N,N-dipropyl-β-alanine amide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-dipropyl-β-alanine amide
• 英文别名: N,N-Dipropyl-β-alanin-amid；β-alanine di n-propylamine amide；3-(Dipropylamino)propanamide
• 化学式: C₉H₂₀N₂O
• mdl: MFCD04346728
• 分子量: 172.271
• InChiKey: LDOSLIPLVBNSPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二正丙胺 、 丙烯酰胺 在 ES-SO₃H*Pyridine 作用下， 以 四氢呋喃 为溶剂， 反应 0.58h， 以94%的产率得到N,N-dipropyl-β-alanine amide
  参考文献：
  名称：

  An efficient biomaterial supported bifunctional organocatalyst (ES-SO3− C5H5NH+) for the synthesis of β-amino carbonyls

  摘要：

  一种由化学改性的含磺酸基团的膨胀玉米淀粉与吡啶反应合成的生物材料负载型有机催化剂，在胺与缺电子烯烃的aza-Michael加成反应中，表现出优异的催化活性，可高效合成β-氨基羰基化合物。与淀粉接枝磺酸酸或相应的均相吡啶盐-对甲苯磺酸盐相比，所制备的双功能有机催化剂显著提高了反应速率。

  DOI：

  10.1039/c0ob00965b

文献信息

• An efficient biomaterial supported bifunctional organocatalyst (ES-SO3− C5H5NH+) for the synthesis of β-amino carbonyls
  作者：Sanny Verma、Suman L. Jain、Bir Sain

  DOI：10.1039/c0ob00965b

  日期：——

  A biomaterial supported organocatalyst, readily synthesized by the reaction of chemically modified sulfonic group containing expanded corn starch with pyridine exhibited excellent catalytic activity for the synthesis of β-amino carbonyls in excellent yields via aza-Michael addition of amines to electron deficient alkenes. A remarkable enhancement in the reaction rates was observed with the prepared bifunctional organocatalyst in comparison to the either starch grafted sulfonic acid or the corresponding homogeneous pyridinium p-toluenesulfonate.

  一种由化学改性的含磺酸基团的膨胀玉米淀粉与吡啶反应合成的生物材料负载型有机催化剂，在胺与缺电子烯烃的aza-Michael加成反应中，表现出优异的催化活性，可高效合成β-氨基羰基化合物。与淀粉接枝磺酸酸或相应的均相吡啶盐-对甲苯磺酸盐相比，所制备的双功能有机催化剂显著提高了反应速率。
• [EN] SUBSTITUTED UREAS AND CARBAMATES<br/>[FR] UREES ET CARBAMATES SUBSTITUES
  申请人：ELAN PHARMACEUTICAL INC

  公开号：WO2004050609A1

  公开（公告）日：2004-06-17

  The invention provides compounds of formula I: useful in treating Alzheimer’s disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  该发明提供了公式I的化合物：用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶酶的抑制剂，可用于治疗阿尔茨海默病和其他以哺乳动物体内A beta肽沉积为特征的疾病。该发明的化合物可用于制备药物组合物和治疗方法，以减少A beta肽的形成。
• NOVEL SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Lopez Roman

  公开号：US20130023521A1

  公开（公告）日：2013-01-24

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及新型选择性泛素特异性蛋白酶抑制剂的发现，它们的制备过程及其治疗用途。
• Hair cosmetic composition
  申请人：KAO CORPORATION

  公开号：EP1754516A2

  公开（公告）日：2007-02-21

  Provided is a hair cosmetic composition containing Components (A) to (C), and having a pH (at 25°C) of from 1 to 5.5 when diluted to 20 times its weight with water: (A) a cationic surfactant, or a tertiary amine represented by the formula (1): (wherein, at least one of R1 to R3 represents a C8-23 aliphatic hydrocarbon and the remainder represents H, C1-6 alkyl or hydroxyalkyl, or benzyl, R4 represents a C1-6 alkylene, A represents -CONH- or -NHCO-, and a stands for 0 or 1), (B) a C8-30 aliphatic alcohol, and (C) toluenesulfonic acid or salt thereof. The hair cosmetic composition is excellent in the effect of restoring the flyaway or waved hair, which has appeared as a result of accumulation of damage due to hair coloring or the like, to its former state before damage and can give the hair good flexibility and smoothness during use of it.

  本发明提供了一种头发化妆品组合物，该组合物含有成分(A)至(C)，当用水稀释至其重量的20倍时，pH值(25℃)为1至5.5： (A) 阳离子表面活性剂，或由式（1）代表的叔胺： (其中，R1 至 R3 中至少有一个代表 C8-23 脂肪族烃，其余代表 H、C1-6 烷基或羟基烷基或苄基，R4 代表 C1-6 亚烷基，A 代表 -CONH- 或 -NHCO-，a 代表 0 或 1)、 (B) C8-30 脂肪醇，和 (C) 甲苯磺酸或其盐。 本发明的头发化妆品组合物具有极佳的效果，可将因染发或类似原因造成的损伤累积而出现的飞扬或波浪状头发恢复到损伤前的状态，并能在使用过程中赋予头发良好的柔韧性和顺滑度。
• The Preparation and Stabilities of Some β-Dialkylaminopropionamides
  作者：John G. Erickson

  DOI：10.1021/ja01144a509

  日期：1952.12