6,7-dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 6,7-dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
• 英文别名: 6,7-Dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
• 化学式: C₁₅H₉Cl₂FN₂O
• 分子量: 323.154
• InChiKey: YOCIHJPOOBRLRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.92
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  6,7-dichloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 在 ammonium hydroxide 、 tetraphosphorus decasulfide 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲醇 、 二乙二醇二甲醚 为溶剂， 生成 6,7-dichloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-amine
  参考文献：
  名称：

  [EN] BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM
  [FR] DÉRIVÉS DE BENZODIAZÉPINE UTILISÉS COMME GABA A GAMMA1 PAM

  摘要：

  The invention provides novel heterocyclic compounds having the general formula (I), andpharmaceutically acceptable salts thereof, wherein R1 to R5 and X are as described herein. (I)Further provided are pharmaceutical compositions including the compounds, processes of5manufacturing the compounds and methods of using the compounds as medicaments, inparticular methods of using the compounds for the treatment or prevention of acuteneurological disorders, chronic neurological disorders and/or cognitive disorders.***

  公开号：

  WO2023046817A1

文献信息

• NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3901155A1

  公开（公告）日：2021-10-27

  The invention provides novel compounds having the general formula (I) wherein R1, R3, R4, R5 and X are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有通式（I）的新化合物，其中R1、R3、R4、R5和X如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• [EN] BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM<br/>[FR] DÉRIVÉS DE BENZODIAZÉPINE EN TANT QUE PAM GABA A GAMMA1
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021213952A1

  公开（公告）日：2021-10-28

  The invention provides novel compounds having the general formula (I) wherein R1, R3, R4, R5 and X are as described herein, compositions including the compounds and methods of using the compounds.
• [EN] NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZODIAZÉPINE COMME AGENTS PAM DE GABA A GAMMA1
  申请人：[en]F. HOFFMANN-LA ROCHE AG

  公开号：WO2023052312A1

  公开（公告）日：2023-04-06

  The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein the variables are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.