二氢-5-壬基-2(3H)-呋喃酮 | 7370-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 中文名称: 二氢-5-壬基-2(3H)-呋喃酮
• 英文名称: 5-nonyldihydrofuran-2(3H)-one
• 英文别名: γ-tridecalactone；gamma-tridecalactone；2(3H)-Furanone, dihydro-5-nonyl-；5-nonyloxolan-2-one
• CAS: 7370-36-7
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: JKAJPOOMLFHWAY-UHFFFAOYSA-N

物化性质

• 熔点：
  22 °C
• 沸点：
  309℃
• 密度：
  0.925
• 闪点：
  126℃
• 保留指数：
  2488

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二氢-5-壬基-2(3H)-呋喃酮 在 potassium hydroxide 作用下， 以100 %的产率得到4-hydroxytridecanoic acid
  参考文献：
  名称：

  2-HYDROXY AND 4-HYDROXY GLYCOLIPIDS AND THEIR DERIVATIVES

  摘要：

  Described are glycolipids having a saccharide moiety attached at the 2-position of the lipid chain (i.e., "2-hydroxy glycolipids"), glycolipids having a saccharide moiety attached at the 4-position of the lipid chain (i.e., "4-hydroxy glycolipids"), and derivatives thereof. Further described are synthetic methods for preparing 2-hydroxy glycolipids, 4-hydroxy glycolipids, and derivatives thereof.

  公开号：

  WO2024137705A1
• 作为产物：
  描述：

  1-furan-2-ylnonan-1-ol 在 盐酸 、 sodium hydroxide 、 sodium tetrahydroborate 作用下， 反应 5.5h， 生成 二氢-5-壬基-2(3H)-呋喃酮
  参考文献：
  名称：

  Sorochinskaya, A. M.; Kovalev, B. G.; Avdeeva, L. A., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 2, p. 277 - 283

  摘要：

  DOI：

文献信息

• CYP505E3: A Novel Self‐Sufficient ω‐7 In‐Chain Hydroxylase
  作者：Mpeyake Jacob Maseme、Alizé Pennec、Jacqueline Marwijk、Diederik Johannes Opperman、Martha Sophia Smit

  DOI：10.1002/anie.202001055

  日期：2020.6.22

  The self‐sufficient cytochrome P450 monooxygenase CYP505E3 from Aspergillus terreus catalyzes the regioselective in‐chain hydroxylation of alkanes, fatty alcohols, and fatty acids at the ω‐7 position. It is the first reported P450 to give regioselective in‐chain ω‐7 hydroxylation of C10–C16 n ‐alkanes, thereby enabling the one step biocatalytic synthesis of rare alcohols such as 5‐dodecanol and 7‐tetradecanol

  来自土曲霉的自给自足的细胞色素P450单加氧酶CYP505E3催化ω-7位烷烃，脂肪醇和脂肪酸的区域选择性链内羟化反应。这是第一个报道的P450，具有C10–C16 n的区域选择性链内ω-7羟基化作用链烷烃，从而一步一步生物催化合成稀有醇（如5-十二烷醇和7-十四烷醇）。它显示出一个甲基末端对第八个碳原子的区域选择性超过70％，并且对癸烷（TTN≈8000）和十二烷（TTN≈2000）的活性很高。CYP505E3可用于通过两种途径合成高价值风味化合物δ-十二内酯：1）将十二烷酸转化为5-羟基十二烷酸（区域选择性为24％），在低pH内酰胺酶下可转化为δ-十二内酯，以及2）转化将1-十二烷醇转化为1,5-十二烷二醇（55％的区域选择性），可以通过马肝醇脱氢酶将其转化为δ-十二烷内酯。
• Blood selenium concentrations and enzyme activities related to glutathione metabolism in wild emperor geese
  作者：J. Christian Franson、David J. Hoffman、Joel A. Schmutz

  DOI：10.1002/etc.5620211022

  日期：2002.10

  relationship to selenium in the blood of wild birds. Adult female emperor geese incubating their eggs in mid-June had a higher mean concentration of selenium in their blood and a greater activity of glutathione peroxidase in their plasma than adult geese or goslings that were sampled during the adult flight feather-molting period in late July and early August. Glutathione peroxidase activity was positively

  1998 年，我们在美国阿拉斯加西部育空-库斯科克维姆三角洲 (YKD) 的繁殖地采集了 63 只帝雁 (Chen canagica) 的血样。我们研究了全血中硒浓度与血浆中谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性之间的关系。实验研究表明，这些酶的血浆活性是硒诱导的氧化应激的有用生物标志物，但关于它们与野生鸟类血液中硒的关系的信息很少。6 月中旬孵化卵的成年雌性帝鹅血液中硒的平均浓度更高，血浆中谷胱甘肽过氧化物酶的活性高于 7 月下旬成年飞羽换羽期间采集的成年鹅或雏鹅和八月初。谷胱甘肽过氧化物酶活性与帝雁血硒浓度呈正相关，幼鹅相对于硒的升高幅度大于成年鹅。谷胱甘肽还原酶的活性在雏鹅血浆中最高，在蜕皮的成年雏鹅中比在孵化的雌雏中更高，但与成年雏鹅或雏鹅血液中的硒没有显着相关性。孵化的雌性帝鹅血液中的硒浓度很高，伴随着与早期氧化应激一致的谷胱甘肽过氧化物酶活性增加。这些发现表明，有必要在该物种中
• Anticancer agents, perfumes or foods and drinks containing omega-hydroxyfatty acids
  申请人：——

  公开号：US20030055105A1

  公开（公告）日：2003-03-20

  The present invention relates to drugs and, particularly, to anticancer agents. More particularly, the present invention relates to an anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of &ohgr;-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures. With respect to the compounds described above used in the present invention, since the activities of killing cancer and inhibiting cancer metastasis are significantly high, the effects of preventing the recurrence of cancer and preventing cancer are exhibited, the cytotoxicity is significantly low, and a small dose is effective, it is possible to provide anticancer agents having significantly decreased side effects. Additionally, use in combination with known antitumor agents can further enhance the activity of inhibiting cancer metastasis. Among the anticancer agents of the present invention, &ohgr;-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing lactones which are also the anticancer agents of the present invention.

  本发明涉及药物，特别是抗癌剂。更具体地说，本发明涉及一种抗癌剂，其含有至少一种从以下化合物组合中选择的活性成分，包括ω-羟基脂肪酸及其盐或酯、羟基酮脂肪酸及其盐或酯、内酯、大环酮和具有特定化学结构的大环二酯。对于本发明中所述的上述化合物，由于其杀灭癌细胞和抑制癌转移的活性显著高，具有预防癌症复发和预防癌症的效果，细胞毒性显著低，且小剂量就能发挥作用，因此能够提供具有显著降低副作用的抗癌剂。此外，与已知的抗肿瘤药物结合使用可以进一步增强抑制癌转移的活性。在本发明的抗癌剂中，ω-羟基脂肪酸可以通过水解也是本发明的抗癌剂的内酯轻松获得高纯度。
• ANTICANCER AGENTS, PERFUMES OR FOODS AND DRINKS CONTAINING $g(v)-HYDROXYFATTY ACIDS
  申请人：SODA AROMATIC COMPANY, LIMITED

  公开号：EP1249236A1

  公开（公告）日：2002-10-16

  The present invention relates to drugs and, particularly, to anticancer agents. More particularly, the present invention relates to an anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of ω-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures. With respect to the compounds described above used in the present invention, since the activities of killing cancer and inhibiting cancer metastasis are significantly high, the effects of preventing the recurrence of cancer and preventing cancer are exhibited, the cytotoxicity is significantly low, and a small dose is effective, it is possible to provide anticancer agents having significantly decreased side effects. Additionally, use in combination with known antitumor agents can further enhance the activity of inhibiting cancer metastasis. Among the anticancer agents of the present invention, ω-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing lactones which are also the anticancer agents of the present invention.

  本发明涉及药物，特别是抗癌剂。 更具体地说，本发明涉及一种抗癌剂，其中含有至少一种选自具有特定化学结构的ω-羟基脂肪酸及其盐或酯、羟基氧代脂肪酸及其盐或酯、内酯、大环酮和大环二酯组成的组的化合物作为活性成分。 对于本发明中使用的上述化合物，由于杀灭癌症和抑制癌症转移的活性显著较高，具有防止癌症复发和预防癌症的效果，细胞毒性显著较低，且小剂量即可有效，因此可以提供副作用显著降低的抗癌剂。此外，与已知的抗肿瘤药物联合使用可进一步提高抑制癌症转移的活性。在本发明的抗癌剂中，ω-羟基脂肪酸很容易通过水解内酯得到高纯度的ω-羟基脂肪酸，这些内酯也是本发明的抗癌剂。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。