3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-8-(1-methoxy-1-methylethyl)-4H-furo[2,3-h]-1-benzopyran-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-8-(1-methoxy-1-methylethyl)-4H-furo[2,3-h]-1-benzopyran-4-one
• 英文别名: koreanoside C
• 化学式: C₂₇H₂₈O₁₁
• 分子量: 528.513
• InChiKey: SRRLVMQLRYFMFJ-DBRNBHGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.71
• 重原子数：
  38.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  172.19
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-8-(1-methoxy-1-methylethyl)-4H-furo[2,3-h]-1-benzopyran-4-one 在 盐酸 作用下， 以 水 为溶剂， 反应 8.0h， 生成 L-rhamnopyranose
  参考文献：
  名称：

  Flavonoids Isolated from Heat-ProcessedEpimedium koreanumand Their Anti-HIV-1 Activities

  摘要：

  AbstractSystematic phytochemical investigation on heat‐processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl‐flavonol glycosides, koreanosides A–E (1–5, resp.). Their structures were elucidated on the basis of detailed analysis of the 1D‐ and 2D‐NMR spectroscopic data and chemical reactions. Apigenin (11) exhibited moderate anti‐HIV‐1 activity with an EC50 value of 12.8±3.27 μg/ml.

  DOI：

  10.1002/hlca.201500123