二乙烯基二氯化锡 | 7532-85-6

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机锡
• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 二乙烯基二氯化锡
• 英文名称: divinyltin(IV) dichloride
• 英文别名: Divinylzinndichlorid；Divinyl-dichlor-zinn；dichlorodivinylstannane；Divinyldichlorstannan；Dichlor-di-vinyl-stannan；Dichlorodivinyltin；bis(ethenyl)tin(2+);dichloride
• CAS: 7532-85-6
• 化学式: C₄H₆Cl₂Sn
• 分子量: 243.708
• InChiKey: LWHKXKZPLXYXRO-UHFFFAOYSA-L

物化性质

• 沸点：
  54-6°C 3mm
• 密度：
  1.7645
• 闪点：
  54-56°C/3mm
• 暴露限值：
  ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• TSCA：
  No
• 危险等级：
  6.1
• 危险品运输编号：
  UN2788
• 包装等级：
  II
• 危险类别：
  6.1
• 储存条件：
  密封在阴凉干燥的环境中。

SDS

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Section 1: Product Identification
Chemical Name: Divinyltin dichloride, 98%
CAS Registry Number: 7532-85-6
Formula: (CH2=CH)2SnCl2
EINECS Number: 231-399-1
Chemical Family: organotin compound
Synonym: Dichlorodiethenylstannane

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 7532-85-6 100% 0.1mg/m3 0.1mg/m3

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Section 3: Hazards Identification
Emergency Overview: Corrosive to skin, eyes and respiratory tract. Harmful if swallowed,
Primary Routes of Exposure: Ingestion, inhalation, skin, eyes
Eye Contact: Causes severe burns to the eyes and blindness.
Skin Contact: Prolonged contact will cause redness and corrosive acid burns to the skin.
Corrosive to the nose, mucous membranes and respiratory tract. High doses may cause long term
Inhalation:
neurological damage.
Harmful if swallowed. Delayed and permanent psycho-neurologic disturbances; impairment of vision,
Ingestion:
unsteadiness, nausea and vomiting.
Corrosive to skin, eyes and mucous membranes. Ingestion of certain organotin compounds may cause
Acute Health Affects:
delayed poisoning (4 days) with cerebral edema causing damage to the central nervous system.
Repeated exposure to certain organic tin compounds may cause problems with vision, skin, respiratory
Chronic Health Affects:
system, central nervous system, liver, kidneys, urinary tract, and blood.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, foam or dry powder
Fire fighters should be equipped with a NIOSH approved positive pressure self-contained breathing apparatus
Special Fire Fighting Procedures:
and full protective clothing.
Hazardous Combustion and carbon monoxide, carbon dioxide, soot, organic fumes and tin compounds.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Small spills can be neutralized with powdered sodium bicarbonate, lime, or calcium carbonate and swept up.
Spill and Leak Procedures: Large spills in areas not adequately ventilated will require an evacuation of site. Emergency response teams
will require self-contained breathing apparatus.

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SECTION 7: Handling and Storage
Handling and Storage: Store in a cool, dry, well ventilated area away from heat and direct sunlight. Keep containers tightly sealed.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.
Ventilation: Work with this product in a well-ventilated area, preferably a fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Work with this product in a well-ventilated area, preferably a fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: colorless liq.
Molecular Weight: 243.69
Melting Point: no data
Boiling Point: 54-56°C /3 mm
Vapor Pressure: no data
Specific Gravity: no data
Odor: irritating odor
Solubility in Water: insoluble

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SECTION 10: Stability and Reactivity
Stability: moisture sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: strong oxidizing agents and halogens
Decomposition Products: carbon monoxide, carbon dioxide, tin oxide, and organic fumes.

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SECTION 11: Toxicological Information
Administration into the eye (rabbit); Standard Draize Test: 100ul/24H. Oral (rat); LDLo: 500mg/kg. Inhalation
RTECS Data:
(rat); LC: >933mg/m3/1H.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Avoid release to groundwater or waterways. Very toxic to aquatic organisms. May cause long-term adverse
Ecological Information:
effects.

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to federal, state, and local regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Corrosive liquids, N.O.S.
Hazard Class (CFR): 8
Additional Hazard Class (CFR): NA
Packaging Group (CFR): II
UN ID Number (CFR): UN# 1760
Shipping Name (IATA): Corrosive liquid, N.O.S.
Hazard Class (IATA): 8
Additional Hazard Class (IATA): NA
Packaging Group (IATA): II
UN ID Number (IATA): UN# 1760

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SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  dichloroaluminum hydride 、 二乙烯基二氯化锡 以 not given 为溶剂， 生成 bis-vinylstannane
  参考文献：
  名称：

  Vinylstannanes: synthesis and characterization

  摘要：

  Primary, secondary and tertiary vinylstannanes 2a-2f are synthesized by reduction of the corresponding chloro(vinyl)stannanes. They are characterized by their spectral data (IR, NMR (Sn-119, C-13, H-1) spectroscopy and mass spectrometry). The Sn-119 chemical shifts and (1)J(SnH) and (1)J(SnC) of vinylstannanes are compared with the data reported for the corresponding alkyl- and aryl-stannanes. Compounds 2 decompose slowly at room temperature in benzene (tau(1/2) 1-3 days). The formation of divinylchlorostannane and the use of trivinylstannane as a reducing agent are also reported.

  DOI：

  10.1016/0022-328x(94)05057-i
• 作为产物：
  描述：

  四乙烯基锡 、 氯化铊 以 乙醚 为溶剂， 生成 二乙烯基二氯化锡
  参考文献：
  名称：

  Borisov, A. E.; Novikova, N. V., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya

  摘要：

  DOI：

文献信息

• Synthesis and characterisation of tin(IV) and organotin(IV) derivatives 2-{[(2-hydroxyphenyl)imino]methyl}phenol
  作者：Claudio Pettinari、Fabio Marchetti、Riccardo Pettinari、Domenico Martini、Andrei Drozdov、Sergei Troyanov

  DOI：10.1016/s0020-1693(01)00654-5

  日期：2001.12

  From the interaction of 2-[(2-hydroxyphenyl)imino]methyl}phenol(salopH2) with tin and organotin(IV) acceptors, the derivatives [SnR3(salopH)] (R=Me or Bun), [SnR2(salop)] (R=Me, Bun, But, Vin or Ph), [SnRX(salop)(solvent)] (R=Me, Bun, Ph or X; X=Cl, Br or I; solvent=CH3OH or H2O), [Sn(salop)2], [R2SnCl2(salopH2)] (R=Me or Bun) have been obtained and characterised. The chelates, containing the Schiff

  从2-[（（2-羟基苯基）亚氨基]甲基}苯酚（salopH 2）与锡和有机锡（IV）受体的相互作用中，衍生物[SnR 3（salopH）]（R = Me或Bu n），[ SnR 2（salop）]（R = Me，Bu n，Bu t，Vin或Ph），[SnRX（salop）（solvent）]（R = Me，Bu n，Ph或X; X = Cl，Br或I ;溶剂= CH 3 OH或H 2 O），[Sn（salop）2 ]，[R 2 SnCl 2（salopH 2）]（R = Me或Bu n）已获得并表征。包含单或双阴离子形式的席夫碱的螯合物通常在固态和溶液中均稳定，而[SnR 2 Cl 2（salopH 2）]加合物在丙酮或DMSO中缓慢分解，生成[SnR 2（salop） ）]并释放HCl。所有的[SnR 2（salop）]和[SnRX（salop）（溶剂）]配合物在溶液中都是流动的。的119
• (S)-N-[(2-hydroxynaphthalen-1-yl)methylidene]valine – A valuable ligand for the preparation of chiral complexes
  作者：Sandra Schwarzer、Uwe Böhme、Sabine Fels、Betty Günther、Erica Brendler

  DOI：10.1016/j.ica.2018.08.011

  日期：2018.11

  different hypercoordinated complexes depending on the substitution of the starting material. The dianion of 1 therein acts as tridentate ligand in κ3O,N,O’ coordination mode. Complexes with silicon, germanium, tin, and titanium have been prepared in that way and are presented here as proof of concept. With one exception diorganoelement chlorides R2ECl2 yield pentacoordinate complexes LER2. Element tetrachlorides

  摘要（S）-N-[（2-羟基萘-1-基）亚甲基]缬氨酸（H2L），1与第4组和第14组有机卤化物的反应导致不同的超配位络合物，具体取决于原料的取代。其中的二价阴离子在κ3O，N，O'配位模式下充当三齿配体。硅，锗，锡和钛的配合物已通过这种方式制备，并在此处作为概念证明提供。除了一个例外，双有机元素氯化物R2EC12产生五配位络合物LER2。元素四氯化物产生六配位络合物L2E。通过NMR，IR和UV / Vis光谱，元素和X射线结构分析来表征所制备的化合物。此外，固态NMR测量和借助量子化学方法的化学位移张量分析被用于研究几种产物中心原子周围的电子密度分布。这项研究表明1形成具有不同元素的手性超坐标配合物的能力。
• Exploration of organotin(IV) derivatives for medicinal applications: Synthesis, spectroscopic characterization, structural elucidation and molecular docking study
  作者：Muhammad Sirajuddin、Saqib Ali、Vickie McKee、Abdul Wadood、Mehreen Ghufran

  DOI：10.1016/j.molstruc.2018.12.041

  日期：2019.4

  play the role of a bridge between the adjacent tin atoms symmetrically giving a polymeric chain structure. In compound 4, oxygen of the amide carbonyl moiety perform the same function and bridges the adjacent tin atoms [Sn O = 2.155 (3) and 2.428 (3) A, respectively], with the three phenyl ipso-C atoms defining the trigonal plane and the axial positions occupied by O atoms [O1 Sn O3 = 177.62 (11) A]

  摘要 羧酸盐配体 4-(4-甲氧基苯胺基)-4-氧代丁酸的有机锡 (IV) 衍生物已合成并通过 FTIR、NMR、CHN 分析、质谱和 X 射线晶体学表征。四种化合物 (1-4) 的单晶数据显示出围绕 Sn 的扭曲三角双锥环境，其中三个赤道位置被烷基占据。在化合物 1-3 中，配体的羧化氧在相邻锡原子之间起到桥梁的作用，对称地形成聚合物链结构。在化合物 4 中，酰胺羰基部分的氧执行相同的功能并桥接相邻的锡原子 [Sn O = 2.155 (3) 和 2.428 (3) A]，其中三个苯基 ipso-C 原子定义了三角平面和 O 原子占据的轴向位置 [O1 Sn O3 = 177.62 (11) A]。为复合物 1-4 计算的 τ 值分别为 0.78、0.77、0.82 和 0.92，也证实了三角双锥几何。合成化合物的抗菌结果说明了它们作为潜在的抗菌剂的用途。通过紫外-可见光谱和分子对接进行的
• Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations
  作者：Muhammad Sirajuddin、Vickie McKee、Muhammad Tariq、Saqib Ali

  DOI：10.1016/j.ejmech.2017.11.001

  日期：2018.1

  Fourteen new organotin(IV) carboxylate complexes with peptide linkage of (2-(4-methoxy-2-nitrophenylcarbamoyl)benzoic acid) were successfully synthesized and characterized by elemental analyses, FT-IR, NMR (1H, 13C and 119Sn) and single crystal X-ray techniques. FT-IR results of the sodium salt of 2-(4-methoxy-2-nitrophenylcarbamoyl)benzoic acid and complexes showed that the coordination took place

  成功合成了14种具有（2-（4-甲氧基-2-硝基苯基氨基甲酰基）苯甲酸的肽键的有机锡（IV）羧酸酯配合物，并通过元素分析，FT-IR，NMR（1 H，13 C和119 Sn ）和单晶X射线技术。的2-（4-甲氧基-2- nitrophenylcarbamoyl）的钠盐的FT-IR结果苯甲酸和络合物表明，协调发生经由羧酸基团的氧原子。1 J（119 Sn- 13 C），2 J（119 Sn- 1 H）和从1 H和13计算出的θ值使用Lockhart方程的C NMR数据揭示了三有机锡（IV）衍生物的三角双锥体几何形状和双有机锡（IV）衍生物的八面体几何形状。三个三有机锡（IV）配合物（晶体学数据1 - 3）显示锡已经扭曲三角双锥几何形状。还研究了合成化合物对肺癌（H-157）和肾成纤维细胞（BHK-21）细胞系的体外抗癌活性以及对利什曼原虫主要前鞭毛体形式的抗疟疾活性，并且发现该复合物具有生物
• Spectroscopic characterizations, structural peculiarities, molecular docking study and evaluation of biological potential of newly designed organotin(IV) carboxylates
  作者：Muhammad Sirajuddin、Saqib Ali、Vickie McKee、Naheed Akhtar、Saiqa Andleeb、Abdul Wadood

  DOI：10.1016/j.jphotobiol.2019.111516

  日期：2019.8

  The synthesized complexes were characterized by several spectroscopic techniques. A chelating or bridging bidentate nature of the carboxylate ligand was suggested from the solid state FT-IR results. Solution state multinuclear NMR (1H, 13C and 119Sn) results reveal that the geometry around the Sn atom in triorganotin(IV) complexes is trigonal bipyramidal and in diorganotin(IV) complexes is octahedral

  在寻找新的治疗剂中，我们合成了13种新的（E）-4-（（4-甲氧基-2-硝基苯基）氨基）-4-氧代丁-2-烯酸的有机锡（IV）羧酸酯衍生物。合成的配合物通过几种光谱技术表征。从固态FT-IR结果暗示了羧酸盐配体的螯合或桥联二齿性质。溶液状态的多核NMR（1H，13C和119Sn）结果表明，三有机锡（IV）配合物中Sn原子周围的几何形状是三角双锥体，而二有机锡（IV）配合物中则是八面体。还通过单晶X射线技术分析了配体（E）-4-（（4-甲氧基-2-硝基苯基）氨基）-4-氧代丁-2-烯酸，配合物1和配合物2，并将结果完全支持光谱数据。对于1和2，通过单晶X射线分析优化的几何形状是变形的三角双锥体。通过UV-Vis研究了所研究化合物与SS-DNA的相互作用。光谱和分子对接显示结合的插入模式。筛选出的用于癌症治疗的化合物的评估结果甚至高于用作标准药物的长春新碱。类似地，被测化合物作为抗菌剂的性能认