(2'SR,3SR)-2'-(2,2-dimethylpropyl)-1-methyl-1'-(1-methylethyl)spiro[indole-3,3'-pyrrolidin]-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (2'SR,3SR)-2'-(2,2-dimethylpropyl)-1-methyl-1'-(1-methylethyl)spiro[indole-3,3'-pyrrolidin]-2-one
• 英文别名: (2'S,3S)-2'-(2,2-dimethylpropyl)-1-methyl-1'-propan-2-ylspiro[indole-3,3'-pyrrolidine]-2-one
• 化学式: C₂₀H₃₀N₂O
• 分子量: 314.471
• InChiKey: XGWMQPHSUZASGZ-PXNSSMCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-二甲基丁醛 、 异丙胺 、 1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one 在 magnesium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 生成 (2'SR,3SR)-2'-(2,2-dimethylpropyl)-1-methyl-1'-(1-methylethyl)spiro[indole-3,3'-pyrrolidin]-2-one 、 (2'RS,3SR)-2'-(2,2-dimethylpropyl)-1-methyl-1'-(1-methylethyl)spiro[indole-3,3'-pyrrolidin]-2-one
  参考文献：
  名称：

  A Rapid Three-Component MgI₂-Mediated Synthesis of 3,3-Pyrollidinyl Spirooxindoles

  摘要：

  The rapid synthesis of 3,3-pyrrolidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.

  DOI：

  10.1021/jo101077g

文献信息

• A Rapid Three-Component MgI₂-Mediated Synthesis of 3,3-Pyrollidinyl Spirooxindoles
  作者：Victoria Helan、Allie Mills、David Drewry、Daniel Grant

  DOI：10.1021/jo101077g

  日期：2010.10.1

  The rapid synthesis of 3,3-pyrrolidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.