2-Fluoroheptane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 2-Fluoroheptane
• 英文别名: 2-Fluor-heptan
• 化学式: C₇H₁₅F
• 分子量: 118.195
• InChiKey: PMRPAQPKUQJWLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-庚醇 在 N,N-二甲基四氟乙胺 作用下， 以 四氯化碳 为溶剂， 生成 1-庚烯 、 2-庚烯 、 2-Fluoroheptane
  参考文献：
  名称：

  1,1,2,2-四氟乙基-N，N-二甲基胺：一种新型的选择性氟化剂

  摘要：

  通过四氟乙烯和二甲胺的反应，可以制备标题化合物，产率为96–98％。发现1,1,2,2-四氟乙基-N，N-二甲基胺（1）是将醇转化为烷基氟化物的有效试剂。1和伯醇的反应在高温下以高收率形成了相应的烷基氟化物。但是，仲醇和叔醇的反应在0–10°C下迅速发生，产生相应的烷基氟化物作为主要产物以及一些烯烃。

  DOI：

  10.1016/s0022-1139(01)00372-4

文献信息

• [EN] BETA-LACTAMASE INHIBITORS<br/>[FR] INHIBITEURS DE BÊTA-LACTAMASES
  申请人：VENATORX PHARMACEUTICALS INC

  公开号：WO2017100537A1

  公开（公告）日：2017-06-15

  Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

  本文描述了调节β-内酰胺酶活性的化合物和组合物。在某些实施例中，所述化合物抑制β-内酰胺酶。在特定实施例中，所述化合物在治疗细菌感染方面是有用的。
• POTASSIUM FLUORIDE DISPERSION SOLUTION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME
  申请人：Hagiya Koji

  公开号：US20090099387A1

  公开（公告）日：2009-04-16

  A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.

  一种氟化钾分散体，基本上由氟化钾和沸点高于甲醇的无极性有机溶剂组成，可通过将含有氟化钾和每1份氟化钾重量配比5至50份甲醇的混合物与无极性有机溶剂混合后浓缩所得混合物而获得，以及一种制备含氟有机化合物的方法，包括将至少具有一个能够被氟原子亲核取代的基团的有机化合物与氟化钾分散体接触。
• ALKALI METAL FLUORIDE DISPERSION AND PROCESS FOR PRODUCING FLUORINE-CONTAINING ORGANIC COMPOUND USING THE SAME
  申请人：Hagiya Koji

  公开号：US20110112321A1

  公开（公告）日：2011-05-12

  An alkali metal fluoride dispersion essentially consisting of an alkali metal fluoride and an aprotic organic solvent obtainable by conducting the following Step (A), subsequently conducting the following Step (B) at least once, and then conducting the following Step(C); Step (A): a step of separating a liquid phase from an alkali metal fluoride dispersion comprising at least one alcohol solvent selected from the group consisting of methanol, ethanol and isopropanol and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85° C. or higher at normal pressure to obtain a mixture containing the alkali metal fluoride; Step (B): a step of obtaining a mixture containing the alkali metal fluoride comprising the following Steps (b1) to (b3); Step (b1): a step of concentrating the mixture containing the alkali metal fluoride obtained in Step (A) or Step (b3) to obtain a concentrated fraction and a concentrated residue; Step (b2): a step of mixing a residue of the alkali metal fluoride dispersion obtained by separating the liquid phase in Step (A) or a residue of the mixture obtained by separating a liquid phase in Step (b3) with the concentrated fraction obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (b3): a step of separating a liquid phase from the mixture containing an alkali metal fluoride obtained in Step (b2) and mixing the separated liquid phase with the concentrated residue obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (C): a step of removing the alcohol solvent from the mixture containing the alkali metal fluoride, which is obtained in Step (B), to obtain the alkali metal fluoride dispersion essentially consisting of the alkali metal fluoride and the aprotic organic solvent.

  一种碱金属氟化物分散体，基本上由碱金属氟化物和无水有机溶剂组成，可通过进行以下步骤（A），随后至少进行以下步骤（B）一次，然后进行以下步骤（C）获得；步骤（A）：将包括甲醇、乙醇和异丙醇中至少一种醇溶剂和碱金属氟化物的碱金属氟化物分散体中的液相与沸点在常压下为85°C或更高的无水有机溶剂混合，以获得含有碱金属氟化物的混合物；步骤（B）：获取含有碱金属氟化物的混合物，包括以下步骤（b1）至（b3）；步骤（b1）：浓缩在步骤（A）或步骤（b3）中获得的含有碱金属氟化物的混合物，以获得浓缩分数和浓缩残渣；步骤（b2）：将通过在步骤（A）中分离液相获得的碱金属氟化物分散体残渣或通过在步骤（b3）中分离液相获得的混合物残渣与在步骤（b1）中获得的浓缩分数混合，以获得含有碱金属氟化物的混合物；步骤（b3）：从在步骤（b2）中获得的含有碱金属氟化物的混合物中分离液相，并将分离的液相与在步骤（b1）中获得的浓缩残渣混合，以获得含有碱金属氟化物的混合物；步骤（C）：从在步骤（B）中获得的含有碱金属氟化物的混合物中去除醇溶剂，以获得基本上由碱金属氟化物和无水有机溶剂组成的碱金属氟化物分散体。
• Potassium Fluoride
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2471741A1

  公开（公告）日：2012-07-04

  The invention relates to a potassium fluoride which a part or all of the initial particles, of which particle diameter is 0.1 to 5 µm, are flocculated to form particles having 5 to 25 µm of volumetric average particle diameter. The potassium fluoride is useful in producing a fluorine-containing organic compound from an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom.

  本发明涉及一种氟化钾，其部分或全部初始颗粒（颗粒直径为 0.1 至 5 微米）经絮凝后形成体积平均颗粒直径为 5 至 25 微米的颗粒。该氟化钾可用于从至少有一个基团可被氟原子亲核取代的有机化合物中生产含氟有机化合物。
• LIQUID CRYSTAL COMPOUND HAVING DIFLUOROMETHYLENEOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3275971A1

  公开（公告）日：2018-01-31

  Provided are a liquid crystal compound satisfying at least one of physical properties such as high stability to heat and light, a high clearing point (or high maximum temperature), low minimum temperature of the liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, large dielectric constant in a minor axis direction, a suitable elastic constant and excellent compatibility with other liquid crystal compounds; a liquid crystal composition containing the liquid crystal compound; and a liquid crystal display device including the composition. The compound is represented by formula (1). In formula (1), for example R1 is alkyl having 1 to 12 carbons; ring A1 is 1, 4-cyclohexylene; ring B1 is 1,4-phenylene; Z1, Z2 and Z3 are a single bond; L1, L2, L3, L4, L5, L6, L7, L8 and L9 are hydrogen or halogen; X1 is fluorine; a is 1 to 3; and n1 and n2 are independently 0 or 1.

  本发明提供了一种液晶化合物，该化合物至少满足以下物理特性之一：对热和光的稳定性高、清澈点（或最高温度高）高、液晶相的最低温度低、粘度小、适当的光学各向异性、介电各向异性大、小轴方向上的介电常数大、适当的弹性常数以及与其他液晶化合物的兼容性好；一种含有该液晶化合物的液晶组合物；以及一种包括该组合物的液晶显示设备。 该化合物用式（1）表示。 在式 (1) 中，例如 R1 是具有 1 至 12 个碳原子的烷基；环 A1 是 1，4-环己烯；环 B1 是 1，4-亚苯基；Z1、Z2 和 Z3 是单键；L1、L2、L3、L4、L5、L6、L7、L8 和 L9 是氢或卤素；X1 是氟；a 是 1 至 3；n1 和 n2 独立地为 0 或 1。