五乙二醇单苯醚 | 13681-23-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 五乙二醇单苯醚
• 英文名称: 14-phenoxy-3,6,9,12-tetraoxa-tetradecan-1-ol
• 英文别名: Pentaethylene glycol monophenyl ether；2-[2-[2-[2-(2-phenoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
• CAS: 13681-23-7
• 化学式: C₁₆H₂₆O₆
• 分子量: 314.379
• InChiKey: GQNZRWAZGLSXRS-UHFFFAOYSA-N

物化性质

• 沸点：
  430.9±40.0 °C(Predicted)
• 密度：
  1.103±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  环氧乙烷 、 苯酚 在 sodium phenoxide 作用下， 生成 五乙二醇单苯醚
  参考文献：
  名称：

  Miller et al., Journal of the Chemical Society, 1950, p. 3623,3628

  摘要：

  DOI：

文献信息

• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF
  申请人：SEGETIS, INC.

  公开号：US20140147395A1

  公开（公告）日：2014-05-29

  This disclosure is directed to compound of formula (1): wherein R 1 is a C 7-18 alkyl, R 2 is hydrogen or a C 1-3 alkyl, each R 3 , R 4 , R 5 , R 6 , and R 7 is independently hydrogen or a C 1-6 alkyl, a is 2-3, and b is 0-1, its method of preparation and uses thereof in water-borne coating compositions, cleaning compositions, fragrance, and personal care compositions.

  这项披露涉及到化合物的结构式(1)：其中R1是C7-18烷基，R2是氢或C1-3烷基，每个R3、R4、R5、R6和R7独立地是氢或C1-6烷基，a为2-3，b为0-1，以及其在水性涂料组合物、清洁组合物、香料和个人护理组合物中的制备方法和用途。
• Osmium oxide deposited on hydrophilic polymer support
  申请人：——

  公开号：US20040092779A1

  公开（公告）日：2004-05-13

  A carrier for carrying an osmium oxide comprising an aromatic polyolefin having a group shown by the general formula [1]: —A′—O(—A—O) n —R   [1] (wherein, A is an alkylene group; A′ is a direct link or an alkylene group; R is an aryl group; and n is an integer of 1 to 10), an osmium oxide carried by the carrier for carrying an osmium oxide and a method for producing the osmium oxide carried by said carrier, are disclosed. Since the osmium oxide carried by the carrier of the present invention has a group having hydrophilic property, on an oxidation reaction and an asymmetric oxidation reaction, particularly in a heterogeneous solvent system, the osmium oxide carried by the carrier of the present invention enables to produce a diol compound easily and in a high optical yield. And the osmium oxide carried by the carrier of the present invention can be used safely and effectively even for an oxidation reaction etc. with using a compound which has been difficult to react in a nonaqueous solvent.

  本发明公开了一种携带锇氧化物的载体，该载体包括具有通式[1]所示基团的芳香族聚烯烃：—A′—O(—A—O)n—R [1]（其中，A是烷基；A′是直链或烷基；R是芳基；n是1至10的整数），以及携带锇氧化物的载体上的锇氧化物和制备所述载体上携带的锇氧化物的方法。由于本发明所述载体上携带的锇氧化物具有亲水性基团，在氧化反应和不对称氧化反应中，特别是在异相溶剂体系中，本发明所述载体上携带的锇氧化物能够轻松地并且高光学产率地产生二元醇化合物。并且本发明所述载体上携带的锇氧化物即使用于使用在非水溶剂中难以反应的化合物的氧化反应等，也能够安全有效地使用。
• OSMIUM OXIDE DEPOSITED ON HYDROPHILIC POLYMER SUPPORT
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP1366814A1

  公开（公告）日：2003-12-03

  A carrier for carrying an osmium oxide comprising an aromatic polyolefin having a group shown by the general formula [1]:         - A'-O(-A-O)n-R     [1] (wherein, A is an alkylene group; A' is a direct link or an alkylene group; R is an aryl group; and n is an integer of 1 to 10), an osmium oxide carried by the carrier for carrying an osmium oxide and a method for producing the osmium oxide carried by said carrier, are disclosed. Since the osmium oxide carried by the carrier of the present invention has a group having hydrophilic property, on an oxidation reaction and an asymmetric oxidation reaction, particularly in a heterogeneous solvent system, the osmium oxide carried by the carrier of the present invention enables to produce a diol compound easily and in a high optical yield. And the osmium oxide carried by the carrier of the present invention can be used safely and effectively even for an oxidation reaction etc. with using a compound which has been difficult to react in a nonaqueous solvent.

  一种用于承载氧化锇的载体，由具有通式[1]所示基团的芳香族聚烯烃组成： - A'-O(-A-O)n-R [1] (其中，A 是亚烷基；A'是直链或亚烷基；R 是芳基；n 是 1 至 10 的整数）、该载体携带的氧化锇以及生产所述载体携带的氧化锇的方法。由于本发明载体所携带的氧化锇具有亲水性基团，因此在氧化反应和不对称氧化反应中，特别是在异相溶剂体系中，本发明载体所携带的氧化锇能够容易地生成二元醇化合物，且光学产率高。本发明载体所携带的氧化锇甚至可以安全有效地用于氧化反应等，使用在非水溶剂中难以反应的化合物。
• Flushing solutions for coatings removal
  申请人：Henkel KGaA

  公开号：EP1375606A2

  公开（公告）日：2004-01-02

  A flushing solution containing: a) a solvent component, b) an alkaline source; and c) a corrosion inhibitor component is provided. The solvent component preferably contains an alkoxylated aromatic alcohol. The corrosion inhibitor component may contain a fatty acid salt, a mixture of an aliphatic phosphate ester and a buffering agent such as boric acid or phosphoric acid, a mixture of a fatty acid salt, aliphatic phosphate ester, and buffering agent, or a mixture of a fatty acid salt and buffering agent. Alkanolamines are preferably used to form the fatty acid salt and/or as the alkaline source. The flushing solutions can be prepared in stable concentrated form and are useful for removing coatings such as paint from substrate surfaces.

  冲洗溶液包含：a) 溶剂成分；b) 碱性源；c) 缓蚀剂成分。溶剂成分最好含有烷氧基化芳香醇。缓蚀剂成分可包含脂肪酸盐、脂肪族磷酸酯和缓冲剂（如硼酸或磷酸）的混合物、脂肪酸盐、脂肪族磷酸酯和缓冲剂的混合物或脂肪酸盐和缓冲剂的混合物。烷醇胺最好用来形成脂肪酸盐和/或作为碱性源。冲洗溶液可以以稳定的浓缩形式制备，适用于去除基材表面的涂料（如油漆）。