3'-O-anthraniloyl-2'-deoxyadenosine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 3'-O-anthraniloyl-2'-deoxyadenosine
• 英文别名: [(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] 2-aminobenzoate
• 化学式: C₁₇H₁₈N₆O₄
• 分子量: 370.368
• InChiKey: VBGJCIBUKVKTLR-YNEHKIRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  靛红酸酐 、 2'-脱氧腺苷 生成 3'-O-anthraniloyl-2'-deoxyadenosine 、 5'-O-anthraniloyl-2'-deoxyadenosine
  参考文献：
  名称：

  Aminoacyl-tRNA Analogues; Synthesis, Purification and Properties of 3^′-Anthraniloyl Oligoribonucleotides

  摘要：

  Reaction of isatoic anhydride with adenosine, adenosine 5'-phosphate, oligoribonucleotides or with the E. coli tRNA(Val) led to attachment of an anthraniloyl residue at 2'- or 3'-OH groups of 3'-terminal ribose residue. No protection of the 5'-hydroxyl group or internal 2'-hydroxyl groups is required for this specific reaction. Anthraniloyl-tRNA which is an analogue of aminoacyl-tRNA forms a ternary complex with EF-Tu*GTP. The anthraniloyl-residue is used as a fluorescent reporter group to monitor interactions with proteins.

  DOI：

  10.1080/07328319808004677

文献信息

• Aminoacyl-tRNA Analogues; Synthesis, Purification and Properties of 3^′-Anthraniloyl Oligoribonucleotides
  作者：B. Nawrot、M. Sprinzl

  DOI：10.1080/07328319808004677

  日期：1998.4

  Reaction of isatoic anhydride with adenosine, adenosine 5'-phosphate, oligoribonucleotides or with the E. coli tRNA(Val) led to attachment of an anthraniloyl residue at 2'- or 3'-OH groups of 3'-terminal ribose residue. No protection of the 5'-hydroxyl group or internal 2'-hydroxyl groups is required for this specific reaction. Anthraniloyl-tRNA which is an analogue of aminoacyl-tRNA forms a ternary complex with EF-Tu*GTP. The anthraniloyl-residue is used as a fluorescent reporter group to monitor interactions with proteins.