1,2-O-cyclohexylidene-5-deoxy-5-dodecylamino-α-D-xylofuranose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-O-cyclohexylidene-5-deoxy-5-dodecylamino-α-D-xylofuranose
• 英文别名: (3aR,5R,6S,6aR)-5-[(dodecylamino)methyl]spiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclohexane]-6-ol
• 化学式: C₂₃H₄₃NO₄
• 分子量: 397.599
• InChiKey: QEAFWUXXGRXNTB-CIAFKFPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  十二烷基伯胺 、 3,5-anhydro-1,2-O-cyclohexylidene-α-D-xylofuranose 以 水 为溶剂， 反应 8.0h， 以76.5%的产率得到1,2-O-cyclohexylidene-5-deoxy-5-dodecylamino-α-D-xylofuranose
  参考文献：
  名称：

  Efficient nitrogen alkylation with carbohydrates

  摘要：

  Efficient nitrogen alkylation of various primary and secondary amines, including cyclic, heterocyclic and alkaloid type amines, with a sugar oxetane 3,5-anhydro-1,2-O-cyclohexylidene-alpha-D-xylofuranose is described. As a result, 5-amino-5-deoxy derivatives of xylofuranose were obtained in good yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(03)00114-9

文献信息

• Efficient nitrogen alkylation with carbohydrates
  作者：Pavle Hadžić、Nada Vukojević

  DOI：10.1016/s0008-6215(03)00114-9

  日期：2003.5

  Efficient nitrogen alkylation of various primary and secondary amines, including cyclic, heterocyclic and alkaloid type amines, with a sugar oxetane 3,5-anhydro-1,2-O-cyclohexylidene-alpha-D-xylofuranose is described. As a result, 5-amino-5-deoxy derivatives of xylofuranose were obtained in good yields. (C) 2003 Elsevier Science Ltd. All rights reserved.