5-methylthio-3H-thiophen-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢噻吩类
• 英文名称: 5-methylthio-3H-thiophen-2-one
• 英文别名: 5-methylsulfanyl-3H-thiophen-2-one
• 化学式: C₅H₆OS₂
• 分子量: 146.234
• InChiKey: FPFNODKWQXXAMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二甲基二硫 、 2-diethylcarbamoyloxythiophene 在 四甲基乙二胺 、 仲丁基锂 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 2.0h， 以31%的产率得到5-methylthio-3H-thiophen-2-one
  参考文献：
  名称：

  o-Directed Lithiation of Acylated Hydroxythiophenes

  摘要：

  O-Carbamates derived from 2-hydroxy- and 3-hydroxy-thiophenes generated o-directed carbanions, which were transformed to the corresponding methyl sulfides and methyl and trimethylsilyl substituted thiophenes.Dedicated to Professor Viktoras Snieckus, an eminent organic chemist and initiator of Balticum Organicum Syntheticum (BOS), in occasion of his 77th birthday

  DOI：

  10.3987/com-13-s(s)91

文献信息

• o-Directed Lithiation of Acylated Hydroxythiophenes
  作者：Peteris Trapencieris、Ineta Vendina、Anete Parkova

  DOI：10.3987/com-13-s(s)91

  日期：——

  O-Carbamates derived from 2-hydroxy- and 3-hydroxy-thiophenes generated o-directed carbanions, which were transformed to the corresponding methyl sulfides and methyl and trimethylsilyl substituted thiophenes.Dedicated to Professor Viktoras Snieckus, an eminent organic chemist and initiator of Balticum Organicum Syntheticum (BOS), in occasion of his 77th birthday