[3-(4-methoxybenzenesulfonylmethyl)benzofuran-2-yl]phenylmethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [3-(4-methoxybenzenesulfonylmethyl)benzofuran-2-yl]phenylmethanone
• 英文别名: (3-{[(4-Methoxyphenyl)sulfonyl]methyl}-1-benzofuran-2-yl)(phenyl)methanone；[3-[(4-methoxyphenyl)sulfonylmethyl]-1-benzofuran-2-yl]-phenylmethanone
• 化学式: C₂₃H₁₈O₅S
• 分子量: 406.459
• InChiKey: INUKOENDCBBJJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  82
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2-hydroxyphenyl)-2-(4-methoxybenzenesulfonyl)ethanone 、 2-羟基苯乙酮 在 bismuth(lll) trifluoromethanesulfonate 作用下， 以 硝基甲烷 为溶剂， 反应 12.17h， 以82%的产率得到[3-(4-methoxybenzenesulfonylmethyl)benzofuran-2-yl]phenylmethanone
  参考文献：
  名称：

  Bi(OTf) ₃ ‐Mediated (4+1) Annulation of α‐Sulfonyl o ‐Hydroxyacetophenones with α‐Hydroxy Arylketones to Access Sulfonyl 2‐Aroylbenzofurans

  摘要：

  AbstractIn this paper, a high‐yield, facile route for the scalable synthesis of sulfonyl 2‐aroylbenzofurans via a Bi(OTf)3‐mediated intermolecular double cyclocondensation of α‐sulfonyl o‐hydroxyacetophenones with substituted α‐hydroxy arylketones under mild open‐vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate‐promoted reactions and conditions are investigated for the efficient one‐pot (4+1) annulation reaction.magnified image

  DOI：

  10.1002/adsc.202100143

文献信息

• Bi(OTf) ₃ ‐Mediated (4+1) Annulation of α‐Sulfonyl <i>o</i> ‐Hydroxyacetophenones with α‐Hydroxy Arylketones to Access Sulfonyl 2‐Aroylbenzofurans
  作者：Meng‐Yang Chang、Kuan‐Ting Chen

  DOI：10.1002/adsc.202100143

  日期：2021.5.18

  AbstractIn this paper, a high‐yield, facile route for the scalable synthesis of sulfonyl 2‐aroylbenzofurans via a Bi(OTf)3‐mediated intermolecular double cyclocondensation of α‐sulfonyl o‐hydroxyacetophenones with substituted α‐hydroxy arylketones under mild open‐vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate‐promoted reactions and conditions are investigated for the efficient one‐pot (4+1) annulation reaction.magnified image