4-imidazolone-5-propionic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-imidazolone-5-propionic acid
• 英文别名: 3-(5-Oxoimidazol-4-yl)propanoic acid
• 化学式: C₆H₆N₂O₃
• 分子量: 154.125
• InChiKey: MEHJCGVGSXZMDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  79.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-imidazolone-5-propionic acid 在 IPPAnase 作用下， 生成 formiminoglutamic acid
  参考文献：
  名称：

  Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

  摘要：

  Sunlight exposure is known to affect mood, learning, and cognition. However, the molecular and cellular mechanisms remain elusive. Here, we show that moderate UV exposure elevated blood urocanic acid (UCA), which then crossed the blood-brain barrier. Single-cell mass spectrometry and isotopic labeling revealed a novel intra-neuronal metabolic pathway converting UCA to glutamate (GLU) after UV exposure. This UV-triggered GLU synthesis promoted its packaging into synaptic vesicles and its release at glutamatergic terminals in the motor cortex and hippocampus. Related behaviors, like rotarod learning and object recognition memory, were enhanced after UV exposure. All UV-induced metabolic, electrophysiological, and behavioral effects could be reproduced by the intravenous injection of UCA and diminished by the application of inhibitor or short hairpin RNA (shRNA) against urocanase, an enzyme critical for the conversion of UCA to GLU. These findings reveal a new GLU biosynthetic pathway, which could contribute to some of the sunlight-induced neurobehavioral changes.

  DOI：

  10.1016/j.cell.2018.04.014
• 作为产物：
  描述：

  尿刊酸 在 Urocanase 作用下， 生成 4-imidazolone-5-propionic acid
  参考文献：
  名称：

  Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain

  摘要：

  Sunlight exposure is known to affect mood, learning, and cognition. However, the molecular and cellular mechanisms remain elusive. Here, we show that moderate UV exposure elevated blood urocanic acid (UCA), which then crossed the blood-brain barrier. Single-cell mass spectrometry and isotopic labeling revealed a novel intra-neuronal metabolic pathway converting UCA to glutamate (GLU) after UV exposure. This UV-triggered GLU synthesis promoted its packaging into synaptic vesicles and its release at glutamatergic terminals in the motor cortex and hippocampus. Related behaviors, like rotarod learning and object recognition memory, were enhanced after UV exposure. All UV-induced metabolic, electrophysiological, and behavioral effects could be reproduced by the intravenous injection of UCA and diminished by the application of inhibitor or short hairpin RNA (shRNA) against urocanase, an enzyme critical for the conversion of UCA to GLU. These findings reveal a new GLU biosynthetic pathway, which could contribute to some of the sunlight-induced neurobehavioral changes.

  DOI：

  10.1016/j.cell.2018.04.014

文献信息

• Methods for identifying therapeutic targets for treating infectious disease
  申请人：——

  公开号：US20030130179A1

  公开（公告）日：2003-07-10

  This invention provides methods and systems to identify enzymes that act as enzyme catalyzed therapeutic activators and the enzymes identified by these methods. Also provided by this invention are compounds activated by the enzymes as well as compositions containing these compounds.

  本发明提供了一种识别作为酶催化治疗活化剂的酶的方法和系统，以及通过这些方法识别的酶。本发明还提供了被这些酶激活的化合物以及含有这些化合物的组合物。
• GEL COMPOSITIONS OF OXYMETAZOLINE AND METHODS OF USE
  申请人：Shanler Stuart D.

  公开号：US20130079379A1

  公开（公告）日：2013-03-28

  Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein.

  本文描述了涵盖咪唑啉α激动剂的凝胶实施例，例如，但不限于甲醛唑啉或其药学上可接受的盐，并且描述了用这样的凝胶治疗疾病的方法，例如，但不限于酒渣鼻，包括红斑毛细血管扩张型酒渣鼻、丘疹脓疱型酒渣鼻、皮肤增厚型酒渣鼻、眼部酒渣鼻或其组合；以及与酒渣鼻相关的症状，例如丘疹、脓疱、酒渣鼻（皮肤增厚）、毛细血管扩张或与酒渣鼻相关的红斑或红色症状，其他皮肤红斑、毛细血管扩张、紫斑或类似症状以及与之相关的其他表现或其组合。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Methods of expressing products in mammalian cells
  申请人：Intrexon CEU, INC.

  公开号：US10000770B2

  公开（公告）日：2018-06-19

  The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.

  本发明涉及新发现的可选择标记系统、用于可选择标记系统的细胞以及使用可选择标记系统的方法。
• [DE] VERWENDUNG VON CARNOSIN ODER EINE KOMBINATION MIT UROCANINSÄURE ZUR BEHANDLUNG VON PHOTODERMATOSEN<br/>[EN] USE OF CARNOSINE OR A COMBINATION WITH UROCANIC ACID FOR TREATMENT OF PHOTODERMATOSES<br/>[FR] UTILISATION DE CARNOSINE SEULE OU EN COMBINAISON AVEC L'ACIDE UROCANIQUE POUR LE TRAITEMENT DES PHOTODERMATOSES
  申请人：BEIERSDORF AG

  公开号：WO1994021245A1

  公开（公告）日：1994-09-29

  (DE) Verwendung von Carnosin oder dessen Derivaten oder Analogen oder der Kombination der Wirkstoffe a) Carnosin oder dessen Derivate oder Analoge und b) Urocaninsäure oder deren Derivate oder Analoge oder jeweils Gemischen dieser Verbindungen, gegebenenfalls jeweils in Kombination mit einem Antioxydans oder mehreren Antioxydantien und gegebenenfalls mit einem geeigneten Träger, für kosmetische und dermatologische Zwecke, insbesondere zur Prophylaxe und Behandlung von lichtempfindlicher Haut, insbesondere Photodermatosen und bevorzugt der polymorphen Lichtdermatose.(EN) The invention pertains to the use of carnosine or its derivatives or analogues or the combination of the active substances a) carnosine or its derivatives or analogues and b) urocanic acid or its derivatives or analogues, or in each case mixtures of these compounds, possibly in each case in combination with an antioxidant or several antioxidants and possibly with a suitable carrier, for cosmetic and dermatological purposes, in particular for prophylaxis and treatment of light-sensitive skin, especially photodermatoses and preferably polymorphous photodermatosis.(FR) L'invention concerne l'utilisation de carnosine ou de ses dérivés ou analogues ou bien de la combinaison des principes actifs a) carnosine ou ses dérivés ou analogues et b) acide urocanique ou ses dérivés ou analogues, ou bien dans chaque cas des mélanges de ces composés, éventuellement dans chaque cas en combinaison avec un antioxydant ou plusieurs antioxydants et éventuellement avec un excipient approprié, à des fins cosmétiques et dermatologiques, notamment pour la prophylaxie et le traitement des peaux photosensibles, en particulier des photodermatoses, et de préférence de la photodermatose polymorphe.

  这项发明涉及卡诺斯（Carnosine）及其衍生物、类物或组合物或它们的组合的使用，特别是用于美容和皮肤科目的用途，其中包括光敏感皮肤的预防和治疗，特别是光性皮肤问题和较理想的多态光性皮肤。