C-4'-pyridyl-N-phenylnitrone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: C-4'-pyridyl-N-phenylnitrone
• 英文别名: α-(Z)-4-pyridyl-N-phenylnitrone；(Z)-N-(pyridin-4-ylmethylene)aniline oxide；(Z)-N-phenyl-1-(pyridin-4-yl)methanimine oxide；N-phenyl-1-pyridin-4-ylmethanimine oxide
• 化学式: C₁₂H₁₀N₂O
• 分子量: 198.224
• InChiKey: LJAZWXXSTFVHRG-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C-4'-pyridyl-N-phenylnitrone 在 联硼酸新戊二醇酯 作用下， 以67 %的产率得到(E)-N-phenyl-1-(pyridin-4-yl)methanimine
  参考文献：
  名称：

  硝酮脱氧中的二硼试剂

  摘要：

  B 2 nep 2通过简单、高效、可持续、官能团耐受和可扩展的方案，有效促进硝酮的 N-O 裂解，以非常高的产率形成亚胺。该反应在没有添加剂的情况下通过协同机制发生。我们证明了通常用作自由基陷阱的 DMPO 和 TEMPO 也被二硼试剂脱氧，这证明了它们作为机械探针的局限性。

  DOI：

  10.1039/d2ob01880b
• 作为产物：
  描述：

  4-吡啶甲醛 、 硝基苯 在 溶剂黄146 、 锌 作用下， 以 乙醇 为溶剂， 生成 C-4'-pyridyl-N-phenylnitrone
  参考文献：
  名称：

  I多吡啶配合物敏化α-吡啶基-N-芳基亚硝基配体的光活化异构化反应

  摘要：

  摘要合成了一系列以光异构体为配体的of（I）吡啶基化合物，并通过多种技术对其进行了表征。研究了化合物的光化学和光物理行为。辐射后，硝酮的乙腈溶液或它们各自的络合物在吸收，发射和FTIR光谱中显示出变化。FTIR揭示了相应的苯胺化物的形成是未配位硝酮的辐射光产物，而配合物的辐射由于配位配体的光敏异构化而导致Z→E，这也由HPLC-MS和1H NMR证实。光异构化的量子产率取决于氮取代基的性质，它会改变3ILZ-NitX激发态的能量，通过光敏作用填充。3MLCT成为电子产品中最低的激发态，并导致发射强度增加。Z或E配位的硝酮的光谱性质的变化可用于分子装置，例如光传感器。

  DOI：

  10.1016/j.ica.2020.120009

文献信息

• MODIFIED POLYMER, RUBBER COMPOSITION AND PNEUMATIC TIRE
  申请人：THE YOKOHAMA RUBBER CO., LTD.

  公开号：US20160340446A1

  公开（公告）日：2016-11-24

  The purpose of the present invention is to provide a modified polymer that significantly reduces heat build-up due to the modification when the modified polymer is formed into a rubber composition, a rubber composition containing the modified polymer, and a pneumatic tire in which the rubber composition is used. The modified polymer of the present invention is a modified polymer obtained by modifying a styrene-conjugated diene copolymer (A) with a nitrone compound (B). In the modified polymer, the content of styrene units in the styrene-conjugated diene copolymer (A) is 10% by mass or greater, and the proportion of vinyl bonds among all the double bonds contained in the styrene-conjugated diene copolymer (A) is 5 mol % or greater.

  本发明的目的是提供一种改性聚合物，当改性聚合物形成橡胶组合物时，显著减少热积聚，以及包含改性聚合物的橡胶组合物和使用橡胶组合物的气动轮胎。本发明的改性聚合物是通过用亚硝基化合物（B）改性苯乙烯-共轭二烯共聚物（A）而获得的改性聚合物。在改性聚合物中，苯乙烯-共轭二烯共聚物（A）中苯乙烯单元的含量为质量的10％或更高，并且在苯乙烯-共轭二烯共聚物（A）中所有双键中的乙烯键的比例为5摩尔％或更高。
• α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus
  作者：A.C. Matias、G. Biazolla、G. Cerchiaro、A.F. Keppler

  DOI：10.1016/j.bmc.2015.12.007

  日期：2016.1

  Nitrone-containing compounds are commonly employed as spin traps of free radical species in chemical and biological studies. Some molecules as alpha-phenyl-N-t-butyl nitrone (PBN) and its derivatives have been tested as potential drugs to treat oxidative stress related diseases, as Alzheimer and stroke for example. In this work we report the design and the synthesis of alpha-aryl-N-aryl nitrones and their cytoprotection profile on human neuroblastoma cells (SH-SY5Y) under induced oxidative stress. All the nine synthesized nitrones showed a significant response at low micromolar concentration. The selected compound 8 (alpha-phenyl-N-phenyl nitrone) increased the reduced glutathione (GSH) levels by 65% and lowered the necrotic cell death from 25.8% to 3.8%. Based on our data, the designed highly conjugated nitrone double-bond skeleton can be considered as a good scaffold for further studies regarding oxidative stress-related diseases. (c) 2015 Elsevier Ltd. All rights reserved.
• Synthesis of Neutral Spin-Delocalized Electron Acceptors for Multifunctional Materials
  作者：Brynn M. Dooley、Steven E. Bowles、Tim Storr、Natia L. Frank

  DOI：10.1021/ol701725r

  日期：2007.11.1

  A new synthetic route to stable spin-delocalized radicals, annelated nitronyl nitroxides, has been developed on the basis of the condensation of benzofuroxan with aryl nitrones. The electronic structure of the resulting radicals was investigated through absorption spectroscopy, EPR, electrochemistry, and computation (DFT-UB3LYP). The annelated radicals exhibit electronic transitions in the near IR (850-900 nm) and are excellent electron acceptors (E-red similar to 0.0 vs SCE) ideal for the development of multifunctional magnetic materials.
• RUBBER COMPOSITION, MODIFIED POLYMER, AND TIRE
  申请人：The Yokohama Rubber Co., LTD

  公开号：US20170002101A1

  公开（公告）日：2017-01-05

  An object of the present invention is to provide a modified polymer that can realize a rubber composition having excellent low heat build-up and that has excellent productivity, a rubber composition containing the modified polymer, and a tire produced using the rubber composition. The modified polymer of the present invention is obtained by reacting a modifier having a nitrone group and a carboxy group with a conjugated diene polymer not containing a tetrasubstituted olefin and/or a trisubstituted olefin.
• US6183934B1
  申请人：——

  公开号：US6183934B1

  公开（公告）日：2001-02-06