5-(1-methyl-1H-indol-3-ylmethylene)-pyrimidine-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(1-methyl-1H-indol-3-ylmethylene)-pyrimidine-2,4,6-trione
• 英文别名: 5-[(1-Methylindol-3-yl)methylidene]-1,3-diazinane-2,4,6-trione
• 化学式: C₁₄H₁₁N₃O₃
• 分子量: 269.26
• InChiKey: LIWOPDBINUULRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  80.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-吲哚甲醛 在 L-酪氨酸 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 0.43h， 生成 5-(1-methyl-1H-indol-3-ylmethylene)-pyrimidine-2,4,6-trione
  参考文献：
  名称：

  Facile Synthesis and Biological Evaluation of Substituted 5-(1H-Indol-3-ylmethylene) pyrimidine-2,4,6-trione Derivatives Using L-Tyrosine in Aqueous Medium

  摘要：

  L-酪氨酸作为一种高效催化剂，促进取代的吲哚-3-醛1(a-d)、N-甲基吲哚-3-醛4(a-d)、N-乙基吲哚-3-醛6(a-d)与含有环状活性亚甲基基团的巴比妥酸（2）在室温下水相中反应10分钟，生成3(a-d)、5(a-d)和7(a-d)。已研究了3(a-d)、5(a-d)和7(a-d)的抗菌活性。

  DOI：

  10.14233/ajchem.2013.15364

文献信息

• Novel, Recyclable, and Thermally Stable Task-Specific Ionic Liquid (TBA Acetate) Medium/Catalyst for the Synthesis of Indolylidinecyclic-1,3- and -1,4-diketones
  作者：Sd. Riyaz、A. Indrasena、A. Naidu、P. Dubey

  DOI：10.1080/00397911.2013.806988

  日期：2014.2

  A simple and efficient synthesis of indolylidinethiazolidnediones (3) and indolylidinecyclic-1,3-diketones (5) has been developed by reaction of indole-3-aldehyde (1) with thiazolidinedione (2) or cyclic-1,3-diketones (4) using tetra butyl ammonium acetate (TBAA) melt as novel, cost-effective, and recyclable ionic liquid under solvent-free green conditions at 100 degrees C for 15-20min without additional use of catalyst. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
• Pigment dispersion liquid, curable composition, color filter, produced using the same, and solid state imaging device
  申请人：FUJIFILM Corporation

  公开号：EP2036957B1

  公开（公告）日：2012-01-11
• PIGMENT DISPERSION LIQUID, CURABLE COMPOSITION, COLOR FILTER PRODUCED USING THE SAME, AND SOLID STATE IMAGING DEVICE
  申请人：SHIMADA Kazuto

  公开号：US20090017273A1

  公开（公告）日：2009-01-15

  The present invention provides a pigment dispersion liquid including a pigment, a compound having a cyclic urea structure and having an acid group or a basic group, a dispersant, and a solvent. The pigment may be a pigment having a urea structure or an imide structure. The pigment may also be a pigment having a barbituric skeleton.
• COMBINATION THERAPIES FOR OVERCOMING RESISTANCE TO MITOTIC AGENTS DURING CHEMOTHERAPY
  申请人：EMORY UNIVERSITY

  公开号：US20160095859A1

  公开（公告）日：2016-04-07

  This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic inhibitor such as a taxane and a vinca alkaloid in combination with a compound that inhibits CHFR and PARP1 interactions, such as 5-((1-benzyl-1H-indol-3-yl)methylene)-1-(3,4-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione, derivatives or salts thereof, optionally in further combination with a third anti-cancer agent.
• US8008364B2
  申请人：——

  公开号：US8008364B2

  公开（公告）日：2011-08-30