4-(2',3',4'-trimethoxyphenyl)butan-4-olide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2',3',4'-trimethoxyphenyl)butan-4-olide
• 英文别名: 5-(2,3,4-Trimethoxyphenyl)oxolan-2-one；5-(2,3,4-trimethoxyphenyl)oxolan-2-one
• 化学式: C₁₃H₁₆O₅
• 分子量: 252.267
• InChiKey: FQTKJORAPPFDBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,2,3-三甲氧基苯 在 palladium on activated charcoal 、 In(OSO₂CF₃)3 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 100.0~110.0 ℃ 、344.74 kPa 条件下， 反应 25.0h， 生成 4-(2',3',4'-trimethoxyphenyl)butan-4-olide
  参考文献：
  名称：

  Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides

  摘要：

  A catalytic, green and practical method for Friedel-Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)(3) or Bronsted acid, such as H2SO4 in acetic acid provides gamma-aryl gamma-butenolides in moderate to excellent yield. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.02.009

文献信息

• Cameron, Donald W.; Feutrill, Geoffrey I.; Pietersz, Geoffrey A., Australian Journal of Chemistry, 1982, vol. 35, # 7, p. 1481 - 1488
  作者：Cameron, Donald W.、Feutrill, Geoffrey I.、Pietersz, Geoffrey A.

  DOI：——

  日期：——
• Lewis and Brönsted acid catalyzed Friedel–Crafts hydroxyalkylation of mucohalic acids: a facile synthesis of functionalized γ-aryl γ-butenolides
  作者：Ji Zhang、Peter G. Blazecka、Timothy T. Curran

  DOI：10.1016/j.tetlet.2007.02.009

  日期：2007.4

  A catalytic, green and practical method for Friedel-Crafts hydroxyalkylation of mucohalic acid has been accomplished. Reaction of mucohalic acids with various electron-rich aromatic compounds in the presence of catalytic (1 mol % to 10 mol %) In(OTf)(3) or Bronsted acid, such as H2SO4 in acetic acid provides gamma-aryl gamma-butenolides in moderate to excellent yield. (c) 2007 Elsevier Ltd. All rights reserved.