2,3-pyridinediol hydrogen chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,3-pyridinediol hydrogen chloride
• 英文别名: 2,3-Dihydroxypyridine hydrochloride；3-hydroxy-1H-pyridin-2-one;hydrochloride
• 化学式: C₅H₅NO₂*Cl*H
• 分子量: 147.561
• InChiKey: CDAOQIOOIJQGFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.39
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二乙基亚磷酰氯 、 2,3-pyridinediol hydrogen chloride 在 四甲基乙二胺 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以91.7%的产率得到(6-Diethoxyphosphanyloxypyridin-2-yl) diethyl phosphite
  参考文献：
  名称：

  Synthesis and characterization of iron complexes based on bis-phosphinite PONOP and bis-phosphite PONOP pincer ligands

  摘要：

  A series of bis-phosphinite and bis-phosphite PONOP iron complexes were prepared and characterized by NMR and IR spectroscopy. Bis-phosphinite PONOP iron dichloride complexes (RPONOP)FeCl2 ((PONOP)-P-R = 2,6-(R2PO)(2)(C5H3N) and R = Tr, tBu) were prepared through complexation of the free ligands with FeCl2 and their solid-state structures were determined. Bis-phosphite PONOP iron complexes (c1E1PONOP)Fe(PMe3)2 and (ca1PONOP)Fe(PMe3)2 (Cat = catechol) were synthesized through complexation of the free ligands to Fe(PMe3)(4). Carbonyl complexes of both bis-phosphinite and bis-phosphite PONOP were prepared and characterized by IR. The monocarbonyl ((PONOPFe)-P-OEt(CO)(2) was accessed through exposure of (111`PONOP)FeCl2 to an atmosphere of CO and the CO stretching frequency was observed at 1969 cm -1. Dicarbonyl complexes ((PONOP)-P-iPr)Fe(C0)2 and ((PONOPFe)-P-OEt(CO)(2) were accessed through reduction of the corresponding chloride complexes with sodium amalgam under a CO atmosphere. Carbonyl stretching frequencies for (RIPONOP)Fe(C0)2 and ( E1PONOPFe)(C0)2 were observed at 1824 and 1876 cm -1, and at 1871 and 1927 cm(-1) respectively. The bis-phosphite PONOP complexes exhibit a less electron rich metal center than the bis-phosphinite PONOP complexes, as would be expected based on the stronger pi-acceptor character of these ligands. The electronic properties of the bisphosphinite PONOP and bis-phosphite PONOP iron complexes are intermediate between previously reported PNP and PDI iron complexes, with the PONOP ligands exhibiting stronger electron donating ability than PDI ligands, but promoting a less electron rich metal center than found in analogous PNP iron complexes. (c) 2014 Elsevier BY. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2014.08.029

文献信息

• DERMATOLOGICAL COMPOSITIONS AND METHODS
  申请人：——

  公开号：US20020141952A1

  公开（公告）日：2002-10-03

  Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

  公开了用于调节哺乳动物黑素细胞的黑色素含量的方法及组合物；通过施用包括醇、二醇和/或三醇及其类似物在内的各种化合物，来调节哺乳动物皮肤、毛发、羊毛或毛皮的色素沉着；以及治疗或预防各种皮肤和增殖性障碍。
• EP0957903A4
  申请人：——

  公开号：EP0957903A4

  公开（公告）日：2002-10-09
• PHARMACEUTICAL COMPOSITIONS AND METHODS
  申请人：Codon Pharmaceuticals, Inc.

  公开号：EP0957903A1

  公开（公告）日：1999-11-24
• Dermatological compositions and methods
  申请人：Applied Genetics Incorporated Dermatics

  公开号：US20040067209A1

  公开（公告）日：2004-04-08

  Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
• US5990177A
  申请人：——

  公开号：US5990177A

  公开（公告）日：1999-11-23