2,4-dichloro-1-(hexyloxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dichloro-1-(hexyloxy)benzene
• 英文别名: 2,4-Dichloro-1-hexoxybenzene；2,4-dichloro-1-hexoxybenzene
• 化学式: C₁₂H₁₆Cl₂O
• 分子量: 247.164
• InChiKey: OFLWGPZWWXSDCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  溴己烷 、 2,4-二氯酚 在 copper(ll) sulfate pentahydrate 、 caesium carbonate 、 sodium ascorbate 作用下， 以 二甲基亚砜 为溶剂， 反应 12.0h， 以76%的产率得到2,4-dichloro-1-(hexyloxy)benzene
  参考文献：
  名称：

  Copper and l -sodium ascorbate catalyzed hydroxylation and aryloxylation of aryl halides

  摘要：

  CuSO4 center dot 5H(2)O and NaAsc catalyzed hydroxylation and C-O/C-S cross-coupling reactions of aryl halides with phenols or 4-methylbenzenethiol were described. A wide range of substrates and test cases highlight the synthetic utility of the approach. A series of phenols, diaryl ethers, allcylaryl ethers, and diaryl thioethers were synthesized in high yield. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.08.066

文献信息

• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACÉTYLCHOLINESTÉRASE
  申请人：UNIV COLUMBIA

  公开号：WO2014113495A1

  公开（公告）日：2014-07-24

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• Copper and l -sodium ascorbate catalyzed hydroxylation and aryloxylation of aryl halides
  作者：Guang-Lin Song、Zhang Zhang、Yu-Xia Da、Xi-Cun Wang

  DOI：10.1016/j.tet.2015.08.066

  日期：2015.11

  CuSO4 center dot 5H(2)O and NaAsc catalyzed hydroxylation and C-O/C-S cross-coupling reactions of aryl halides with phenols or 4-methylbenzenethiol were described. A wide range of substrates and test cases highlight the synthetic utility of the approach. A series of phenols, diaryl ethers, allcylaryl ethers, and diaryl thioethers were synthesized in high yield. (C) 2015 Elsevier Ltd. All rights reserved.