N,N-dibutyl-3,4,5-trimethoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dibutyl-3,4,5-trimethoxybenzamide
• 化学式: C₁₈H₂₉NO₄
• 分子量: 323.433
• InChiKey: YGNOFOCCEWYREC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 、 二正丁胺 在 二氧化碳 、 叔丁基过氧化氢 、 iron(II) chloride tetrahydrate 、 四丁基溴化铵 作用下， 以 水 、 乙腈 为溶剂， 反应 16.0h， 以45%的产率得到N,N-dibutyl-3,4,5-trimethoxybenzamide
  参考文献：
  名称：

  In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes

  摘要：

  An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.066

文献信息

• In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes
  作者：Thulasiram Bathini、Vikas S. Rawat、Sreedhar Bojja

  DOI：10.1016/j.tetlet.2015.08.066

  日期：2015.10

  An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol. (C) 2015 Elsevier Ltd. All rights reserved.