二十六烷醛 | 26627-85-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 二十六烷醛
• 英文名称: hexacosanal aldehyde
• 英文别名: n-hexacosan-1-al；1-hexacosanal；hexacosanal；ceraldehyde；cerotic aldehyde；cerylic aldehyde
• CAS: 26627-85-0
• 化学式: C₂₆H₅₂O
• 分子量: 380.698
• InChiKey: QAXXQMIHMLTJQI-UHFFFAOYSA-N

物化性质

• 沸点：
  395.4±5.0 °C(Predicted)
• 密度：
  0.836±0.06 g/cm3(Predicted)
• LogP：
  12.596 (est)
• 物理描述：
  Solid
• 熔点：
  73-73.5°C
• 保留指数：
  2815

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  27
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2912190090

反应信息

• 作为反应物：
  描述：

  二十六烷醛 在 tris(6,6,7,7,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato)europium(III) 、 camphor-10-sulfonic acid 作用下， 以 环己烷 、 甲苯 为溶剂， 反应 30.0h， 生成 (2R,3R,4S)-methyl 2-((R)-4-ethyl-2-oxooxazolidin-3-yl)-3-tetracosyl-4-tridecyl-3,4-dihydro-2H-pyran-6-carboxylate
  参考文献：
  名称：

  一种用于不对称获取包含两个脂链链的内酯的收敛性 Hetero-Diels-Alder 策略

  摘要：

  Eu(fod)3 催化的手性 β-烷基-N-vinyl-1,3-oxazolidin-2-ones 与带有脂质链的杂二烯的杂环加成反应导致杂环加合物以高产率获得，具有优异的内选择性和表面选择性。原始脂质内酯，神经酰胺类似物的有效前体，在适当的功能化后以会聚方式从加合物中分七个步骤获得。

  DOI：

  10.1002/ejoc.201200513
• 作为产物：
  描述：

  二十六碳醇 在 pyridinium chlorochromate 作用下， 生成 二十六烷醛
  参考文献：
  名称：

  摘要：

  Bioassay-guided fractionations of a dichloromethane extract of wheat epicuticular wax allowed the identification of 1-octacosanal and 6-metboxy-2-benzoxazolinone (MBOA) as the major components that stimulate oviposition by the Hessian fly, Mayetiola destructor. These compounds were identified by their mass spectral fragmentation patterns and by comparison of their gas chromatographic retention times with synthetic samples. Synthetic samples of 1-octacosanal or MBOA stimulated significant oviposition when compared with solvent controls. In combination, these compounds elicited a synergistic effect an the number of eggs laid by females compared to when they were presented alone. In a choice bioassay, a mixture of synthetic 1-octacosanal and MBOA in the approximate concentrations determined to be present in one plant equivalent of crude extract stimulated the same amount of oviposition as one plant equivalent of extract. This showed that together these two compounds appear to be responsible for the major proportion of the ovipositional stimulatory activity of the wheat epicuticular wax extract. Comparison of the activity of five straight-chain primary aldehydes with chain lengths from C-22 to C-30 revealed a relationship between chain length and the number of eggs laid by female Hessian flies, with 1-hexacosanal and 1-heptacosanal the most active of the aldehydes tested.

  DOI：

  10.1023/a:1005499907009

文献信息

• [EN] GLYCOPEPTIDE VACCINE<br/>[FR] VACCIN GLYCOPEPTIDIQUE
  申请人：VICTORIA LINK LTD

  公开号：WO2020231274A1

  公开（公告）日：2020-11-19

  The present invention generally relates to a glycopeptide conjugate compound of Formula (I):, as described herein, compositions comprising the conjugate compound and to the use of such a compound to as a vaccine.

  本发明总体上涉及如本文所述的公式(I)的糖肽偶联化合物，包含该偶联化合物的组合物，以及将这种化合物用作疫苗的使用。
• MULTI-VALENT ADJUVANT DISPLAY
  申请人：Psioxus Therapeutics Limited

  公开号：US20170112923A1

  公开（公告）日：2017-04-27

  The present invention provides an adjuvant-polymer construct comprising a polymer backbone which is covalently linked to 3 or more adjuvants, wherein the 3 or more adjuvants are each present in a pendant side chain, the adjuvants being connected to the polymer backbone either directly or via a spacer group.

  本发明提供了一种佐剂-聚合物构造体，包括一个聚合物骨架，该聚合物骨架与3个或更多佐剂共价连接，其中这3个或更多佐剂分别存在于一个挂链侧链中，佐剂与聚合物骨架之间通过直接连接或通过间隔基团连接。
• Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same
  申请人：Ohta Keisuke

  公开号：US20090209475A1

  公开（公告）日：2009-08-20

  Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R 1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.

  Sulfoquinovosylacyl丙二醇化合物的化学式（I）表示如下：其中R1是脂肪酸的酰基残基，Y为1、2或3的数字，M代表具有与Y相等的正电荷的阳离子及其药用盐，对治疗肿瘤有效。
• Methylene Blue Derivatives
  申请人：Rariy V. Roman

  公开号：US20070116757A1

  公开（公告）日：2007-05-24

  Pharmaceutical compositions comprising a fatty acid salt, a dicarboxylic acid salt, an alkyl sulfate salt, an aryl sulfate salt or an alkyl aryl sulfonate salt of methylene blue or a derivative of methylene blue are described herein. The compositions are preferably administered orally and can be administered as tablets, soft or hard shell capsules (e.g. soft gelatin capsules), suspensions or solutions. The composition can also be formulated as a suppository or enema or rectal administration. The compositions further comprise a pharmaceutically acceptable carrier and optionally one or more pharmaceutically acceptable excipients. Suitable excipients include diluents, binders, plasticizers, lubricants, disintegrants, colorants, stabilizers, surfactants, and combinations thereof. The fatty acid salts, alkyl sulate salts, aryl sulfate salts or alkyl aryl sulfonate salts can be co-mixed or co-melted with one or more fatty acids to make more hydrophobic compositions, which may result in less staining formulations. The compositions can be formulated for immediate release, controlled release such as extended release, delayed release, and pulsatile release, or combinations thereof. In one embodiment, the derivative of methylene blue is methylene dodecylsulfate.

  本文描述了包含脂肪酸盐、二羧酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐的甲蓝或甲蓝衍生物的制药组合物。这些组合物最好是口服给药，可以制成片剂、软壳或硬壳胶囊（例如软明胶胶囊）、悬浮液或溶液进行给药。该组合物也可以制成栓剂或灌肠剂或直肠给药。这些组合物还包括一种药用可接受载体，以及可选地一种或多种药用可接受的辅料。适用的辅料包括稀释剂、粘结剂、增塑剂、润滑剂、崩解剂、色素、稳定剂、表面活性剂以及它们的组合。脂肪酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐可以与一种或多种脂肪酸共混或共熔，制成更疏水的组合物，这可能导致更少的染色配方。这些组合物可以制成即时释放、控制释放（如延长释放）、延迟释放和脉冲释放，或者以上述的组合形式。在一个实施例中，甲蓝的衍生物是十二烷基硫酸甲蓝。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。