ceux-ci, ainsi qu'un procédé permettant de les préparer et de les utiliser. [Formule chimique] NH₂-CH₂-CO-CH₂-CH₂-CO-O-R dans laquelle, R représente un groupe choisi parmi les groupes: 2-propényle, 3-butényle, 4-pentényle, 5-hexényle, cis-2-pentényle, cis-3-hexényle, cis-4-hexényle, et trans-2-hexényle. En outre, cette invention concerne une composition pharmaceutique comprenant l'ester alkylique insaturé de l'acide 5-aminovulinique ou un sel de celui-ci en tant que principe actif. La composition pharmaceutique décrite dans cette invention est facilement absorbée de manière transdermique et elle présente une faible cytotoxicité. Le procédé décrit dans cette invention ne comprenant aucun processus amino-protecteur, il assure des rendements de production élevés.
• [EN] METATHETIC PRODUCTION OF FUNCTIONALIZED POLYMERS<br/>[FR] PRODUCTION MÉTATHÉTIQUE DE POLYMÈRES FONCTIONNALISÉS
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2009009158A2

  公开（公告）日：2009-01-15

  A process for preparing a functionalized polymer, the steps of the process involving contacting a metathesis catalyst under metathesis conditions with a composition comprising: (a) at least one ethylenically unsaturated polymer characterized in that the unsaturated polymer is substantially immune to metathetic degradation; (b) at least one functionalized ethylene containing cyclic or acyclic reagent compound, wherein the ethylenically unsaturated polymer and the functionalized ethylene containing cyclic or acyclic reagent compound have a combined degree of substitution of 4 or less than 4; and (c) optionally one or more solvents or diluents, and recovering the resulting functionalized polymeric reaction product.