5-(4-fluorophenyl)-3-methylindolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(4-fluorophenyl)-3-methylindolin-2-one
• 英文别名: 5-(4-Fluorophenyl)-3-methyl-1,3-dihydroindol-2-one；5-(4-fluorophenyl)-3-methyl-1,3-dihydroindol-2-one
• 化学式: C₁₅H₁₂FNO
• 分子量: 241.265
• InChiKey: VYGDRXZQJAYEPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[2-Amino-5-(4-fluorophenyl)phenyl]ethanone 在 四乙基溴化铵 、 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 2.0h， 生成 5-(4-fluorophenyl)-3-methylindolin-2-one
  参考文献：
  名称：

  Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions

  摘要：

  Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.09.123

文献信息

• Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions
  作者：Vikas S. Patil、Shyam S. Pal、Ramdas S. Pathare、L.K.K. Reddy、Arunendra Pathak

  DOI：10.1016/j.tetlet.2015.09.123

  日期：2015.11

  Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives. (C) 2015 Elsevier Ltd. All rights reserved.