(S)-3-Carboxyethyl-γ-butyrolacton | 63095-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (S)-3-Carboxyethyl-γ-butyrolacton
• 英文别名: 3-[(3R)-5-oxooxolan-3-yl]propanoic acid
• CAS: 63095-50-1
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: MRERCGZKGNQDJT-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR PREPARING OPTICALLY PURE (R)-4-N-PROPYL-DIHYDROFURAN-2(3H)-ONE
  申请人：Beijing AblePharmtech Co., Ltd.

  公开号：EP3543229A1

  公开（公告）日：2019-09-25

  The present invention discloses a process for preparing optically pure (R)-4-n-propyl-dihydrofuran -2(3H)-one, belonging to the field of chemical synthesis. According to the process, optically pure (S)-3-n-pentanoyl-4-substituted oxazol-2-one is used as a starting material, and after alkylation, reduction, cyano hydrolysis, lactonization, the product optically pure (R)-4-n-propyl-dihydrofuran -2(3H)-one is given. The preparation process has the advantages of easy availability of raw materials, low price, high yield, high optical purity of product, simple reaction conditions and simple operations.

  本发明公开了一种制备光学纯(R)-4-正丙基二氢呋喃-2(3H)-酮的工艺，属于化学合成领域。根据该工艺，以光学纯的(S)-3-正戊酰基-4-取代的噁唑-2-酮为起始原料，经烷基化、还原、氰水解、内酯化后，得到光学纯的(R)-4-正丙基二氢呋喃-2(3H)-酮。该制备工艺具有原料易得、价格低廉、收率高、产品光学纯度高、反应条件简单、操作简便等优点。
• Process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one
  申请人：BEIJING ABLEPHARMTECH CO., LTD.

  公开号：US10975050B2

  公开（公告）日：2021-04-13

  The present invention discloses a process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one, belonging to the field of chemical synthesis. According to the process, optically pure (S)-3-n-pentanoyl-4-substituted oxazol-2-one is used as a starting material, and after alkylation, reduction, cyano hydrolysis, lactonization, the product optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one is given. The preparation process has the advantages of easy availability of raw materials, low price, high yield, high optical purity of product, simple reaction conditions and simple operations.

  本发明公开了一种制备光学纯(R)-4-正丙基二氢呋喃-2(3H)-酮的工艺，属于化学合成领域。根据该工艺，以光学纯的(S)-3-正戊酰基-4-取代的噁唑-2-酮为起始原料，经烷基化、还原、氰水解、内酯化后，得到光学纯的(R)-4-正丙基二氢呋喃-2(3H)-酮。该制备工艺具有原料易得、价格低廉、收率高、产品光学纯度高、反应条件简单、操作简便等优点。