(E)-4-(4-methoxyphenyl)-5-(4-methoxystyryl)-2-phenyloxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-4-(4-methoxyphenyl)-5-(4-methoxystyryl)-2-phenyloxazole
• 英文别名: 4-(4-methoxyphenyl)-5-[(E)-2-(4-methoxyphenyl)ethenyl]-2-phenyl-1,3-oxazole
• 化学式: C₂₅H₂₁NO₃
• 分子量: 383.447
• InChiKey: GTUSPEQXSJOZSQ-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,4-bis(4-methoxyphenyl)-1,3-butadiyne 、 苯甲腈 在 cesiumhydroxide monohydrate 作用下， 以 1,4-二氧六环 为溶剂， 以70%的产率得到(E)-4-(4-methoxyphenyl)-5-(4-methoxystyryl)-2-phenyloxazole
  参考文献：
  名称：

  Transition-Metal-Free Heterocyclization of 1,3-Diynes with Nitriles in the Presence of Aqueous Potassium Hydroxide: Synthesis of 2,4-Disubstituted 5-[(E)-2-Phenylethenyl]-1,3-oxazoles

  摘要：

  A transition-metal-free heterocyclization of 1,3-diynes and nitriles in the presence of either aqueous potassium hydroxide or cesium hydroxide in 1,4-dioxane at 100 degrees C was realized. This method provided stereoselectively 2,4-disubstituted 5-[(E)-2-phenylethenyl]-1,3-oxazoles in moderate to good yields.

  DOI：

  10.1055/s-0034-1378316

文献信息

• Transition-Metal-Free Heterocyclization of 1,3-Diynes with Nitriles in the Presence of Aqueous Potassium Hydroxide: Synthesis of 2,4-Disubstituted 5-[(E)-2-Phenylethenyl]-1,3-oxazoles
  作者：Xiaoming Zhao、Ling Ming、Jialiang Tang

  DOI：10.1055/s-0034-1378316

  日期：——

  A transition-metal-free heterocyclization of 1,3-diynes and nitriles in the presence of either aqueous potassium hydroxide or cesium hydroxide in 1,4-dioxane at 100 degrees C was realized. This method provided stereoselectively 2,4-disubstituted 5-[(E)-2-phenylethenyl]-1,3-oxazoles in moderate to good yields.