N1-[2-(5-chloro-pyridin-2-yloxy)-1-methylethyl]-L-valinamide hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N1-[2-(5-chloro-pyridin-2-yloxy)-1-methylethyl]-L-valinamide hydrochloride
• 英文别名: N1-[2-(5-chloro-2-pyridyloxy)-1-methylethyl]-L-valinamide hydrochloride；(2S)-2-amino-N-[1-(5-chloropyridin-2-yl)oxypropan-2-yl]-3-methylbutanamide;hydrochloride
• 化学式: C₁₃H₂₀ClN₃O₂*ClH
• 分子量: 322.235
• InChiKey: MJCJIQCAXDOPTM-RLOOEAFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.02
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  77.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N1-[2-(5-chloro-pyridin-2-yloxy)-1-methylethyl]-L-valinamide hydrochloride 、 氯甲酸异丙酯 在 N-甲基吗啉 作用下， 以 二氯甲烷 为溶剂， 以38%的产率得到N1-[2-(5-chloro-pyridin-2-yloxy)-1-methylethyl]-N2-isopropyloxycarbonyl-L-valinamide
  参考文献：
  名称：

  Amino-acid amide derivatives, method for producing the same, and

  摘要：

  本发明提供了一种氨基酸酰胺衍生物，其表示为以下公式：##STR1##（其中R.sup.1代表较低的烷基（可选地具有至少一个相同或不同的卤素原子取代基），R.sup.2代表乙基基团，R.sup.3代表氢原子，R.sup.4代表氢原子，R.sup.5，R.sup.6和R.sup.7分别独立地代表氢原子或较低的烷基，R.sup.8代表氢原子，Z.sup.1和Z.sup.2独立地代表氧原子或硫原子，Z.sup.3代表氧原子或硫原子，Q代表苯基，m表示0到2的整数，n表示0或1），以及包括有效量的农业或园艺杀菌剂。氨基酸酰胺衍生物表现出优良的植物病害控制能力，特别是对霜霉病和晚疫病，且不对植物有害。

  公开号：

  US05811424A1

文献信息

• Amino-acid amide derivatives, agricultural or horticultural fungicides,
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：US05574064A1

  公开（公告）日：1996-11-12

  The present invention provides an agricultural or horticultural fungicide including an effective amount of an amino-acid derivative represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group (optionally having at least one same or different substituent of a halogen atom, an alkoxy group, and a cyano group), R.sup.2 represents an ethyl group, or an n-propyl group, R.sup.3 represents a hydrogen atom or a lower alkyl group, R.sup.4 represents a hydrogen atom, R.sup.5, R.sup.6, and R.sup.7 independently represent a hydrogen atom or a lower alkyl group, R.sup.8 represents a hydrogen atom, or a lower alkyl group, Z.sup.1 and Z.sup.2 independently represent an oxygen atom or a sulfur atom, Z.sup.3 represents an oxygen atom, or a sulfur atom, Q represents a phenyl group, m represents an integer from 0 to 2, and n represents 0 or 1. The amino-acid amide derivatives according to the present invention exhibit superior control of cucumber downy mildew (Pseudoperonospora cubensis), tomato late blight (Phytophthora infestans), and grape downy mildew (Plasmopara viticola), and are effective for potato late blight (Phytophthora infestans). In addition, the agricultural or horticultural fungicides of the present invention are also characterized in that they are not harmful chemicals and exhibit excellent characteristics such as systemic action, residual activity, and persistence after rain-fall.

  本发明提供了一种农业或园艺杀菌剂，包括一种由以下式表示的氨基酸衍生物的有效量：##STR1##其中R.sup.1代表较低的烷基基团（可选地至少具有一个相同或不同的卤原子、烷氧基和氰基取代基），R.sup.2代表乙基基团或正丙基基团，R.sup.3代表氢原子或较低的烷基基团，R.sup.4代表氢原子，R.sup.5、R.sup.6和R.sup.7独立地代表氢原子或较低的烷基基团，R.sup.8代表氢原子或较低的烷基基团，Z.sup.1和Z.sup.2独立地代表氧原子或硫原子，Z.sup.3代表氧原子或硫原子，Q代表苯基，m代表从0到2的整数，n代表0或1。根据本发明的氨基酸酰胺衍生物表现出对黄瓜霜霉病（Pseudoperonospora cubensis）、番茄晚疫病（Phytophthora infestans）和葡萄霜霉病（Plasmopara viticola）的优越控制，并且对马铃薯晚疫病（Phytophthora infestans）有效。此外，本发明的农业或园艺杀菌剂还具有不含有害化学物质的特点，并表现出系统作用、残留活性和雨后持久性等优异特性。
• AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0648740B1

  公开（公告）日：1997-10-08
• Amino-acid amide derivatives, method for producing the same, and
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：US05811424A1

  公开（公告）日：1998-09-22

  The present invention provides an amino-acid amide derivative represented by the formula: ##STR1## (wherein R.sup.1 represents a lower alkyl group (optionally having at least one same or different substituent of a halogen atom), R.sup.2 represents an ethyl group, R.sup.3 represents a hydrogen atom, R.sup.4 represents a hydrogen atom, R.sup.5, R.sup.6, and R.sup.7 independently represent a hydrogen atom or a lower alkyl group, R.sup.8 represents a hydrogen atom, Z.sup.1 and Z.sup.2 independently represent an oxygen atom or a sulfur atom, Z.sup.3 represents an oxygen atom or a sulfur atom, Q represents a phenyl group, m represents an integer from 0 to 2, and n represents 0 or 1), and an agricultural or horticultural fungicide including an effective amount of the same. The amino-acid amide derivatives exhibit a superior control of plant diseases, particularly downy mildew and late blight, and are not harmful to plants.

  本发明提供了一种氨基酸酰胺衍生物，其表示为以下公式：##STR1##（其中R.sup.1代表较低的烷基（可选地具有至少一个相同或不同的卤素原子取代基），R.sup.2代表乙基基团，R.sup.3代表氢原子，R.sup.4代表氢原子，R.sup.5，R.sup.6和R.sup.7分别独立地代表氢原子或较低的烷基，R.sup.8代表氢原子，Z.sup.1和Z.sup.2独立地代表氧原子或硫原子，Z.sup.3代表氧原子或硫原子，Q代表苯基，m表示0到2的整数，n表示0或1），以及包括有效量的农业或园艺杀菌剂。氨基酸酰胺衍生物表现出优良的植物病害控制能力，特别是对霜霉病和晚疫病，且不对植物有害。